Host gene expression shutoff by virus

Viruses are in competition with the host for the cellular translation machinery, prompting some viruses to inhibit host cell gene expression. Preventing the expression of host proteins is also a strategy to counteract the antiviral response .

Some viruses encode proteins which prevent host gene expression by blocking host transcription, suppressing mRNAs or translation.

Viral molecular biology Virion
Virus entry
Transcription and replication
Host-virus interactions
Virus exit
Host cell shutoff Transcription shutoff
» Inhibition of transcription initiation
» Inhibition of RNA polymerase II

mRNA suppression
» Inhibition of pre-mRNA processing
» Inhibition of mRNA nuclear export
» Virus-mediated mRNA decay

Translation shutoff

Links Uniprot Keyword: KW-1190
GO ontology:

Matching UniProtKB/Swiss-Prot entries

414 entries grouped by protein

All proteins are shown (view only 215 complete proteome entries)

Early E1A 32 kDa protein

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E1A_ADE02Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain
E1A_ADE05Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)

pdb 2KJE  2R7G 

Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

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ICP22_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP22_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP22_VZVDVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Transcriptional regulator IE63 (Immediate-early protein 63) (IE63)

ICP22_VZVOVaricella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

Transcriptional transactivator IE63 (Immediate-early protein 63) (IE63)

Transcriptional regulator ICP27 (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)

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ICP27_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP27_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP27_HHV1EHuman herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

Transcriptional regulator ICP27 (Immediate-early protein IE63) (Infected cell protein 27) (ICP27)

Non-structural protein 1 (NS1) (NS1A)

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NS1_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
NS1_I34A1Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

pdb 2GX9  2ZKO  3L4Q  3O9Q  3O9R  3O9S  3O9T  3O9U  3RVC 

NS1_I68A0Influenza A virus (strain A/Aichi/2/1968 H3N2)
NS1_I77A0Influenza A virus (strain A/Alaska/6/1977 H3N2)
NS1_I76A0Influenza A virus (strain A/Anas acuta/Primorje/695/1976 H2N3)
NS1_I60A0Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
NS1_I89A1Influenza A virus (strain A/Beijing/352/1989 H3N2)
NS1_I75A0Influenza A virus (strain A/Beijing/39/1975 H3N2)
NS1_I77AAInfluenza A virus (strain A/Brazil/11/1978 H1N1)
NS1_I18A0Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus ...
NS1_I77AGInfluenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
NS1_I02A0Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
NS1_I49A0Influenza A virus (strain A/Chicken/Germany/n/1949 H10N7)
NS1_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
NS1_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
NS1_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
NS1_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
NS1_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
NS1_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
NS1_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
NS1_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
NS1_I83A5Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
NS1_I83A6Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
NS1_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
NS1_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
NS1_I85A3Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
NS1_I83A1Influenza A virus (strain A/Chile/1/1983 H1N1)
NS1_I96A3Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
NS1_I76A2Influenza A virus (strain A/Duck/Alberta/60/1976 H12N5)

pdb 3D6R  3OA9 

NS1_I56A1Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
NS1_I56A2Influenza A virus (strain A/Duck/England/1/1956 H11N6)
NS1_I49A1Influenza A virus (strain A/Duck/Germany/1949 H10N7)
NS1_I80A6Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
NS1_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
NS1_I69A0Influenza A virus (strain A/England/878/1969 H3N2)
NS1_I91A0Influenza A virus (strain A/Equine/Alaska/1/1991 H3N8)
NS1_I89A7Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8)
NS1_I73A4Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
NS1_I77A9Influenza A virus (strain A/Equine/New Market/1/1977 H7N7)
NS1_I56A3Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
NS1_I86A3Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
NS1_I47A0Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
NS1_I50A0Influenza A virus (strain A/Fort Warren/1/1950 H1N1)
NS1_I34A0Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
NS1_I79A7Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
NS1_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
NS1_I78AFInfluenza A virus (strain A/Gull/Maryland/1824/1978 H13N6)
NS1_I77AFInfluenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
NS1_I80ACInfluenza A virus (strain A/Gull/Massachusetts/26/1980 H13N6)
NS1_I80ADInfluenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
NS1_I36A0Influenza A virus (strain A/Henry/1936 H1N1)
NS1_I88A4Influenza A virus (strain A/Herring gull/DE/677/1988 H2N8)
NS1_I40A0Influenza A virus (strain A/Hickox/1940 H1N1)
NS1_I68A4Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
NS1_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
NS1_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
NS1_I83A8Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
NS1_I80AAInfluenza A virus (strain A/India/6263/1980 H1N1)
NS1_I57A0Influenza A virus (strain A/Japan/305/1957 H2N2)
NS1_I68A5Influenza A virus (strain A/Korea/426/1968 H2N2)
NS1_I54A0Influenza A virus (strain A/Leningrad/1/1954 H1N1)
NS1_I57A2Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
NS1_I57A1Influenza A virus (strain A/Leningrad/134/1957 H2N2)
NS1_I57A3Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
NS1_I54A2Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
NS1_I78A1Influenza A virus (strain A/Mallard/Alberta/827/1978 H8N4)
NS1_I76A5Influenza A virus (strain A/Mallard/Alberta/88/1976 H3N8)
NS1_I78A3Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
NS1_I78A4Influenza A virus (strain A/Mallard/New York/6874/1978 H3N2)
NS1_I87A1Influenza A virus (strain A/Mallard/Ohio/556/1987 H5N9)
NS1_I71A1Influenza A virus (strain A/Memphis/1/1971 H3N2)
NS1_I72A4Influenza A virus (strain A/Memphis/101/1972 H3N2)
NS1_I72A3Influenza A virus (strain A/Memphis/102/1972 H3N2)
NS1_I76A6Influenza A virus (strain A/Memphis/110/1976 H3N2)
NS1_I78A8Influenza A virus (strain A/Memphis/18/1978 H3N2)
NS1_I78A7Influenza A virus (strain A/Memphis/2/1978 H3N2)
NS1_I80A4Influenza A virus (strain A/Memphis/4/1980 H3N2)
NS1_I00A1Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
NS1_I79A1Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)
NS1_I79A2Influenza A virus (strain A/Pintail/Alberta/121/1979 H7N8)
NS1_I78AAInfluenza A virus (strain A/Pintail/Alberta/268/1978 H6N2)
NS1_I79A3Influenza A virus (strain A/Pintail/Alberta/358/1979 H3N6)
NS1_I73A5Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
NS1_I70A0Influenza A virus (strain A/Qu/7/1970 H3N2)
NS1_I85A7Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
NS1_I06A0Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
NS1_I80A2Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
NS1_I82A3Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)
NS1_I72A5Influenza A virus (strain A/Shearwater/Australia/1972 H6N5)
NS1_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
NS1_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
NS1_I57A5Influenza A virus (strain A/Singapore/1/1957 H2N2)
NS1_I77A4Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
NS1_I30A0Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
NS1_I61A1Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
NS1_I72A6Influenza A virus (strain A/Tern/Turkmenia/18/1972 H3N3)
NS1_I67A0Influenza A virus (strain A/Tokyo/3/1967 H2N2)
NS1_I82A8Influenza A virus (strain A/Turkey/Bethlehem-Glilit/1492-B/1982 H1N1)
NS1_I63A1Influenza A virus (strain A/Turkey/Canada/1963 H6N8)
NS1_I83A4Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
NS1_I78ACInfluenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
NS1_I80A8Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
NS1_I68A3Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
NS1_I66A0Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
NS1_I71A2Influenza A virus (strain A/Turkey/Oregon/1971 H7N3)
NS1_I66A1Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
NS1_I72A2Influenza A virus (strain A/Udorn/307/1972 H3N2)

pdb 1AIL  1NS1  2KKZ  2RHK  3EE8  3EE9  3KWG  3KWI 

NS1_I51A0Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
NS1_I45A0Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
NS1_I43A0Influenza A virus (strain A/USA:Iowa/1943 H1N1)
NS1_I96A2Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
NS1_I35A3Influenza A virus (strain A/USA:Phila/1935 H1N1)
NS1_I07A0Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
NS1_I77ABInfluenza A virus (strain A/USSR/90/1977 H1N1)
NS1_I000WInfluenza A virus (strain A/Wa-182)
NS1_I84A2Influenza A virus (strain A/Whale/Maine/328/1984 H13N2)
NS1_I33A0Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain ...
NS1_I000XInfluenza A virus (strain A/X-31 H3N2)

Non-structural protein NS-S

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NSS_BUNYWBunyamwera virus (BUNV) reference strain
NSS_RVFVZRift valley fever virus (strain ZH-548 M12) (RVFV) reference strain

Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)

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PA_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

pdb 3EBJ  3HW3  3HW4  3HW5  3HW6 

PA_I34A1Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

pdb 2ZNL 

PA_I60A0Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PA_I75A0Influenza A virus (strain A/Beijing/39/1975 H3N2)

Polymerase acidic protein

PA_I77AAInfluenza A virus (strain A/Brazil/11/1978 H1N1)
PA_I18A0Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus ...
PA_I02A0Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PA_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
PA_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PA_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PA_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PA_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PA_I83A5Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PA_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PA_I85A3Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PA_I83A1Influenza A virus (strain A/Chile/1/1983 H1N1)
PA_I96A3Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
PA_I56A1Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PA_I56A2Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PA_I49A1Influenza A virus (strain A/Duck/Germany/1949 H10N7)
PA_I80A6Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PA_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PA_I69A0Influenza A virus (strain A/England/878/1969 H3N2)
PA_I73A4Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PA_I86A3Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
PA_I47A0Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PA_I34A0Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PA_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PA_I79A7Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PA_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PA_I77AFInfluenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
PA_I80ADInfluenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PA_I36A0Influenza A virus (strain A/Henry/1936 H1N1)
PA_I40A0Influenza A virus (strain A/Hickox/1940 H1N1)
PA_I68A4Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
PA_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PA_I83A8Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PA_I80AAInfluenza A virus (strain A/India/6263/1980 H1N1)
PA_I57A0Influenza A virus (strain A/Japan/305/1957 H2N2)
PA_I93A0Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PA_I68A5Influenza A virus (strain A/Korea/426/1968 H2N2)
PA_I57A2Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PA_I57A1Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PA_I57A3Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PA_I54A2Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PA_I78A3Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PA_I71A1Influenza A virus (strain A/Memphis/1/1971 H3N2)
PA_I72A4Influenza A virus (strain A/Memphis/101/1972 H3N2)
PA_I72A3Influenza A virus (strain A/Memphis/102/1972 H3N2)
PA_I76A6Influenza A virus (strain A/Memphis/110/1976 H3N2)
PA_I78A8Influenza A virus (strain A/Memphis/18/1978 H3N2)
PA_I78A7Influenza A virus (strain A/Memphis/2/1978 H3N2)
PA_I80A4Influenza A virus (strain A/Memphis/4/1980 H3N2)
PA_I00A1Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PA_I68A6Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus ...
PA_I79A1Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)
PA_I73A5Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PA_I70A0Influenza A virus (strain A/Qu/7/1970 H3N2)
PA_I85A7Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PA_I06A0Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PA_I80A2Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
PA_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PA_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
PA_I57A5Influenza A virus (strain A/Singapore/1/1957 H2N2)
PA_I77A4Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PA_I82A4Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)
PA_I78A9Influenza A virus (strain A/Swine/Hong Kong/81/1978 H3N2)
PA_I30A0Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)

pdb 1YN6  1YN7 

PA_I77ADInfluenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
PA_I61A1Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
PA_I67A2Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
PA_I67A0Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PA_I83A4Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PA_I78ACInfluenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
PA_I80A8Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PA_I68A3Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PA_I66A1Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PA_I72A2Influenza A virus (strain A/Udorn/307/1972 H3N2)
PA_I51A0Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PA_I45A0Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PA_I43A0Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PA_I96A2Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PA_I35A3Influenza A virus (strain A/USA:Phila/1935 H1N1)
PA_I07A0Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PA_I77ABInfluenza A virus (strain A/USSR/90/1977 H1N1)
PA_I75A3Influenza A virus (strain A/Victoria/3/1975 H3N2)

pdb 2W69 

PA_I33A0Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain ...

pdb 4IUJ 

PA_I000XInfluenza A virus (strain A/X-31 H3N2)

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

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PB2_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB2_I34A1Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

pdb 2ZTT  3A1G  3CW4 

PB2_I60A0Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PB2_I75A0Influenza A virus (strain A/Beijing/39/1975 H3N2)
PB2_I77AAInfluenza A virus (strain A/Brazil/11/1978 H1N1)

Polymerase basic protein 2

PB2_I18A0Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus ...
PB2_I77AGInfluenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
PB2_I02A0Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PB2_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB2_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB2_I83A5Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PB2_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB2_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB2_I85A3Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PB2_I000FInfluenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain ...
PB2_I83A1Influenza A virus (strain A/Chile/1/1983 H1N1)
PB2_I96A3Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

Polymerase basic protein 2

PB2_I56A1Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PB2_I56A2Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PB2_I49A1Influenza A virus (strain A/Duck/Germany/1949 H10N7)
PB2_I80A6Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PB2_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB2_I69A0Influenza A virus (strain A/England/878/1969 H3N2)
PB2_I86A2Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)
PB2_I73A4Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PB2_I56A3Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
PB2_I47A0Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PB2_I34A0Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PB2_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB2_I79A7Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PB2_I84A4Influenza A virus (strain A/Gull/Astrakhan/227/1984 H13N6)
PB2_I77AFInfluenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
PB2_I80ADInfluenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PB2_I36A0Influenza A virus (strain A/Henry/1936 H1N1)

Polymerase basic protein 2

PB2_I40A0Influenza A virus (strain A/Hickox/1940 H1N1)

Polymerase basic protein 2

PB2_I68A4Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
PB2_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PB2_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB2_I83A8Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PB2_I80AAInfluenza A virus (strain A/India/6263/1980 H1N1)

Polymerase basic protein 2

PB2_I57A0Influenza A virus (strain A/Japan/305/1957 H2N2)
PB2_I79A4Influenza A virus (strain A/Kiev/59/1979 H1N1)
PB2_I93A0Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PB2_I68A5Influenza A virus (strain A/Korea/426/1968 H2N2)
PB2_I57A2Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PB2_I57A1Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PB2_I57A3Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PB2_I54A2Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

Polymerase basic protein 2

PB2_I78A3Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PB2_I71A1Influenza A virus (strain A/Memphis/1/1971 H3N2)
PB2_I72A4Influenza A virus (strain A/Memphis/101/1972 H3N2)
PB2_I72A3Influenza A virus (strain A/Memphis/102/1972 H3N2)
PB2_I76A6Influenza A virus (strain A/Memphis/110/1976 H3N2)
PB2_I78A8Influenza A virus (strain A/Memphis/18/1978 H3N2)
PB2_I78A7Influenza A virus (strain A/Memphis/2/1978 H3N2)
PB2_I80A4Influenza A virus (strain A/Memphis/4/1980 H3N2)
PB2_I88A3Influenza A virus (strain A/Memphis/8/1988 H3N2)
PB2_I00A1Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)

Polymerase basic protein 2

PB2_I68A6Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus ...
PB2_I73A5Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PB2_I70A0Influenza A virus (strain A/Qu/7/1970 H3N2)
PB2_I85A7Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PB2_I06A0Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

Polymerase basic protein 2

PB2_I80A2Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
PB2_I82A3Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)
PB2_I57A5Influenza A virus (strain A/Singapore/1/1957 H2N2)
PB2_I77A4Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PB2_I30A0Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PB2_I77ACInfluenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
PB2_I61A1Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

Polymerase basic protein 2

PB2_I67A2Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)

Polymerase basic protein 2

PB2_I02A7Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
PB2_I67A0Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PB2_I83A4Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PB2_I80A8Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PB2_I68A3Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PB2_I66A0Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
PB2_I66A1Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PB2_I72A2Influenza A virus (strain A/Udorn/307/1972 H3N2)
PB2_I51A0Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

Polymerase basic protein 2

PB2_I45A0Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

Polymerase basic protein 2

PB2_I43A0Influenza A virus (strain A/USA:Iowa/1943 H1N1)

Polymerase basic protein 2

PB2_I96A2Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

Polymerase basic protein 2

PB2_I35A3Influenza A virus (strain A/USA:Phila/1935 H1N1)

Polymerase basic protein 2

PB2_I07A0Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)

Polymerase basic protein 2

PB2_I77ABInfluenza A virus (strain A/USSR/90/1977 H1N1)
PB2_I75A3Influenza A virus (strain A/Victoria/3/1975 H3N2)

pdb 2GMO  2JDQ  2VQZ  2VY6  2VY7  2VY8 

PB2_I33A0Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain ...
PB2_I000XInfluenza A virus (strain A/X-31 H3N2)

Genome polyprotein

Select_all Deselect_all  
POLG_POL1SPoliovirus type 1 (strain Sabin)
POLG_POL2LPoliovirus type 2 (strain Lansing)

pdb 1EAH  3EPF 

POLG_POL2WPoliovirus type 2 (strain W-2)
POLG_POL32Poliovirus type 3 (strain 23127)
POLG_POL3LPoliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

pdb 1PIV  1PVC  1VBA  1VBB  1VBC  1VBE  3EPD  3IYB  3IYC 

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)

Select_all Deselect_all  
RDRP_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
RDRP_I34A1Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

pdb 2ZNL  2ZTT  3A1G 

RDRP_I60A0Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
RDRP_I56A0Influenza A virus (strain A/Beijing/11/1956 H1N1)
RDRP_I75A0Influenza A virus (strain A/Beijing/39/1975 H3N2)
RDRP_I77AAInfluenza A virus (strain A/Brazil/11/1978 H1N1)
RDRP_I18A0Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus ...
RDRP_I97A0Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
RDRP_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
RDRP_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
RDRP_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
RDRP_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
RDRP_I83A5Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
RDRP_I83A6Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
RDRP_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
RDRP_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
RDRP_I85A3Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
RDRP_I83A1Influenza A virus (strain A/Chile/1/1983 H1N1)
RDRP_I96A3Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
RDRP_I56A1Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
RDRP_I56A2Influenza A virus (strain A/Duck/England/1/1956 H11N6)
RDRP_I49A1Influenza A virus (strain A/Duck/Germany/1949 H10N7)
RDRP_I80A6Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
RDRP_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
RDRP_I73A6Influenza A virus (strain A/Dunedin/4/1973 H3N2)
RDRP_I69A0Influenza A virus (strain A/England/878/1969 H3N2)
RDRP_I73A4Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
RDRP_I86A3Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
RDRP_I47A0Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
RDRP_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
RDRP_I79A7Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
RDRP_I77AFInfluenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
RDRP_I80ADInfluenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
RDRP_I36A0Influenza A virus (strain A/Henry/1936 H1N1)
RDRP_I40A0Influenza A virus (strain A/Hickox/1940 H1N1)
RDRP_I68A4Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
RDRP_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

pdb 3CM8 

RDRP_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
RDRP_I83A8Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
RDRP_I80AAInfluenza A virus (strain A/India/6263/1980 H1N1)
RDRP_I57A0Influenza A virus (strain A/Japan/305/1957 H2N2)
RDRP_I79A4Influenza A virus (strain A/Kiev/59/1979 H1N1)
RDRP_I93A0Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
RDRP_I68A5Influenza A virus (strain A/Korea/426/1968 H2N2)
RDRP_I57A2Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
RDRP_I57A1Influenza A virus (strain A/Leningrad/134/1957 H2N2)
RDRP_I57A3Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
RDRP_I54A2Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
RDRP_I78A3Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
RDRP_I71A1Influenza A virus (strain A/Memphis/1/1971 H3N2)
RDRP_I72A4Influenza A virus (strain A/Memphis/101/1972 H3N2)
RDRP_I72A3Influenza A virus (strain A/Memphis/102/1972 H3N2)
RDRP_I76A6Influenza A virus (strain A/Memphis/110/1976 H3N2)
RDRP_I78A8Influenza A virus (strain A/Memphis/18/1978 H3N2)
RDRP_I78A7Influenza A virus (strain A/Memphis/2/1978 H3N2)
RDRP_I80A4Influenza A virus (strain A/Memphis/4/1980 H3N2)
RDRP_I88A3Influenza A virus (strain A/Memphis/8/1988 H3N2)
RDRP_I00A1Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
RDRP_I68A6Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus ...
RDRP_I73A5Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
RDRP_I70A0Influenza A virus (strain A/Qu/7/1970 H3N2)
RDRP_I06A0Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
RDRP_I80A2Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
RDRP_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
RDRP_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
RDRP_I57A5Influenza A virus (strain A/Singapore/1/1957 H2N2)
RDRP_I77A4Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
RDRP_I82A4Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)
RDRP_I81A4Influenza A virus (strain A/Swine/Ontario/2/1981 H1N1)
RDRP_I77ADInfluenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
RDRP_I61A1Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
RDRP_I67A2Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
RDRP_I02A7Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
RDRP_I67A0Influenza A virus (strain A/Tokyo/3/1967 H2N2)
RDRP_I83A4Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
RDRP_I78ACInfluenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
RDRP_I80A8Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
RDRP_I68A3Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
RDRP_I66A0Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
RDRP_I66A1Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
RDRP_I72A2Influenza A virus (strain A/Udorn/307/1972 H3N2)
RDRP_I51A0Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
RDRP_I45A0Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
RDRP_I43A0Influenza A virus (strain A/USA:Iowa/1943 H1N1)
RDRP_I96A2Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
RDRP_I35A3Influenza A virus (strain A/USA:Phila/1935 H1N1)
RDRP_I07A0Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
RDRP_I77ABInfluenza A virus (strain A/USSR/90/1977 H1N1)
RDRP_I75A3Influenza A virus (strain A/Victoria/3/1975 H3N2)
RDRP_I33A0Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain ...
RDRP_I88A7Influenza A virus (strain A/Wisconsin/3523/1988 H1N1)
RDRP_I000XInfluenza A virus (strain A/X-31 H3N2)

Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)

Select_all Deselect_all  
SHUT_ADEG1Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus ... reference strain
SHUT_ADE02Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain
SHUT_ADECCCanine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain ...
SHUT_ADECRCanine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 ...
SHUT_ADEGXFowl adenovirus C serotype 10 (strain SA2) (FAdV-10) (Fowl adenovirus 10)
SHUT_ADE12Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)
SHUT_ADE05Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
SHUT_ADE40Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)
SHUT_ADE41Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)
SHUT_ADEP3Porcine adenovirus A serotype 3 (PAdV-3) (Porcine adenovirus 3)

Protein E7


VE7_HPV16Human papillomavirus type 16 reference strain