Simplexvirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. The capsid consists of 162 capsomers and is surrounded by an amorphous tegument.

GENOME

Monopartite, linear, dsDNA genome of 152 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

All genes are transcribed by the host RNA polymerase II. and most mRNAs are unspliced. There are three temporal classes of genes: immediate-early (alpha), early (beta) and late (gamma). The immediate-early genes are transcribed immediately after infection to take control of cell defense and to activate early genes. These encode the proteins necessary for the viral DNA replication. The late genes mostly encode structural proteins. Latent genes can stop the replicative process at the early step. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral gB, gC, gD and gH proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Herpes simplex protein US12 binds specifically to transporters associated with antigen processing (TAP), blocking peptide-binding to TAP and subsequent loading of peptides onto MHC class I molecules . Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function .

Apoptosis modulation

The viral kinase US3 modulates host apoptosis in different ways. It activates host protein kinase A/PKA to block apoptosis. Additionally, it also interacts with programmed cell death protein 4 (PDCD4) and retains it in the nucleus thereby inhibiting host apoptosis .

Autophagy modulation

Herpes simplex virus ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein and thus blocking host autophagy process .

Cell-cycle modulation

The viral proteins ICP27 and vhs act jointly to repress host gene transcription and blocks the cell cycle at the G1 phase . In addition the UL24 protein induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

Herpes simplex virus inhibits the cascade leading to production of interferon-beta by targeting different cellular proteins. ICP34.5 forms a complex with host TBK1 and thus disrupts the interaction of TBK1-containing complexes with IRF3 . Another viral protein, ICP0, prevents IRF3 activation and subsequent induction of IFN-beta expression .

Host splicing inhibition

HSV-1 ICP27 is an alternative splicing regulator of host mRNA. It has been shown to act as a splicing silencer at the 3’ splice site of the PML intron 7a .

Matching UniProtKB/Swiss-Prot entries

230 entries grouped by protein (browse by keywords)

All proteins are shown (view only 146 complete proteome entries)

Alkaline nuclease (EC 3.1.-.-)

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AN_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
AN_HHV2Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2)

Cytoplasmic envelopment protein 1

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CEP1_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CEP1_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Cytoplasmic envelopment protein 2

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CEP2_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CEP2_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Cytoplasmic envelopment protein 3

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CEP3_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CEP3_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
CEP3_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)

Capsid vertex component 1

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CVC1_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CVC1_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Capsid vertex component 2

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CVC2_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CVC2_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Major DNA-binding protein

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DNBI_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
DNBI_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
DNBI_BHV2BBovine herpesvirus 2 (strain BMV) (BoHV-2) (Bovine mammillitis virus)
DNBI_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
DNBI_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
DNBI_HHV2Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2)

DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)

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DPOL_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
DPOL_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
DPOL_HHV1AHuman herpesvirus 1 (strain Angelotti) (HHV-1) (Human herpes simplex virus 1)
DPOL_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
DPOL_HHV1SHuman herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus 1)
DPOL_HHV21Human herpesvirus 2 (strain 186) (HHV-2) (Human herpes simplex virus 2)

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

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DUT_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
DUT_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Envelope protein UL45 (18 kDa protein)

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EV45_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
EV45_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
EV45_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
EV45_HHV1MHuman herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
EV45_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein B (gB)

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GB_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GB_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GB_BHV2BBovine herpesvirus 2 (strain BMV) (BoHV-2) (Bovine mammillitis virus)
GB_HSV2SHerpes simplex virus type 2 (strain SA8) (Simian agent 8)
GB_HSVA1Herpesvirus ateles type 1 (strain Lennette)
GB_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
GB_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GB_HHV1PHuman herpesvirus 1 (strain Patton) (HHV-1) (Human herpes simplex virus 1)
GB_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
GB_SHV1Saimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset herpesvirus)

Envelope glycoprotein C

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GC_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GC_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GC_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GC_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
GC_HHV2GHuman herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein C (Glycoprotein F)

Envelope glycoprotein D (gD)

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GD_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GD_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GD_CHV1Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)
GD_HHV1AHuman herpesvirus 1 (strain Angelotti) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1HHuman herpesvirus 1 (strain HZT) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1PHuman herpesvirus 1 (strain Patton) (HHV-1) (Human herpes simplex virus 1)
GD_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein E (gE) (gE-1)

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GE_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GE_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Envelope glycoprotein E (gE) (gE-2)

GE_CHV1Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)

Envelope glycoprotein E (gE)

GE_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Envelope glycoprotein G (gG) (gG-2)

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GG_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

Envelope glycoprotein G (gG) (gG-1)

GG_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GG_HHV2BHuman herpesvirus 2 (strain B4327UR) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein H (gH)

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GH_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GH_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GH_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
GH_HHV1EHuman herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

Envelope glycoprotein I (gI)

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GI_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GI_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GI_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein J

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GJ_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GJ_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Envelope glycoprotein K (Syncytial protein)

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GK_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GK_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GK_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GK_HHV1MHuman herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
GK_HHV1RHuman herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)
GK_HHV19Human herpesvirus 1 (strain R19) (HHV-1) (Human herpes simplex virus 1)

Envelope glycoprotein L (gL)

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GL_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GL_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GL_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)

Envelope glycoprotein M (gM)

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GM_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GM_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Envelope glycoprotein N

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GN_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GN_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

DNA replication helicase (EC 3.6.4.-)

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HELI_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
HELI_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)

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HEPA_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
HEPA_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) (RING-type E3 ubiquitin transferase ICP0) (Trans-acting transcriptional protein ICP0) (VMW110)

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ICP0_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP0_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 protein)

Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

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ICP22_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP22_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)

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ICP27_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP27_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP27_HHV1EHuman herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27)

Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

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ICP34_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP34_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP34_HHV1DHuman herpesvirus 1 (strain CVG-2) (HHV-1) (Human herpes simplex virus 1)
ICP34_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
ICP34_HHV1NHuman herpesvirus 1 (strain MGH-10) (HHV-1) (Human herpes simplex virus 1)

Major viral transcription factor ICP4 (Alpha-4 protein) (Infected cell protein 4) (Transcriptional activator IE175)

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ICP4_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP4_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Major viral transcription factor ICP4 homolog (Alpha-4 protein) (Infected cell protein 4) (Transcriptional activator IE175)

ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)

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ICP47_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP47_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP47_CHV1ECercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)
ICP47_CHV16Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2)
ICP47_HSV2SHerpes simplex virus type 2 (strain SA8) (Simian agent 8)

Inner tegument protein

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ITP_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ITP_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Thymidine kinase (EC 2.7.1.21)

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KITH_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
KITH_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
KITH_BHV2HBovine herpesvirus 2 (strain BHM-1) (BoHV-2) (Bovine mammillitis virus)
KITH_HHV1Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
KITH_HHV1CHuman herpesvirus 1 (strain CL101) (HHV-1) (Human herpes simplex virus 1)
KITH_HHV1EHuman herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)
KITH_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
KITH_HHV1SHuman herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus 1)
KITH_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
KITH_SHV1Saimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset herpesvirus)

Latency-related protein 1


LRP1_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Latency-related protein 2


LRP2_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

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LTP_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
LTP_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Membrane protein UL43

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MB43_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
MB43_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Major capsid protein (MCP)

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MCP_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
MCP_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Nuclear egress protein 1

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NEC1_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
NEC1_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Nuclear egress protein 2

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NEC2_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
NEC2_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Nuclear phosphoprotein UL3

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NP03_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
NP03_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
NP03_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
NP03_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

Nuclear protein UL4

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NP04_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
NP04_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Replication origin-binding protein (OBP) (OriBP)

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OBP_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
OBP_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP)

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PAP_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
PAP_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Portal protein

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PORTL_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
PORTL_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

DNA primase (EC 2.7.7.-)

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PRIM_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
PRIM_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

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RIR1_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
RIR1_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
RIR1_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

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RIR2_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
RIR2_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
RIR2_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
RIR2_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

RNA-binding protein (Vmw21)

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RNB_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
RNB_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Probable RNA-binding protein

RNB_HHV1MHuman herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural protein UL26)

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SCAF_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
SCAF_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Small capsomere-interacting protein

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SCP_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
SCP_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Virion host shutoff protein (Vhs) (EC 3.1.27.-)

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SHUT_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
SHUT_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
SHUT_HHV1KHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
SHUT_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
SHUT_HHV2GHuman herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

Tegument protein UL46 (Tegument protein VP11/12)

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TEG1_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG1_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TEG1_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Tegument protein UL14

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TEG3_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG3_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Tegument protein UL21

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TEG4_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG4_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TEG4_HHV1EHuman herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

Tegument protein UL47 (82/81 kDa tegument protein) (VMW82/81) (VP13/14)

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TEG5_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG5_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TEG5_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Tegument protein UL55

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TEG6_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG6_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TEG6_HHV1EHuman herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

Tegument protein UL51

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TEG7_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG7_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Tripartite terminase subunit 1

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TRM1_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRM1_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TRM1_BHV2BBovine herpesvirus 2 (strain BMV) (BoHV-2) (Bovine mammillitis virus)
TRM1_HHV1AHuman herpesvirus 1 (strain Angelotti) (HHV-1) (Human herpes simplex virus 1)
TRM1_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Tripartite terminase subunit 2

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TRM2_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRM2_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

Select_all Deselect_all  
TRM3_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRM3_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Triplex capsid protein 1

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TRX1_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRX1_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TRX1_HHV14Human herpesvirus 1 (strain A44) (HHV-1) (Human herpes simplex virus 1)
TRX1_HHV2GHuman herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

Triplex capsid protein 2

Select_all Deselect_all  
TRX2_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRX2_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Serine/threonine-protein kinase UL13 (EC 2.7.11.1) (Virion protein VMW57)

Select_all Deselect_all  
UL13_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL13_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Serine/threonine-protein kinase UL13 (EC 2.7.11.1)

Protein UL20

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UL20_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL20_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Protein UL24

Select_all Deselect_all  
UL24_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL24_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Packaging protein UL32

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UL32_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL32_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Protein UL56

Select_all Deselect_all  
UL56_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL56_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
UL56_HHV1EHuman herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

Select_all Deselect_all  
UNG_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UNG_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
UNG_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

Protein US2

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US02_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US02_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Serine/threonine-protein kinase US3 (EC 2.7.11.1)

Select_all Deselect_all  
US03_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US03_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Virion protein US10

Select_all Deselect_all  
US10_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US10_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
US10_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

Protein US8.5

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US8A_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US8A_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
US8A_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

US8.5 protein

Envelope protein US9 (10 kDa protein)

Select_all Deselect_all  
US9_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US9_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
US9_CHV1Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)

Envelope protein US9 homolog (10 kDa protein)

Envelope glycoprotein J


VGLJ_CHV1Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)

Tegument protein VP16 (Alpha trans-inducing protein) (Alpha-TIF) (ICP25) (Vmw65)

Select_all Deselect_all  
VP16_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
VP16_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
VP16_HHV1FHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
VP16_HHV23Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

Tegument protein VP22

Select_all Deselect_all  
VP22_HHV11Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
VP22_HHV2HHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain