Cytomegalovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachement of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Many HCMV proteins are dedicated to interfere with the host adaptive immune system. HCMV US11 reverse the translocation of human class I heavy chains from the host endoplasmic reticulum (ER) back to the cytosol which ultimately results in their degradation by the proteasome. US2 destroys two components of the MHC class II pathway, HLA-DR-alpha and DM-alpha, preventing recognition by CD4+ T cells. US3 prevents forward transport and maturation of all major histocompatibility complex (MHC) class I molecules by trapping them in the ER. HCMV US6 inhibits expression of MHC class I on the cell surface through TAP (specific transporters associated with antigen presentation) by blocking translocation of peptides from the proteasome into the ER for loading onto MHC class I.

Apoptosis modulation

Viral inhibitor of caspase-8-induced apoptosis (from gene UL36) plays a role in the inhibition of apoptosis by interacting with the pro-domain of pro-caspase-8/CASP8 and thus preventing its activation . Another viral protein vMIA inhibits BAX- but not BAK- mediated apoptosis.

Autophagy modulation

The human cytomegalovirus protein TRS1 inhibits host autophagy process via its interaction with Beclin 1 .

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. HCMV encodes an UL24 homolog that should fullfill this role .

Innate immune response inhibition

HCMV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the viral pp65 protein .
NK cells are a component of the innate immune system which play an important role in the early control of viral infections and also help to drive subsequent adaptive immunity. Several HCMV proteins are involved in the inhibition of NK-cells cytotoxicity including UL16 or UL142 that retain NKGCD2 ligands inside the cell to prevent their cell surface expression .

Host splicing inhibition

HCMV UL69 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

403 entries grouped by protein (browse by keywords)

All proteins are shown (view only 369 complete proteome entries)

Alkaline nuclease (EC 3.1.-.-)

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AN_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
AN_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Cytoplasmic envelopment protein 1

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CEP1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
CEP1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Cytoplasmic envelopment protein 2

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CEP2_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
CEP2_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Cytoplasmic envelopment protein 3

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CEP3_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
CEP3_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Cytoplasmic envelopment protein 3 (28 kDa structural phosphoprotein) (pp28)

Capsid vertex component 1

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CVC1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
CVC1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Capsid vertex component 2

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CVC2_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
CVC2_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Chemokine vCXCL1


CXCL1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Major DNA-binding protein

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DNBI_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
DNBI_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
DNBI_SCMVCSimian cytomegalovirus (strain Colburn)

DNA polymerase catalytic subunit (EC 2.7.7.7)

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DPOL_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
DPOL_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
DPOL_RHCM6Rhesus cytomegalovirus (strain 68-1) (RhCMV)

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

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DUT_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
DUT_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Early phosphoprotein p84

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EP84_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
EP84_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Envelope glycoprotein B (gB)

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GB_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GB_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
GB_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
GB_RHCM6Rhesus cytomegalovirus (strain 68-1) (RhCMV)

Envelope glycoprotein H (gH)

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GH_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GH_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
GH_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Envelope glycoprotein L (gL)

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GL_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GL_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
GL_HCMV2Human cytomegalovirus (strain 1042) (HHV-5) (Human herpesvirus 5)
GL_HCMV1Human cytomegalovirus (strain 119) (HHV-5) (Human herpesvirus 5)
GL_HCMV3Human cytomegalovirus (strain 2387) (HHV-5) (Human herpesvirus 5)
GL_HCMV4Human cytomegalovirus (strain 4654) (HHV-5) (Human herpesvirus 5)
GL_HCMV5Human cytomegalovirus (strain 5035) (HHV-5) (Human herpesvirus 5)
GL_HCMV6Human cytomegalovirus (strain 5040) (HHV-5) (Human herpesvirus 5)
GL_HCMV7Human cytomegalovirus (strain 5160) (HHV-5) (Human herpesvirus 5)
GL_HCMV8Human cytomegalovirus (strain 5508) (HHV-5) (Human herpesvirus 5)
GL_HCMVPHuman cytomegalovirus (strain PT) (HHV-5) (Human herpesvirus 5)

Envelope glycoprotein M (gM)

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GM_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GM_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Envelope glycoprotein N

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GN_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GN_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Glycoprotein O (gO)

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GO_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GO_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Envelope glycoprotein O

DNA replication helicase (EC 3.6.4.-)

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HELI_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
HELI_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)

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HEPA_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
HEPA_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

mRNA export factor ICP27 homolog

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ICP27_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
ICP27_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

45 kDa immediate-early protein 2 (IE2)


IE247_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Viral interleukin-10 homolog (cmvIL-10) (vIL-10)

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IL10H_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
IL10H_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein HKLF1 (IRL1) (TRL1)

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IR01_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
IR01_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL2 (TRL2)


IR02_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL3 (TRL3)


IR03_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL4 (TRL4)


IR04_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL5 (TRL5)


IR05_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL6 (TRL6)

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IR06_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
IR06_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL7 (TRL7)


IR07_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL8 (TRL8)


IR08_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL9 (TRL9)


IR09_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Protein IRL10 (TRL10)

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IR10_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
IR10_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Viral Fc-gamma receptor-like protein IR11 (gp34)


IR11_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL12 (TRL12)


IR12_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL13 (TRL13)


IR13_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein IRL14


IR14_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Protein IRS1 (HQRF1)

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IRS1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
IRS1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein IRS1

Inner tegument protein

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ITP_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
ITP_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein HKRFX (J1I)


J1I_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein J1L


J1L_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein J1S


J1S_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

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LTP_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
LTP_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
LTP_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Major capsid protein (MCP)

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MCP_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
MCP_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Nuclear egress protein 1

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NEC1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
NEC1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Nuclear egress protein 2

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NEC2_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
NEC2_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Portal protein

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PORTL_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
PORTL_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Large structural phosphoprotein (150 kDa matrix phosphoprotein) (150 kDa phosphoprotein) (pp150) (Basic phosphoprotein) (BPP) (Phosphoprotein UL32) (Tegument protein UL32)

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PP150_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
PP150_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein pp150

65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein UL83)

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PP65_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
PP65_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
PP65_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

65 kDa phosphoprotein (pp65) (64 kDa matrix phosphoprotein) (pp64) (GP64) (Phosphoprotein UL83) (Tegument protein UL83)

Protein pp71 (pp71) (71 kDa upper matrix phosphoprotein) (Phosphoprotein UL82) (ppUL82) (Tegument protein UL82)

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PP71_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
PP71_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein pp71

Phosphoprotein 85 (pp85) (Phosphoprotein UL25)

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PP85_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
PP85_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

DNA primase (EC 2.7.7.-)

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PRIM_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
PRIM_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
PRIM_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Ribonucleoside-diphosphate reductase large subunit-like protein

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RIR1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
RIR1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein RL11


RL11_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein RL12


RL12_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane protein RL13


RL13_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein RL5A


RL5A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein RL8A


RL8A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein RL9A


RL9A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)

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SCAF_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Capsid scaffolding protein (Protease precursor) (pPR)

SCAF_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
SCAF_SCMVCSimian cytomegalovirus (strain Colburn)

Small capsomere-interacting protein

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SCP_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
SCP_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein UL51 homolog

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TEG7_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
TEG7_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein (67 kDa phosphorylated protein)


TEGU_HCMVHuman cytomegalovirus (HHV-5) (Human herpesvirus 5)

Protein TRL14


TR14_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Tripartite terminase subunit 1

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TRM1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
TRM1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tripartite terminase subunit 2

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TRM2_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
TRM2_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

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TRM3_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
TRM3_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein HHLF1

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TRS1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
TRS1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein TRS1

Triplex capsid protein 1

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TRX1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
TRX1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Triplex capsid protein 2

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TRX2_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
TRX2_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL131A


U131A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL147A


U147A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL148A


U148A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL148B


U148B_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL148C


U148C_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL148D


U148D_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL150A


U150A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Glycoprotein UL1

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UL01_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL01_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL2

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UL02_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL02_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL3


UL03_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Early glycoprotein GP48

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UL04_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL04_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Envelope glycoprotein UL4

UL04_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Protein UL5

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UL05_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL05_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL6

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UL06_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL06_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

CEACAM1-like protein UL7

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UL07_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL07_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL8


UL08_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL9

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UL09_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL09_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein UL9

Uncharacterized protein UL10

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UL10_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL10_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL101


UL101_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL106


UL106_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL107


UL107_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL108


UL108_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL109


UL109_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL110


UL110_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL116

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UL116_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL116_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL117

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UL117_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL117_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL117 (pUL117)

Viral Fc-gamma receptor-like protein UL119 (gp68)

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UL119_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL119_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL11

Select_all Deselect_all  
UL11P_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL11P_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL12


UL12_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL120

Select_all Deselect_all  
UL120_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL120_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane protein UL120

Membrane protein UL121

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UL121_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL121_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL124

Select_all Deselect_all  
UL124_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL124_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL125


UL125_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL126


UL126_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL127


UL127_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL128


UL128_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL129


UL129_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL13

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UL13_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL13_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL130

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UL130_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL130_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Envelope glycoprotein UL130

Uncharacterized protein UL131


UL131_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Envelope glycoprotein UL132 (L3)

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UL132_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL132_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Envelope glycoprotein UL132

UL132_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Protein UL133


UL133_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL135

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UL135_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL135_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Protein UL136

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UL136_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL136_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Protein UL138


UL138_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein UL139


UL139_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL14

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UL14_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL14_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL140


UL140_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL141


UL141_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein UL142


UL142_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)

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UL144_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL144_HCMVOHuman cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

Protein UL145


UL145_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Putative viral CXC chemokine 2 (vCXCL2)

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UL147_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL147_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Membrane protein UL148


UL148_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL150


UL150_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL15A

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UL15A_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL15A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL16

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UL16P_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL16P_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL17

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UL17_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL17

UL17_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL17_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Glycoprotein UL18

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UL18_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL18_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein UL18

Uncharacterized protein UL19

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UL19_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL19_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL20

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UL20_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL20_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane protein UL20

Uncharacterized protein UL21


UL21_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL21A

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UL21A_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL21A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Glycoprotein UL22A

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UL22A_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL22A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein UL23

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UL23_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL23_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein UL26

Select_all Deselect_all  
UL26_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL26_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL27

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UL27_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL27_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL28


UL28_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL29


UL29_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL29/28

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UL298_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL298_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Protein UL29/UL28

Uncharacterized protein UL30

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UL30_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL30_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL31

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UL31_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL31_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

G-protein coupled receptor homolog UL33 (vGPCR UL33)

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UL33_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL33_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

G-protein coupled receptor homolog UL33

Transcriptional regulator UL34

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UL34_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL34_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL34_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Protein UL35

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UL35_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL35_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein UL35

Uncharacterized protein UL36


UL36_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Apoptosis inhibitor UL38

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UL38_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL38_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL39


UL39_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL40

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UL40_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL40_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL41


UL41_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL41A

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UL41A_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL41A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL42

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UL42_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL42_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL42

Tegument protein UL43

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UL43_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL43_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL49 (Protein HFLF5)

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UL49_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL49_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL49

Packaging protein UL32 homolog (Protein HFRF1)

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UL52_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL52_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Packaging protein UL32 homolog

Uncharacterized protein UL58


UL58_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL59


UL59_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL60


UL60_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL61


UL61_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL62


UL62_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL63


UL63_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL64


UL64_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL65


UL65_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL66


UL66_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL67


UL67_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL68


UL68_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL74A


UL74A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL76

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UL76_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL76_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL78

Select_all Deselect_all  
UL78_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL78_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL78

Protein UL79

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UL79_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL79_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL81


UL81_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL84

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UL84_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL84_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL84_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

UL84 protein

Protein UL87

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UL87_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL87_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL87

Protein UL88

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UL88_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL88_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL90


UL90_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL91

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UL91_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL91_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein UL92

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UL92_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL92_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL92

Protein UL95

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UL95_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL95_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
UL95_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Protein UL96

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UL96_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL96_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Serine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase) (HSRF3 protein)

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UL97_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL97_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Serine/threonine protein kinase UL97 (EC 2.7.1.-)

UL97_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Serine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase)

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

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UNG_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UNG_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein HQLF3

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US01_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US01_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein US1

Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)

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US02_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US02_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
US02_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Unique short US2 glycoprotein (HQLF2) (gpUS2)

Membrane glycoprotein US3

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US03_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein US3 (Glycoprotein E) (Protein HQLF1) (gpUS3 IE)

US03_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
US03_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Uncharacterized protein US4


US04_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein US5

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US05_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US05_HCMVOHuman cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

Unique short US6 glycoprotein (Protein HXLF6) (gpUS6)

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US06_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US06_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Unique short US6 glycoprotein

US06_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Unique short US6 glycoprotein (HXLF6) (gpUS6)

Unique short US7 glycoprotein (Protein HXLF5) (gpUS7)

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US07_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US07_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein US7

Unique short US8 glycoprotein (Protein HXLF4) (gpUS8)

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US08_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US08_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein US8

Unique short US9 glycoprotein (Protein HXLF3) (gpUS9)

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US09_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US09_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein US9

Unique short US10 glycoprotein (Protein HXLF2) (gpUS10)

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US10_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US10_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein US10

Unique short US11 glycoprotein (Protein HXLF1) (gpUS11)

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US11_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US11_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane glycoprotein US11

US11_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Unique short US11 glycoprotein (HXLF1) (gpUS11)

Uncharacterized protein HVLF6

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US12_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US12_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein US12

Uncharacterized protein HVLF5

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US13_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US13_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane protein US13

Uncharacterized protein HVLF4

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US14_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US14_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane protein US14

Uncharacterized protein HVLF3

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US15_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US15_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane protein US15

Uncharacterized protein HVLF2

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US16_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US16_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein US16

Uncharacterized protein HVLF1

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US17_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US17_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein US17

Transmembrane protein US18

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US18_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US18_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
US18_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Transmembrane protein HWLF5

Transmembrane protein HWLF4

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US19_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US19_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Transmembrane protein US19

US19_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Transmembrane protein HWLF3

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US20_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US20_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane protein US20

US20_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Uncharacterized protein HWLF2

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US21_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US21_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Membrane protein US21

Early nuclear protein HWLF1 (Tegument protein US22)

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US22_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US22_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein US22

Tegument protein US23 (Protein HHLF7)

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US23_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US23_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein US23

Tegument protein US24 (Protein HHLF6)

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US24_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US24_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein US24

Uncharacterized protein US25


US25_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein HHLF5

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US26_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US26_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein US26

G-protein coupled receptor homolog US27 (HHRF2)

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US27_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US27_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Envelope glycoprotein US27

G-protein coupled receptor homolog US28 (HHRF3)

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US28_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US28_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Envelope protein US28

US28_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Uncharacterized protein HHRF4

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US29_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US29_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein US29

Uncharacterized protein HHRF5

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US30_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US30_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein US30

Uncharacterized protein HHRF6

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US31_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US31_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein US31

Uncharacterized protein HHRF7

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US32_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US32_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein US32

Uncharacterized protein HHLF3


US33_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein US33A


US33A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Protein US34

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US34_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US34_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein US34A

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US34A_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
US34A_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein HHLF2


US35_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein US36


US36_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

30 kDa major early protein


V30K_HCMVEHuman cytomegalovirus (strain Eisenhardt) (HHV-5) (Human herpesvirus 5)

UL37 immediate early glycoprotein

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VGLI_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
VGLI_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Viral inhibitor of caspase-8-induced apoptosis (vICA)


VICA_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

55 kDa immediate-early protein 1 (IE1)

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VIE1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
VIE1_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

55 kDa immediate-early protein 1

VIE1_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Viral transcription factor IE2 (IE2) (Protein UL122)

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VIE2_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
VIE2_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
VIE2_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

30 kDa immediate-early protein 2 (IE2)


VIE3_HCMVTHuman cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Protein UL24

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VP22_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
VP22_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein UL24

DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)

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VPAP_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
VPAP_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein HHLF4


YHL4_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Uncharacterized protein HHRF1


YHR1_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)