Roseolovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Occasionally, the viral genome can be integrated in host chromosome thereby creating a latent virus.
  5. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  6. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  7. A first round of circular genome amplification occurs by bidirectional replication
  8. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  9. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  10. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

The HHV-6 U24 protein downregulates the T-cell receptor complex and impairs T-cell activation.

Cell-cycle modulation

The UL24 protein homolog induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

HHV-6 protein IE1 interferes with the binding of IRF3 to the IFN-beta promoter, reduces levels of dimerized IRF3 and nucleus-translocated IRF3 in response to activation by TBK1. This inhibiton of the pathway through IRF3 subsequenty prevents the expression IFN-beta.

Host splicing inhibition

HHV-6 UL42 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

273 entries grouped by protein (browse by keywords)

All proteins are shown (view only 259 complete proteome entries)

Alkaline nuclease (EC 3.1.-.-)

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AN_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
AN_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
AN_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein B1


B1_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein B2


B2_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein B3


B3_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein B4


B4_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein B5


B5_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein B6


B6_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein B7


B7_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein B8


B8_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein B9


B9_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Putative CC-type chemokine U83

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CCU83_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
CCU83_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

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DEN_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
DEN_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
DEN_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

Deneddylase (EC 3.4.19.12) (EC 3.4.22.-) (Ubiquitin thioesterase)

DEN_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Deneddylase (EC 3.4.19.12) (EC 3.4.22.-) (Ubiquitin thioesterase)

Major DNA-binding protein (MDBP)

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DNBI_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
DNBI_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
DNBI_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

DNA polymerase catalytic subunit (EC 2.7.7.7)

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DPOL_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
DPOL_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
DPOL_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Uncharacterized protein DR1

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DR1_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
DR1_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein DR2


DR2_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Uncharacterized protein DR3

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DR3_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
DR3_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein DR4


DR4_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Uncharacterized protein DR5


DR5_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Uncharacterized protein DR6

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DR6_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
DR6_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein DR7


DR7_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Uncharacterized protein DR8


DR8_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

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DUT_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
DUT_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
DUT_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
DUT_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Envelope glycoprotein B (gB)

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GB_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
GB_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GB_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
GB_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Probable ganciclovir kinase (EC 2.7.1.-)

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GCVK_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
GCVK_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GCVK_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Envelope glycoprotein H (gH)

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GH_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
GH_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GH_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
GH_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Envelope glycoprotein L

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GL_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
GL_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GL_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Envelope glycoprotein M (gM)

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GM_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
GM_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GM_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Glycoprotein N (gN)

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GN_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
GN_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GN_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Glycoprotein 105 (gp105)

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GP105_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Glycoprotein 105 (gp105) (HCLF1 protein)

GP105_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GP105_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

DNA replication helicase (EC 3.6.4.-)

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HELI_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
HELI_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
HELI_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

DNA helicase/primase complex-associated protein

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HEPA_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
HEPA_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
HEPA_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

mRNA export factor ICP27 homolog

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ICP27_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
ICP27_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
ICP27_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Immediate-early protein 1 (IE1) (Protein RF2/RF3/RF4) (pRF2/pRF3/pRF4)


IE1_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Immediate-early protein 2 (IE2)

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IE2_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
IE2_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
IE2_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

Uncharacterized protein LJ1


LJ1_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Major capsid protein (MCP)

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MCP_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
MCP_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Major capsid protein

MCP_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Replication origin-binding protein (OBP)

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OBP_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
OBP_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
OBP_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Putative OX-2 membrane glycoprotein homolog (Protein U85)

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OX2V_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
OX2V_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Large structural phosphoprotein (100 kDa phosphoprotein) (pp100) (Major antigenic structural protein)

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P100_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
P100_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
P100_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Large structural phosphoprotein (100 kDa phosphoprotein) (pp100)

Portal protein UL6 homolog

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PORTL_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
PORTL_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
PORTL_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Phosphoprotein 85 (pp85) (Protein U14)

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PP85_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
PP85_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

DNA primase (EC 2.7.7.-)

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PRIM_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
PRIM_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
PRIM_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Ribonucleoside-diphosphate reductase large subunit-like protein U28

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RIR1_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
RIR1_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
RIR1_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein RJ1 (Protein LT1)


RJ1_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)

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SCAF_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
SCAF_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
SCAF_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Tegument protein UL11 homolog

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TEG2_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
TEG2_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
TEG2_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Tripartite terminase subunit UL28 homolog

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TRM1_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
TRM1_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
TRM1_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Tripartite terminase subunit UL33 homolog

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TRM2_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
TRM2_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Tripartite terminase subunit UL15 homolog (DNA-packaging protein U66/U60) (Terminase large subunit)

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TRM3_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
TRM3_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
TRM3_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Uncharacterized protein U1


U1_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Protein U10


U10_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein U13

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U13_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U13_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein U15

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U15_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U15_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U15

Protein U17/U16

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U16_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U16_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

Protein U17

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U17_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U17_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
U17_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

Putative immediate early glycoprotein (Protein U18)

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U18_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U18_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein U19

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U19_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U19_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Glycoprotein U20

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U20_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U20_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

U21 glycoprotein

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U21_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Glycoprotein U21

U21_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
U21_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
U21_HHV7RHuman herpesvirus 7 (strain RK) (HHV-7) (Human T lymphotropic virus)

U21 glycoprotein (gp60)

Glycoprotein U22

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U22_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U22_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U22

Glycoprotein U23

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U23_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U23_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U23

Glycoprotein U24

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U24_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U24_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U24

Uncharacterized protein U24A


U24A_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein U32

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U32_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U32_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein U6

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U6_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U6_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein U61


U61_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Uncharacterized protein U78


U78_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Protein U79/U80

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U79_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U79_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U79

U79_HHV6HHuman herpesvirus 6B (strain HST) (HHV-6 variant B) (Human B lymphotropic virus)
U79_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U79

Uncharacterized protein U88


U88_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Protein U90


U90_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Uncharacterized protein U91

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U91_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U91_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U91

Uncharacterized protein U95

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U95_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
U95_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Virion egress protein UL7 homolog

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UL07_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL07_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL07_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Capsid-binding protein UL16

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UL16_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

Capsid-binding protein UL16 homolog

UL16_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL16_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Virion-packaging protein UL17 homolog

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UL17_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL17_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL17_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein UL24 homolog

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UL24_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL24_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL24_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
UL24_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Virion-packaging protein UL25 homolog

Select_all Deselect_all  
UL25_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL25_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL25_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Virion egress protein UL31 homolog

Select_all Deselect_all  
UL31_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL31_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL31_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Packaging protein UL32

Select_all Deselect_all  
UL32_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL32_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Packaging protein UL32 homolog

UL32_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

G-protein coupled receptor homolog U12

Select_all Deselect_all  
UL33_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL33_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Virion egress protein UL34 homolog (Primary envelopment factor UL34 homolog)

Select_all Deselect_all  
UL34_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL34_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL34_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Capsid assembly protein UL37 homolog

Select_all Deselect_all  
UL37_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL37_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL37_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U33

Select_all Deselect_all  
UL49_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL49_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL49_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U44

Select_all Deselect_all  
UL71_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL71_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL71_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U52

Select_all Deselect_all  
UL79_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL79_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL79_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U58

Select_all Deselect_all  
UL87_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL87_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL87_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U59

Select_all Deselect_all  
UL88_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL88_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL88_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U62

Select_all Deselect_all  
UL91_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL91_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL91_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U63

Select_all Deselect_all  
UL92_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL92_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL92_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U67

Select_all Deselect_all  
UL95_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL95_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL95_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U68

Select_all Deselect_all  
UL96_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UL96_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL96_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)

Select_all Deselect_all  
UNG_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
UNG_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UNG_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Uncharacterized protein U55A


V55A_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Uncharacterized protein U55B


V55B_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

G-protein coupled receptor


VGCR_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Triplex capsid protein VP19C homolog (Minor capsid protein)

Select_all Deselect_all  
VP19_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VP19_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Triplex capsid protein VP19C homolog

VP19_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Triplex capsid protein VP19C (Minor capsid protein)

Triplex capsid protein VP23 homolog

Select_all Deselect_all  
VP23_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VP23_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VP23_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
VP23_HHV7MHuman herpesvirus 7 (strain MUK) (HHV-7) (Human T lymphotropic virus)

Triplex capsid protein U56

DNA polymerase processivity factor (Phosphoprotein P41) (PP41) (Polymerase accessory protein) (PAP)

Select_all Deselect_all  
VPAP_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VPAP_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VPAP_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

DNA polymerase processivity factor (Polymerase accessory protein) (PAP)

Protein U1


VU1_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain

U10 protein

Select_all Deselect_all  
VU10_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU10_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U2


VU2_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U25

Select_all Deselect_all  
VU25_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU25_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU25_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U26

Select_all Deselect_all  
VU26_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU26_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU26_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
VU26_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U3

Select_all Deselect_all  
VU3_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU3_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU3_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U4

Select_all Deselect_all  
VU4_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU4_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU4_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Glycoprotein U47

Select_all Deselect_all  
VU47_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU47_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU47_HHV6GHuman herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
VU47_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Glycoprotein U47 homolog

Protein U5

Select_all Deselect_all  
VU5_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU5_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

G-protein coupled receptor homolog U51

Select_all Deselect_all  
VU51_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU51_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU51_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U54

Select_all Deselect_all  
VU54_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU54_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU54_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Uncharacterized protein U55

Select_all Deselect_all  
VU55_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU55_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U7

Select_all Deselect_all  
VU7_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU7_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U8

Select_all Deselect_all  
VU8_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU8_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU8_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U84

Select_all Deselect_all  
VU84_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU84_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU84_HHV7JHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Protein U9

Select_all Deselect_all  
VU9_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU9_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U94

Select_all Deselect_all  
VU94_HHV6UHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B ... reference strain
VU94_HHV6ZHuman herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain