Lymphocryptovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Epstein-Barr virus protein BNLF2a inhibits host adaptive immune response by interacting with TAP1 and TAP2 and thus preventing TAP-mediated peptide transport and subsequent loading. The glycine-alanine repeat domain (GAr) of Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1) prevents major histocompatibility complex (MHC) class I-restricted presentation of EBNA1 epitopes to cytotoxic T cells.

Apoptosis modulation

Epstein-Barr viral protein BHRF1 is a viral homologue of the Bcl-2 oncogene that is able to protect cells from induced apoptosis. EBNA3C directly interacts with host Gemin3 and thereby blocks p53-mediated apoptosis .

Autophagy modulation

The viral Bcl-2 homolog BHRF1 in addition to prevent host cel death, may also control host autophagy .

Cell-cycle modulation

EBNA3C forms a complex with Cyclin D1 thereby facilitating the G1-S phase transition . Additionally, EBNA2 can affect activities of cell cycle regulators and retards cell cycle progression at G2/M phase. The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. EBV encodes an UL24 homolog termed BXRF1 that should perform this role .

Innate immune response inhibition

EBV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the BGLF4 protein kinase that directly interacts with and inhibits host IRF3. BRLF1 expression also decreases induction of IFN-beta, and reduces expression of IRF3 and IRF7.

Host splicing inhibition

EBV EB2 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

194 entries grouped by protein (browse by keywords)

All proteins are shown (view only 191 complete proteome entries)

Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)

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AN_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
AN_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
AN_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Apoptosis regulator BALF1

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BALF1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BALF1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Secreted protein BARF1 (33 kDa early protein) (p33)

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BARF1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BARF1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BARF1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Protein BDLF2

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BDLF2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BDLF2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BDLF2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Glycoprotein BDLF3


BDLF3_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Uncharacterized protein BFRF2


BFRF2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Uncharacterized protein BHLF1


BHLF1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

G-protein coupled receptor BILF1


BILF1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Glycoprotein BILF2


BILF2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Tegument protein BKRF4

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BKRF4_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BKRF4_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BKRF4_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Uncharacterized protein BLLF2

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BLLF2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BLLF2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BLLF2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Tegument protein BLRF2

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BLRF2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BLRF2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BLRF2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Protein BMRF2

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BMRF2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BMRF2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BMRF2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Protein BNLF2a

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BNL2A_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BNL2A_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BNL2A_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Uncharacterized protein BNLF2b

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BNL2B_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BNL2B_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BNL2B_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Transcriptional activator BRRF1

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BRRF1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BRRF1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BRRF1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Tegument protein BRRF2

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BRRF2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BRRF2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BRRF2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Uncharacterized protein BTRF1

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BTRF1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BTRF1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BTRF1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Trans-activator protein BZLF1 (EB1) (Zebra)

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BZLF1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BZLF1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BZLF1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Cytoplasmic envelopment protein 1

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CEP1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
CEP1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
CEP1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Cytoplasmic envelopment protein 2

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CEP2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
CEP2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
CEP2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Cytoplasmic envelopment protein 3

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CEP3_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
CEP3_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Capsid vertex component 1


CVC1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Capsid vertex component 2

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CVC2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
CVC2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
CVC2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Major DNA-binding protein

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DNBI_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
DNBI_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
DNBI_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

DNA polymerase catalytic subunit (EC 2.7.7.7)

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DPOL_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
DPOL_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
DPOL_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

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DUT_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
DUT_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
DUT_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory subunit)

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EAD_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EAD_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EAD_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)

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EAR_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EAR_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EAR_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)

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EBNA1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)

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EBNA2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) (EBNA-3A) (EBV nuclear antigen 3A)

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EBNA3_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA3_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA3_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) (EBNA-3B) (EBV nuclear antigen 3B)

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EBNA4_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA4_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA4_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) (Epstein-Barr nuclear antigen 5) (EBNA-5) (EBV nuclear antigen 5)

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EBNA5_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA5_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA5_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) (EBNA-3C) (EBV nuclear antigen 3C) (Epstein-Barr nuclear antigen 4B) (EBNA-4B) (EBV nuclear antigen 4B)

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EBNA6_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA6_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA6_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Envelope glycoprotein B (gB)

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GB_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GB_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GB_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Envelope glycoprotein H (gH)

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GH_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GH_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GH_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Envelope glycoprotein L (gL)

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GL_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GL_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GL_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Envelope glycoprotein M (gM)

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GM_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GM_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GM_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Envelope glycoprotein N

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GN_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GN_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GN_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Envelope glycoprotein GP350 (Membrane antigen) (MA)

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GP350_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GP350_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GP350_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Glycoprotein 42 (gp42)

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GP42_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GP42_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GP42_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

DNA replication helicase (EC 3.6.4.-)


HELI_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)

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ICP27_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
ICP27_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
ICP27_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)

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IL10H_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
IL10H_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
IL10H_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Inner tegument protein

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ITP_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
ITP_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
ITP_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Thymidine kinase (EC 2.7.1.21)

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KITH_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
KITH_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
KITH_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)

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KR2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
KR2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
KR2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Uncharacterized LF1 protein

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LF1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LF1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LF1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Protein LF2

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LF2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LF2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LF2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Uncharacterized protein LF3

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LF3_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LF3_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Latent membrane protein 1 (LMP-1) (Protein p63)

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LMP1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVCEpstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)
LMP1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
LMP1_EBVREpstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

Latent membrane protein 2 (Terminal protein)

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LMP2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

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LTP_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LTP_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LTP_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Major capsid protein (MCP)

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MCP_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
MCP_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
MCP_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Major tegument protein (MTP) (Protein p140)

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MTP_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
MTP_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
MTP_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Nuclear egress protein 1

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NEC1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
NEC1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Nuclear egress protein 2


NEC2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Portal protein

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PORTL_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
PORTL_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
PORTL_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

DNA primase (EC 2.7.7.-)


PRIM_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

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RIR1_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
RIR1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
RIR1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

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RIR2_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
RIR2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
RIR2_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Uncharacterized protein RPMS1

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RPMS1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
RPMS1_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Replication and transcription activator (Rta) (Immediate-early protein Rta)

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RTA_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
RTA_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
RTA_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) (Virion structural protein BVRF2)

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SCAF_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
SCAF_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
SCAF_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Small capsomere-interacting protein


SCP_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Tegument protein UL51 homolog

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TEG7_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
TEG7_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
TEG7_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Tripartite terminase subunit 1


TRM1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

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TRM3_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
TRM3_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
TRM3_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

Triplex capsid protein 1


TRX1_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Triplex capsid protein 2


TRX2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Protein UL24 homolog


UL24_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Packaging protein UL32 homolog


UL32_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

TBP-like protein BcRF1


UL87_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Uncharacterized protein BDLF4

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UL92_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
UL92_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Protein BGLF3


UL95_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)


UNG_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Envelope glycoprotein GP340 (Membrane antigen) (MA)


VGP3_EBVP3Epstein-Barr virus (strain P3HR-1) (HHV-4) (Human herpesvirus 4)

Uncharacterized protein BBLF2


YBL2_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Uncharacterized protein EC-RF4


YEC4_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain