Rhadinovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5’ leader sequence of 30-300 bp (not translated), a 3’ untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Kaposi proteins MIR1/K3 and MIR2/K5 are E3 ubiquitin ligase which promote the ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, thereby inhibiting the host adaptive immune response.

Apoptosis modulation

Kaposi sarcoma-associated herpesvirus encodes a viral FLICE inhibitory protein that blocks apoptosis .

Autophagy modulation

The KSHV v-Bcl-2 inhibits host autophagy by interacting with host beclin-1 .

Cell-cycle modulation

KSHV v-cyclin encoded by ORF72, is a cyclin-like protein that shares homology to cellular D-type cyclins. Like human cyclins, v-cyclin interacts with cdk4 and cdk6 to activate these kinases and promote the G1/S phase transition. The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. EBV encodes an UL24 homolog termed ORF20 that should perform this role .

Innate immune response inhibition

Human herpes virus 8 (HHV-8) has developed unique mechanisms to modulate host immune system by incorporating viral homologs to several cellular regulatory genes into its genome. For instance, vIRF-1 is able to bind to both IRF-3 and IRF-7 and efficiently inhibits the formation of transcriptionally competent IRF-3-CBP/p300 complexes .

Splicing inhibition

KSHV ORF57 modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

180 entries grouped by protein (browse by keywords)

All proteins are shown (view only 163 complete proteome entries)

Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)

Select_all Deselect_all  
AN_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
AN_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Apoptosis regulator Bcl-2 homolog


ARBH_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Putative transcription activator BRLF1 homolog (Transcription activator EDRF1)

Select_all Deselect_all  
BRLF1_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
BRLF1_BHV4DBovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

Putative transcription activator BRLF1 homolog

Complement control protein homolog (CCPH)


CCPH_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Surface glycoprotein CD59 homolog


CD59_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Cytoplasmic envelopment protein 1

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CEP1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
CEP1_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Cytoplasmic envelopment protein 2

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CEP2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
CEP2_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Cytoplasmic envelopment protein 3

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CEP3_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
CEP3_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Cyclin homolog (V-cyclin)


CGH2_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Capsid vertex component 1

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CVC1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
CVC1_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Capsid vertex component 2

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CVC2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
CVC2_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Major DNA-binding protein

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DNBI_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
DNBI_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)

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DPOL_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
DPOL_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

DNA polymerase catalytic subunit (EC 2.7.7.7)

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

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DUT_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
DUT_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)

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DYR_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Putative Dihydrofolate reductase (EC 1.5.1.3)

DYR_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
DYR_SHV24Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)
DYR_SHV2CSaimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Envelope glycoprotein B (gB)

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GB_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
GB_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M)

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GCNT3_BHV4Bovine herpesvirus 4 (BoHV-4) (Movar virus)
GCNT3_BHV4DBovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)
GCNT3_BHV4LBovine herpesvirus 4 (strain LVR140) (BoHV-4) (Movar virus)
GCNT3_BHV4VBovine herpesvirus 4 (strain V. test) (BoHV-4) (Movar virus)

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (EC 2.4.1.150) (BORFF3-4) (C2GnT-mucin type) (C2GnT-M)

Probable ganciclovir kinase (EC 2.7.1.-)


GCVK_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Envelope glycoprotein H (gH)

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GH_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
GH_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Envelope glycoprotein L (gL)

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GL_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
GL_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Envelope glycoprotein M (gM)

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GM_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
GM_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Envelope glycoprotein N

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GN_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
GN_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

DNA replication helicase (EC 3.6.4.-)

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HELI_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
HELI_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)


HEPA_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Transcriptional regulator ICP22 homolog (Immediate-early protein)


ICP22_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

mRNA export factor ICP27 homolog (EB2 protein homolog)

Select_all Deselect_all  
ICP27_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
ICP27_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

mRNA export factor ICP27 homolog (52 kDa immediate-early phosphoprotein) (EB2 protein homolog)

Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)

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IL17_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
IL17_SHV2CSaimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Inner tegument protein

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ITP_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
ITP_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Protein K1


K1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein K12


K12_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein K15


K15_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein K4.2


K42_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein K6


K6_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein K7


K7_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein K8.1


K81_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

E3 SUMO-protein ligase K-bZIP (EC 6.3.2.-)


KBZIP_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Thymidine kinase (EC 2.7.1.21)

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KITH_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
KITH_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

Select_all Deselect_all  
LTP_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
LTP_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
LTP_MHV68Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)

Major capsid protein (MCP)

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MCP_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
MCP_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (IE1B protein) (Modulator of immune recognition 1) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)

Select_all Deselect_all  
MIR1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
MIR1_MHV68Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)

E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (MK3) (Modulator of immune recognition 1 homolog) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)

E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) (ORF K5) (RING-type E3 ubiquitin transferase MIR2)


MIR2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Nuclear egress protein 1

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NEC1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
NEC1_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Nuclear egress protein 2

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NEC2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
NEC2_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Protein ORF10


ORF10_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF11


ORF11_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF23


ORF23_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF24


ORF24_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF27


ORF27_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF28


ORF28_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF30


ORF30_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF35


ORF35_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF36 (EC 2.7.-.-)


ORF36_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Complement control protein (KCP)


ORF4_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF45


ORF45_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Tegument protein ORF48


ORF48_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF49


ORF49_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Putative transcription activator ORF50


ORF50_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Tegument protein ORF52


ORF52_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF58


ORF58_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF73


ORF73_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Protein ORF75


ORF75_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

OX-2 membrane glycoprotein homolog (Viral OX2) (vOX2)


OX2V_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

DNA polymerase processivity factor


PAP_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Portal protein

Select_all Deselect_all  
PORTL_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
PORTL_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

DNA primase (EC 2.7.7.-)

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PRIM_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
PRIM_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

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RIR1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
RIR1_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

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RIR2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
RIR2_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)

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SCAF_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
SCAF_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Small capsomere-interacting protein

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SCP_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
SCP_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Saimiri transformation-associated protein (Collagen-like protein) (stpC)

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STP_SHV24Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)
STP_SHV2CSaimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Tegument protein ORF55

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TEG7_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
TEG7_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Gene 55 protein

Protein tio


TIO_ATHV3Ateline herpesvirus 3 (AtHV-3) (Herpesvirus ateles)

Tyrosine-protein kinase-interacting protein (Tip)

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TIP_SHV48Saimiriine herpesvirus 2 (strain 484) (SaHV-2) (Herpesvirus saimiri)

Tyrosine protein kinase-interacting protein (Tip) (TipC484)

TIP_SHV24Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)
TIP_SHV2CSaimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Tripartite terminase subunit 1

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TRM1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
TRM1_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Tripartite terminase subunit 2


TRM2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

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TRM3_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
TRM3_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Triplex capsid protein 1

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TRX1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
TRX1_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Triplex capsid protein 2

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TRX2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
TRX2_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Transforming protein STP


TSTP_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

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TYSY_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
TYSY_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
TYSY_HSVATHerpesvirus ateles

Protein UL24 homolog

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UL24_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
UL24_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Packaging protein UL32 homolog

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UL32_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
UL32_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Packaging protein UL32

Protein ORF66

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UL49_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
UL49_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 66 protein

Protein UL79 homolog

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UL79_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
UL79_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Gene 18 protein

Gene 24 protein


UL87_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 30 protein


UL91_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Protein ORF31

Select_all Deselect_all  
UL92_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
UL92_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Gene 31 protein

Protein UL95 homolog

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UL95_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
UL95_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Gene 34 protein

Gene 35 protein


UL96_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

Select_all Deselect_all  
UNG_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain
UNG_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Protein vCCL3


VCCL3_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

viral cyclin homolog (v-cyclin)


VCYCL_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Viral FLICE protein (vFLIP)


VFLIP_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Uncharacterized gene 5 protein


VG05_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 10 protein


VG10_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 11 protein


VG11_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 12 protein


VG12_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Bcl-2-like gene 16 protein


VG16_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 23 protein


VG23_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 27 protein


VG27_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 28 protein


VG28_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 40 protein


VG40_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 41 protein


VG41_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 45 protein


VG45_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 48 protein


VG48_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 49 protein


VG49_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Gene 51 glycoprotein


VG51_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 52 protein


VG52_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Gene 58 protein


VG58_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Gene 59 protein


VG59_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 71 protein


VG71_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

G-protein coupled receptor homolog ECRF3


VG74_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

viral G-protein coupled receptor (vGPCR) (Protein ORF74)


VGPCR_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Probable E3 ubiquitin-protein ligase IE1 (EC 2.3.2.27) (32.7 kDa immediate early protein IE1) (RING-type E3 ubiquitin transferase IE1)


VIE1_BHV4DBovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

Immediate-early protein IE-G


VIEG_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Viral interleukin-6 homolog (vIL-6)


VIL6_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

VIRF-1


VIRF1_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Viral IRF2-like protein (vIRF-2)


VIRF2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Viral IRF3-like protein (VIRF-3)


VIRF3_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Viral IRF4-like protein (vIRF-4)


VIRF4_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Viral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein II) (vMIP-II) (vMIP-1B)


VMI2_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain

Probable membrane antigen 3 (Tegument protein)


VP03_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Probable membrane antigen 75 (Tegument protein)


VP75_SHV21Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized 9.5 kDa protein in DHFR 3'region (ORF3)


YDH3_SHV2CSaimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

Uncharacterized 9.9 kDa protein in DHFR 3'region (ORF4)


YDH4_SHV2CSaimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)