Lyssavirus (taxid:11286)
VIRION
Enveloped, bullet shaped. 180 nm long and 75 nm wide.
GENOME
Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by alternative initiation.
GENE EXPRESSION
The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.
ENZYMES
- RNA-dependent RNA polymerase [L]
- Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
REPLICATION
CYTOPLASMIC
- Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
- Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
- Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
- The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.
Host-virus interaction
Inhibition of host Interferon induction
Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling 
Rabies phosphoprotein may inhibit IRF-3 phosphorylation
Inhibition of host type I interferon signaling
Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.
Inhibition of T-cell response
Rabies nucleoprotein may act as a superantigen by inhibiting Vbeta T-Cell repertoire
M Lafon, A Galelli
Springer Semin. Immunopathol. 1996; 17: 307?318
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)108 entries grouped by protein
1 entry
Putative uncharacterized protein C
24 entries
Glycoprotein
15 entries
Large structural protein (Protein L) (Replicase) (Transcriptase)
21 entries
Matrix protein (Phosphoprotein M2)
24 entries
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
23 entries
Phosphoprotein (Protein P) (Protein M1)
Australian bat lyssavirus (isolate Bat/AUS/1996) taxid:446561
Duvenhage virus taxid:38767
European bat lyssavirus 1 taxid:57482
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) taxid:453115
European bat lyssavirus 2 taxid:57483
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-07135 |
| Phosphoprotein (Protein P) (Protein M1) | ma-jd-viral-47494 |
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) taxid:453116
Gannoruwa bat lyssavirus taxid:1846259
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-07145 |
| Matrix protein | ma-jd-viral-62212 |
| Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-15326 |
| Phosphoprotein (Protein P) (Protein M1) | ma-jd-viral-47497 |
Ikoma lyssavirus taxid:1167696
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-07138 |
| Matrix protein | ma-jd-viral-62214 |
| Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-15323 |
| Phosphoprotein (Protein P) (Protein M1) | ma-jd-viral-47498 |
Lagos bat virus taxid:38766
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-07144 |
| Matrix protein | ma-jd-viral-62211 |
| Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-15317 |
| Phosphoprotein (Protein P) (Protein M1) | ma-jd-viral-47501 |
Lleida bat lyssavirus taxid:1213198
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-07141 |
| Matrix protein | ma-jd-viral-62218 |
| Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-15319 |
| Phosphoprotein (Protein P) (Protein M1) | ma-jd-viral-47492 |
Lyssavirus bokeloh taxid:1072176
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-07142 |
| Matrix protein | ma-jd-viral-62217 |
| Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-15322 |
| Phosphoprotein (Protein P) (Protein M1) | ma-jd-viral-47496 |
Lyssavirus shimoni taxid:746543
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-07148 |
| Matrix protein | ma-jd-viral-62221 |
| Nucleoprotein (Nucleocapsid protein) | ma-jd-viral-15321 |
| Phosphoprotein (Protein P) (Protein M1) | ma-jd-viral-47493 |
Mokola virus taxid:12538
Rabies virus taxid:11292
| Protein | ModelArchive |
| Glycoprotein | ma-jd-viral-07137 |