Inhibition of host STAT1 by virus

The signal transducer and activator of transcription STAT1 protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT1 in IFN-γ and IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. While IFN-γ induces STAT1 homodimerization, IFN-α/β mainly stimulates heterodimerization of STAT1 and STAT2, both leading to STAT1 activation and nuclear localization.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 e1a P vh1 V C

Many viruses modulate the interferon mediated response by acting on STAT1 using different strategies. The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation. Sendai virus C protein also physically associates with STAT1 and send it to degradation. Vaccinia VH1 phosphatase instead reverses STAT1 activation by interacting with and dephosphorylating STAT1.

Matching UniProtKB/Swiss-Prot entries

110 entries grouped by protein (browse by keywords)

All proteins are shown (view only 78 complete proteome entries)

Protein C'

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C_SENDOSendai virus (strain Ohita) (SeV) reference strain
C_PI3BBovine parainfluenza 3 virus (BPIV-3)

Protein C

C_PI1HBHuman parainfluenza 1 virus (strain C35) (HPIV-1)

Protein C

C_PI1HCHuman parainfluenza 1 virus (strain C39) (HPIV-1)

Protein C

C_PI1HEHuman parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

Protein C

C_PI1HDHuman parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

Protein C

C_PI3H4Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human ...

Protein C (VP18 protein)

C_SEND6Sendai virus (strain 6/94) (SeV)
C_SENDFSendai virus (strain Fushimi) (SeV)
C_SENDASendai virus (strain Hamamatsu) (SeV)
C_SENDHSendai virus (strain Harris) (SeV)
C_SENDNSendai virus (strain Nagoya) (SeV)
C_SENDZSendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

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DUSP_FOWPNFowlpox virus (strain NVSL) (FPV) reference strain
DUSP_MYXVLMyxoma virus (strain Lausanne) (MYXV) reference strain
DUSP_VACCWVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

Dual specificity protein phosphatase H1 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)

DUSP_VAR67Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

Dual specificity protein phosphatase H1 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)

DUSP_RACVIRaccoon poxvirus (RCN)
DUSP_VACCCVaccinia virus (strain Copenhagen) (VACV)

Dual specificity protein phosphatase H1 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)

Early E1A protein (Early E1A 20 kDa protein)

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E1A_ADE12Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain

Early E1A protein (Early E1A 29.5 kDa protein)

E1A_ADE02Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADECCCanine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain ...

Early E1A protein (Early E1A 25 kDa protein)

E1A_ADECGCanine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 ...
E1A_ADECRCanine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 ...
E1A_ADEC2Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)
E1A_ADECTCanine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine ...

Early E1A protein (Early E1A 25 kDa protein)

E1A_ADE07Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE05Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE04Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE40Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

Early E1A protein (Early E1A 27 kDa protein)

E1A_ADE41Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

Early E1A protein (Early E1A 27 kDa protein)

E1A_ADEM1Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

Early E1A 21 kDa protein

E1A_ADES7Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

Phosphoprotein (Protein P) (Protein M1)

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PHOSP_ABLVBAustralian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
PHOSP_EBLV1European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
PHOSP_EBLV2European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
PHOSP_MOKVMokola virus (MOKV) reference strain
PHOSP_RABVPRabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
PHOSP_ARAVAravan virus (ARAV)
PHOSP_ABLVHAustralian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
PHOSP_DUVVDuvenhage virus (DUVV)
PHOSP_IRKVIrkut virus (IRKV)
PHOSP_KHUVKhujand virus (KHUV)
PHOSP_LBVLagos bat virus (LBV)
PHOSP_RABVDRabies virus (strain China/DRV) (RABV)
PHOSP_RABVRRabies virus (strain China/MRV) (RABV)
PHOSP_RABVCRabies virus (strain CVS-11) (RABV)
PHOSP_RABVERabies virus (strain ERA) (RABV)
PHOSP_RABVHRabies virus (strain HEP-Flury) (RABV)
PHOSP_RABVIRabies virus (strain India) (RABV)
PHOSP_RABVNRabies virus (strain Nishigahara RCEH) (RABV)
PHOSP_RABVMRabies virus (strain PM) (RABV)
PHOSP_RABVARabies virus (strain PM1503/AVO1) (RABV)
PHOSP_RABVSRabies virus (strain SAD B19) (RABV)
PHOSP_RABVBRabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
PHOSP_WCBVWest Caucasian bat virus (WCBV)

Genome polyprotein

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POLG_HCVHHepatitis C virus genotype 1a (isolate H) (HCV) reference strain
POLG_HCV1Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCVBKHepatitis C virus genotype 1b (isolate BK) (HCV)
POLG_HCVCOHepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVJ1Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJTHepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVR6Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVJAHepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVTWHepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVJ4Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVH9Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVINHepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ6Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJFHepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJ8Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJPHepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVBBHepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVVAHepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVK3Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZHepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVTRHepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVJKHepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVEDHepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEVHepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVSAHepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCV6AHepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVEUHepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVT5Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVVNHepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVJLHepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVVPHepatitis C virus genotype 6h (isolate VN004) (HCV)
POLG_HCVVOHepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_JAEVJJapanese encephalitis virus (strain Jaoars982)
POLG_JAEV5Japanese encephalitis virus (strain SA(v))
POLG_JAEV1Japanese encephalitis virus (strain SA-14)

Replicase polyprotein 1ab (ORF1ab polyprotein)

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RPOA_PRRSLPorcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
RPOA_PRRSSPorcine reproductive and respiratory syndrome virus (isolate Pig/United ...
RPOA_PRRS1Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
RPOA_PRRSBPorcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV)
RPOA_PRRSRPorcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)

Non-structural protein V

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V_HENDHHendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
V_SV41Simian virus 41 (SV41) reference strain
V_PI4HAHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
V_PI4HBHuman parainfluenza 4b virus (strain 68-333) (HPIV-4b)
V_MEASEMeasles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASAMeasles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose ...
V_MUMPEMumps virus (strain Enders) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPSMumps virus (strain SBL) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMP1Mumps virus (strain SBL-1) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_NIPAVNipah virus
V_PHODVPhocine distemper virus (PDV)
V_RINDKRinderpest virus (strain Kabete O) (RDV)