Nodaviridae

VIRION

Non enveloped virion, about 30 nm in diameter with a T=3 icosahedral symmetry (180 protein subunits).


GENOME

Segmented, bipartite linear, ssRNA(+) genome composed of RNA1=3.1 kb and RNA2=1.4 kb. Each genome segment 5’ end is capped. The 3’end has no poly (A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA1 encodes directly the RNA-dependent RNA polymerase (protein A), and RNA2, the capsid protein. A subgenomic RNA (sgRNA3), 3’ co-linear to RNA1 is also produced and encode proteins B1 and B2.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA-1 is translated to produce the RdRp protein.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the subgenomic RNA-3.
  7. Translation of RNA-2 encoding capsid protein alpha.
  8. Virus assembly in the cytoplasm around genomic RNA1 and RNA2.
  9. Assembled capsid protein alpha is cleaved into capsid protein beta and gamma.
  10. Release of infectious particles (lysis?).

Host-virus interaction

Suppression of RNA silencing

Nodamuravirus protein B2 and Flock house virus protein B2 act as suppressors of RNA silencing .

Matching UniProtKB/Swiss-Prot entries

23 entries grouped by protein (browse by keywords)

All proteins are shown (view only 6 complete proteome entries)

Protein B


B_SJNNVStriped jack nervous necrosis virus (SjNNV) reference strain

Protein B1

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B1_BBVBlack beetle virus (BBV)
B1_FHVFlock house virus (FHV)

Protein B2

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B2_NODAMNodamura virus (strain Mag115) (NoV) reference strain
B2_BBVBlack beetle virus (BBV)
B2_BOOLVBoolarra virus (BoV)
B2_FHVFlock house virus (FHV)

Capsid protein alpha

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CAPSD_NODAMNodamura virus (strain Mag115) (NoV) reference strain
CAPSD_SJNNVStriped jack nervous necrosis virus (SjNNV) reference strain
CAPSD_BBVBlack beetle virus (BBV)
CAPSD_BOOLVBoolarra virus (BoV)
CAPSD_FHVFlock house virus (FHV)
CAPSD_PAVPariacoto virus (PaV)

RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

Select_all Deselect_all  
RDRP_NODAMNodamura virus (strain Mag115) (NoV) reference strain
RDRP_SJNNVStriped jack nervous necrosis virus (SjNNV) reference strain
RDRP_AHNNVAtlantic halibut nervous necrosis virus (AhNNV)
RDRP_BBVBlack beetle virus (BBV)
RDRP_BOOLVBoolarra virus (BoV)
RDRP_FHVFlock house virus (FHV)
RDRP_GGNNVGreasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous ...
RDRP_MRNVMacrobrachium rosenbergii nodavirus (MrNV)

RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase)

RDRP_PAVPariacoto virus (PaV)
RDRP_PRVPieris rapae virus

RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase)