Inhibition of host MAVS by virus

The MAVS protein is required for innate immune defense against viruses. It acts downstream of RIG-I and MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to induction of antiviral cytokines. Alternatively, MAVS can cause apoptosis independent of its function in initiating interferon production. MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane.

RIGI RIGI TRIM25 MAVS STING TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Some viruses selectively inhibit MAVS function. For example, Hepatitis C virus encodes a specific serine protease NS3/4A which cleaves the MAVS transmembrane domain, removes it from the mitochondria thereby preventing interferon production. In a similar way, Hepatitis A encodes for the ABC protein, which localizes to the mitochondria and inhibits MAVS signaling via proteolytic cleavage.

Matching UniProtKB/Swiss-Prot entries

206 entries grouped by protein (browse by keywords)

All proteins are shown (view only 148 complete proteome entries)

Matrix protein M2-2


M22_HMPVCHuman metapneumovirus (strain CAN97-83) (HMPV) reference strain

Non-structural protein 1 (Non-structural protein 1C)

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NS1_BRSVABovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS1_HRSVBHuman respiratory syncytial virus B (strain B1) reference strain
NS1_HRSVAHuman respiratory syncytial virus A (strain A2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSVLHuman respiratory syncytial virus A (strain Long)
NS1_HRSV1Human respiratory syncytial virus B (strain 18537)
NS1_ORSVWOvine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

Protein PB1-F2

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PB1F2_I49A1Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
PB1F2_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB1F2_I34A1Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PB1F2_I80A2Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7) reference strain
PB1F2_I80A8Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2) reference strain
PB1F2_I60A0Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PB1F2_I75A0Influenza A virus (strain A/Beijing/39/1975 H3N2)
PB1F2_I77AAInfluenza A virus (strain A/Brazil/11/1978 H1N1)
PB1F2_I18A0Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus ...
PB1F2_I02A2Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PB1F2_I02A3Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
PB1F2_I01A3Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PB1F2_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB1F2_I01A2Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)
PB1F2_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB1F2_I01A1Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)
PB1F2_I83A5Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PB1F2_I83A6Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
PB1F2_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB1F2_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB1F2_I85A3Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PB1F2_I83A1Influenza A virus (strain A/Chile/1/1983 H1N1)
PB1F2_I96A3Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
PB1F2_I56A1Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PB1F2_I56A2Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PB1F2_I80A6Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PB1F2_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB1F2_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB1F2_I79A7Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PB1F2_I02A1Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PB1F2_I77AFInfluenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
PB1F2_I80ADInfluenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PB1F2_I36A0Influenza A virus (strain A/Henry/1936 H1N1)
PB1F2_I40A0Influenza A virus (strain A/Hickox/1940 H1N1)
PB1F2_I68A4Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
PB1F2_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PB1F2_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB1F2_I83A8Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PB1F2_I80AAInfluenza A virus (strain A/India/6263/1980 H1N1)
PB1F2_I54A2Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PB1F2_I71A1Influenza A virus (strain A/Memphis/1/1971 H3N2)
PB1F2_I72A4Influenza A virus (strain A/Memphis/101/1972 H3N2)
PB1F2_I72A3Influenza A virus (strain A/Memphis/102/1972 H3N2)
PB1F2_I76A6Influenza A virus (strain A/Memphis/110/1976 H3N2)
PB1F2_I78A8Influenza A virus (strain A/Memphis/18/1978 H3N2)
PB1F2_I78A7Influenza A virus (strain A/Memphis/2/1978 H3N2)
PB1F2_I80A4Influenza A virus (strain A/Memphis/4/1980 H3N2)
PB1F2_I00A1Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PB1F2_I73A5Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PB1F2_I06A0Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PB1F2_I01A0Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PB1F2_I02A4Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
PB1F2_I77A4Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PB1F2_I02A7Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
PB1F2_I83A4Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PB1F2_I78ACInfluenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
PB1F2_I68A3Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PB1F2_I66A0Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
PB1F2_I66A1Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PB1F2_I51A0Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PB1F2_I45A0Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PB1F2_I43A0Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PB1F2_I96A2Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PB1F2_I35A3Influenza A virus (strain A/USA:Phila/1935 H1N1)
PB1F2_I07A0Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PB1F2_I77ABInfluenza A virus (strain A/USSR/90/1977 H1N1)
PB1F2_I33A0Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain ...

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

Select_all Deselect_all  
PB2_I49A1Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
PB2_I96A0Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB2_I34A1Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PB2_I80A2Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7) reference strain
PB2_I80A8Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2) reference strain
PB2_I60A0Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PB2_I75A0Influenza A virus (strain A/Beijing/39/1975 H3N2)
PB2_I77AAInfluenza A virus (strain A/Brazil/11/1978 H1N1)

Polymerase basic protein 2

PB2_I18A0Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus ...
PB2_I77AGInfluenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
PB2_I02A0Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PB2_I02A5Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB2_I02A6Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB2_I83A5Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PB2_I59A0Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB2_I03A1Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB2_I85A3Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PB2_I000FInfluenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain ...
PB2_I83A1Influenza A virus (strain A/Chile/1/1983 H1N1)
PB2_I96A3Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

Polymerase basic protein 2

PB2_I56A1Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PB2_I56A2Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PB2_I80A6Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PB2_I00A0Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB2_I69A0Influenza A virus (strain A/England/878/1969 H3N2)
PB2_I86A2Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)
PB2_I73A4Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PB2_I56A3Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
PB2_I47A0Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PB2_I34A0Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PB2_I05A1Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB2_I79A7Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PB2_I84A4Influenza A virus (strain A/Gull/Astrakhan/227/1984 H13N6)
PB2_I77AFInfluenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
PB2_I80ADInfluenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PB2_I36A0Influenza A virus (strain A/Henry/1936 H1N1)

Polymerase basic protein 2

PB2_I40A0Influenza A virus (strain A/Hickox/1940 H1N1)

Polymerase basic protein 2

PB2_I68A4Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
PB2_I97A1Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PB2_I03A0Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB2_I83A8Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PB2_I80AAInfluenza A virus (strain A/India/6263/1980 H1N1)

Polymerase basic protein 2

PB2_I57A0Influenza A virus (strain A/Japan/305/1957 H2N2)
PB2_I79A4Influenza A virus (strain A/Kiev/59/1979 H1N1)
PB2_I93A0Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PB2_I68A5Influenza A virus (strain A/Korea/426/1968 H2N2)
PB2_I57A2Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PB2_I57A1Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PB2_I57A3Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PB2_I54A2Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

Polymerase basic protein 2

PB2_I78A3Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PB2_I71A1Influenza A virus (strain A/Memphis/1/1971 H3N2)
PB2_I72A4Influenza A virus (strain A/Memphis/101/1972 H3N2)
PB2_I72A3Influenza A virus (strain A/Memphis/102/1972 H3N2)
PB2_I76A6Influenza A virus (strain A/Memphis/110/1976 H3N2)
PB2_I78A8Influenza A virus (strain A/Memphis/18/1978 H3N2)
PB2_I78A7Influenza A virus (strain A/Memphis/2/1978 H3N2)
PB2_I80A4Influenza A virus (strain A/Memphis/4/1980 H3N2)
PB2_I88A3Influenza A virus (strain A/Memphis/8/1988 H3N2)
PB2_I00A1Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)

Polymerase basic protein 2

PB2_I68A6Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus ...
PB2_I73A5Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PB2_I70A0Influenza A virus (strain A/Qu/7/1970 H3N2)
PB2_I85A7Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PB2_I06A0Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

Polymerase basic protein 2

PB2_I82A3Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)
PB2_I57A5Influenza A virus (strain A/Singapore/1/1957 H2N2)
PB2_I77A4Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PB2_I30A0Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PB2_I77ACInfluenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
PB2_I61A1Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

Polymerase basic protein 2

PB2_I67A2Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)

Polymerase basic protein 2

PB2_I02A7Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
PB2_I67A0Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PB2_I83A4Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PB2_I68A3Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PB2_I66A0Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
PB2_I66A1Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PB2_I72A2Influenza A virus (strain A/Udorn/307/1972 H3N2)
PB2_I51A0Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

Polymerase basic protein 2

PB2_I45A0Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

Polymerase basic protein 2

PB2_I43A0Influenza A virus (strain A/USA:Iowa/1943 H1N1)

Polymerase basic protein 2

PB2_I96A2Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

Polymerase basic protein 2

PB2_I35A3Influenza A virus (strain A/USA:Phila/1935 H1N1)

Polymerase basic protein 2

PB2_I07A0Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)

Polymerase basic protein 2

PB2_I77ABInfluenza A virus (strain A/USSR/90/1977 H1N1)
PB2_I75A3Influenza A virus (strain A/Victoria/3/1975 H3N2)
PB2_I33A0Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain ...
PB2_I000XInfluenza A virus (strain A/X-31 H3N2)

Genome polyprotein

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POLG_HCVHHepatitis C virus genotype 1a (isolate H) (HCV) reference strain
POLG_HAVHMHuman hepatitis A virus genotype IB (isolate HM175) (HHAV) (Human hepatitis A ... reference strain
POLG_HCV1Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCVBKHepatitis C virus genotype 1b (isolate BK) (HCV)
POLG_HCVCOHepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVJ1Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJTHepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVR6Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVJAHepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVTWHepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVJ4Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVH9Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVINHepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ6Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJFHepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJ8Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJPHepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVBBHepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVVAHepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVK3Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZHepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVTRHepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVJKHepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVEDHepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEVHepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVSAHepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCV6AHepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVEUHepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVT5Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVVNHepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVJLHepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVVPHepatitis C virus genotype 6h (isolate VN004) (HCV)
POLG_HCVVOHepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_GBVBHepatitis GB virus B (GBV-B) (GB virus B)
POLG_HAVGBHuman hepatitis A virus genotype IA (isolate GBM) (HHAV) (Human hepatitis A ...
POLG_HAVH2Human hepatitis A virus genotype IA (isolate H2) (HHAV) (Human hepatitis A ...
POLG_HAVLAHuman hepatitis A virus genotype IA (isolate LA) (HHAV) (Human hepatitis A ...
POLG_HAVMBHuman hepatitis A virus genotype IB (isolate MBB) (HHAV) (Human hepatitis A ...
POLG_HAVCFHuman hepatitis A virus genotype IIA (isolate CF-53) (HHAV) (Human hepatitis A ...
POLG_HAV88Human hepatitis A virus genotype IIB (isolate SLF88) (HHAV) (Human hepatitis A ...
POLG_HAVNOHuman hepatitis A virus genotype IIIA (isolate NOR-21) (HHAV) (Human hepatitis ...
POLG_HAVJ8Human hepatitis A virus genotype IIIB (isolate HAJ85-1) (HHAV) (Human hepatitis ...
POLG_HAVS2Simian hepatitis A virus genotype V (isolate AGM-27) (SHAV) (Simian hepatitis A ...