Autographivirinae

Molecular biology

VIRION

Nonenveloped, head-tail structure. Head is about 60 nm in diameter. The tail is non-contractile, has 6 short subterminal fibers. The capsid is icosahedral with a T=7 symmetry.

GENOME

Linear, dsDNA genome of about 40-42 kb encoding for 55 genes.

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attaches to target cell through its tail fibers.
  2. Injection: viral DNA is injected in host cell periplasm
  3. Transcription and traduction of early genes
  4. Replication of genomic DNA
  5. Transcription and traduction of late genes
  6. Assembly of new virions in host cell cytoplasm
  7. Mature virions are released from the cell by lysis
DB LINKS Nucleotide DB: NCBI
Protein DB: UniProtKB
TAXONOMY Group I: dsDNA viruses
Order: Caudovirales
Family: Podoviridae
Subfamily: Autograpivirinae
Genus: T7-like viruses
SP6-like viruses
phiKMV-like viruses
SPECIES
Type: Enterobacteria phage T7
Enterobacteria phage P22
Bacillus phage phi29
Enterobacteria phage N4
REFERENCE STRAINS Enterobacteria phage T7
Sequence | Genome | Proteome Enterobacteria phage SP6
Sequence | Genome | Proteome Enterobacteria phage phiKMV
Sequence | Genome | Proteome
HOST Bacteria

Epidemiology

GEOGRAPHY Worldwide
TRANSMISSION Passive diffusion through medium
ANTIVIRAL DRUGS

Matching UniProtKB/Swiss-Prot entries

102 entries grouped by protein

All proteins are shown (view only 56 complete proteome entries)

S-adenosyl-L-methionine hydrolase (ADOMetase) (Adenosylmethionine hydrolase) (EC 3.3.1.2)


ADOM_BPT3Enterobacteria phage T3 (Bacteriophage T3)

DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase

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DNLI_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 1A0I 

DNLI_BPT3Enterobacteria phage T3 (Bacteriophage T3)

DNA polymerase (EC 2.7.7.7) (T7 DNA polymerase)

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DPOL_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 1SKR  1SKS  1SKW  1SL0  1SL1  1SL2  1T7P  1T8E  1TK0  1TK5  1TK8  1TKD  1X9M  1X9S  1X9W  1ZYQ  2AJQ 

DPOL_BPT3Enterobacteria phage T3 (Bacteriophage T3)

DNA polymerase (EC 2.7.7.7)

Endo-N-acetylneuraminidase (Endo-N) (EC 3.2.1.129) (Endosialidase)

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ENAN_BPK1EEnterobacteria phage K1E (Bacteriophage K1E)
ENAN_BPK1FEnterobacteria phage K1F (Bacteriophage K1F)

Endo-N-acetylneuraminidase (Endo-N) (EC 3.2.1.129) (Endosialidase) (G102)

pdb 1V0E  1V0F  3GVJ  3GVK  3GVL  3GW6  3JU4 

Probable endopeptidase (EC 3.4.-.-)

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ENPP_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
ENPP_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Endodeoxyribonuclease 1 (EC 3.1.21.2) (Endodeoxyribonuclease I) (Endonuclease)

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ENRN_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 1FZR  1M0D  1M0I  2PFJ  3CAE 

ENRN_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Exodeoxyribonuclease (Exonuclease) (EC 3.1.11.3)

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EXRN_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
EXRN_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Protein kinase (EC 2.7.11.1)


KIPA_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (T7 lysozyme)

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NAAA_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 1ARO  1LBA 

NAAA_BPT3Enterobacteria phage T3 (Bacteriophage T3)

N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (T3 lysozyme)

DNA primase/helicase (EC 2.7.7.-) (EC 3.6.4.12)

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PRIM_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 1CR0  1CR1  1CR2  1CR4  1E0J  1E0K  1NUI  1Q57 

PRIM_BPT3Enterobacteria phage T3 (Bacteriophage T3)

DNA-directed RNA polymerase (EC 2.7.7.6)

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RPOL_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 1ARO  1CEZ  1H38  1MSW  1QLN  1S0V  1S76  1S77  2PI4  2PI5  3E2E  3E3J  4RNP 

RPOL_BPSP6Enterobacteria phage SP6 (Bacteriophage SP6)
RPOL_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 0.3 protein


V03_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 1S7Z  2Y7C 

Gene 0.4 protein


V04_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Gene 0.5 protein


V05_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Protein 0.6B


V06_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Gene 1.1 protein

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V11_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V11_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 1.2 protein

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V12_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V12_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 1.7 protein

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V17_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V17_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 18.7 protein

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V187_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V187_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 19.2 protein

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V192_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V192_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 19.3 protein

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V193_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V193_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 4.2 protein

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V42_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V42_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 4.3 protein

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V43_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V43_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 4.5 protein

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V45_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V45_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 4.7 protein


V47_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Gene 5.5/5.7 fusion protein

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V55_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V55_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 5.5 protein

Gene 5.7 protein


V57_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Gene 5.9 protein

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V59_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
V59_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Major capsid protein 10A

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VC10A_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 2XVR  3IZG 

VC10A_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Minor capsid protein 10B

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VC10B_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
VC10B_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Capsid assembly protein (Scaffolding protein)

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VCAP_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
VCAP_BPT3Enterobacteria phage T3 (Bacteriophage T3)

DNA maturase A (DNA-packaging protein A) (GP18)

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VDMA_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
VDMA_BPT3Enterobacteria phage T3 (Bacteriophage T3)

DNA maturase B (DNA-packaging protein B) (GP19)

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VDMB_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
VDMB_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Helix-destabilizing protein (Single-stranded DNA-binding protein) (SSB protein)

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VHED_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 1JE5 

VHED_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Host specificity protein A


VHSA_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Host specificity protein B

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VHSB_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
VHSB_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Head-to-tail joining protein

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VHTJ_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
VHTJ_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Internal virion protein A


VIVA_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Internal virion protein B


VIVB_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Internal virion protein C


VIVC_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Internal virion protein D


VIVD_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Lysis protein

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VLYS_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
VLYS_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Bacterial RNA polymerase inhibitor

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VRPI_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

pdb 2WNM 

VRPI_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Tail fiber protein

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VTFP_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
VTFP_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Tail tubular protein A


VTTA_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Tail tubular protein B


VTTB_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Uncharacterized gene 1.05 protein


Y105_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 1.4 protein


Y14_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Uncharacterized gene 1.5 protein

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Y15_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
Y15_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 1.6 protein

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Y16_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
Y16_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 1.8 protein

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Y18_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
Y18_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 19.5 protein

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Y195_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
Y195_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 2.8 protein


Y28_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Uncharacterized gene 3.7 protein


Y37_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 3.8 protein


Y38_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Uncharacterized gene 4.1 protein


Y41_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain

Uncharacterized gene 5.1 protein


Y51_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 5.3 protein

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Y53_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
Y53_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 6.3 protein

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Y63_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
Y63_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 6.5 protein

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Y65_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
Y65_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 6.7 protein

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Y67_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
Y67_BPT3Enterobacteria phage T3 (Bacteriophage T3)

Uncharacterized gene 7.7 protein


Y77_BPT7Enterobacteria phage T7 (Bacteriophage T7) reference strain
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