Inhibition of host ISG15 by virus (kw:KW-1095)
The ISG15 protein is a ubiquitin-like modifier induced by interferon, which induces modification and somehow inhibits cellular and viral proteins 
. Like ubiquitin , ISG15 is conjugated to lysines on numerous target proteins through its conserved C-terminal region. This reaction is mediated by specific E1-activating, E2-conjugating, and E3-ligase enzymes, all of which are also IFN-inducible.
Viruses escape from the antiviral activity of ISG15 by using different mechanisms. The influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the severe acute respiratory syndrome coronavirus cleaves ISG15 derivatives.This resluts in inactivation of host antiviral protein MDA-5.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)71 entries grouped by protein
2 entries
RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)
16 entries
Non-structural protein 1 (NS1) (NS1A)
4 entries
RNA-binding protein OPG065 (RNA-binding protein E3) (p25)
21 entries
Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
21 entries
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
7 entries