Evasion of host immunity by viral interleukin-like protein

Interleukins are secreted regulatory proteins that are members of the family of cytokines (immune system molecules) that regulates immune cell activity. Interleukins are produced by immune system cells such as lymphocytes, macrophages and monocytes, and modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

Several viruses encode interleukin-like protein that play a role in immune evasion. They have also been shown to activate cellular signaling cascades that enhance virus replication. EBV, HCMV, EHV and orf virus encode for a homolog of interleukin-10 that is able to downregulate Th1 response. HHV-8 protein K2 shares strong homology with IL6 and was thus also named vIL6. Unlike the human IL6, vIL6 does not require the alpha-subunit receptor IL-R6 for signal transduction. Therefore, vIL6 is able to induce antiapoptotic signaling in cells that do not express IL-6R.

Matching UniProtKB/Swiss-Prot entries

11 entries grouped by protein (browse by keywords)

All proteins are shown (view only 10 complete proteome entries)

Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)

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IL10H_EBVA8Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
IL10H_EBVB9Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
IL10H_EHV2Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

Viral interleukin-10 homolog (vIL-10)

IL10H_HCMVMHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Viral interleukin-10 homolog (cmvIL-10) (vIL-10)

IL10H_EBVGEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
IL10H_EHV2TEquine herpesvirus 2 (strain T400/3) (EHV-2)

Viral interleukin-10 homolog (vIL-10)

IL10H_HCMVAHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Viral interleukin-10 homolog (cmvIL-10) (vIL-10)

Viral interleukin-8 homolog (vIL8)


IL8H_GAHVMGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease ... reference strain

Accessory protein p12I

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P12I_HTL1CHuman T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain
P12I_HTL1AHuman T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)

Viral interleukin-6 homolog (vIL-6)


VIL6_HHV8PHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated ... reference strain