Arenavirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from 60 to 300 nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is about 7,5 kb and S segment 3,5 kb.
Encodes for four proteins.

GENE EXPRESSION

Both segments are ambisense. The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes a messager RNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped, probably by L protein during synthesis.

REPLICATION

CYTOPLASM

  1. Virus attaches to host receptors though GP glycoprotein and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the Z protein under the plasma membrane and buds, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The Z protein plays a role in inhibition of antiviral signaling through RIG-I

Matching UniProtKB/Swiss-Prot entries

87 entries grouped by protein (browse by keywords)

All proteins are shown (view only 66 complete proteome entries)

Pre-glycoprotein polyprotein GP complex

Select_all Deselect_all  
GLYC_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
GLYC_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
GLYC_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
GLYC_ALLVPAllpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
GLYC_BCNVUBear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
GLYC_CHAVBChapare virus (isolate Human/Bolivia/810419/2003)
GLYC_CPXVBCupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
GLYC_GTOVVGuanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
GLYC_IPPYVIppy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
GLYC_JUNINJunin arenavirus (JUNV)
GLYC_LASSGLassa virus (strain GA391) (LASV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_LATVBLatino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
GLYC_LYCVWLymphocytic choriomeningitis virus (strain WE) (LCMV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_MACHUMachupo virus (MACV)
GLYC_MOBVCMobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
GLYC_MOPEIMopeia virus (MOPV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_OLVVAOliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
GLYC_PARVPParana virus (isolate Rat/Paraguay/12056/1965) (PARV)
GLYC_PIARVPichinde arenavirus (PICV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_PIRVVPirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
GLYC_SABVBSabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)
GLYC_TACVTTacaribe virus (strain TRVL 11598) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TACV5Tacaribe virus (strain V5) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TACV7Tacaribe virus (strain V7) (TCRV)

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

GLYC_TAMVUTamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)
GLYC_WWAVUWhitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)

Select_all Deselect_all  
L_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
L_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
L_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
L_ALLVPAllpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
L_BCNVUBear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
L_CHAVBChapare virus (isolate Human/Bolivia/810419/2003)
L_CPXVBCupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
L_GTOVVGuanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
L_IPPYVIppy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
L_JUNINJunin arenavirus (JUNV)
L_LATVBLatino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
L_MACHUMachupo virus (MACV)
L_MOBVCMobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
L_OLVVAOliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
L_PARVPParana virus (isolate Rat/Paraguay/12056/1965) (PARV)
L_PIRVVPirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
L_SABVBSabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)
L_TAMVUTamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)
L_WWAVUWhitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_all Deselect_all  
NCAP_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
NCAP_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
NCAP_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
NCAP_ALLVPAllpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
NCAP_BCNVUBear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
NCAP_CHAVBChapare virus (isolate Human/Bolivia/810419/2003)
NCAP_CPXVBCupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
NCAP_GTOVVGuanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
NCAP_IPPYVIppy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
NCAP_JUNINJunin arenavirus (JUNV)
NCAP_LASSGLassa virus (strain GA391) (LASV)
NCAP_LATVBLatino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
NCAP_LYCVWLymphocytic choriomeningitis virus (strain WE) (LCMV)
NCAP_MACHUMachupo virus (MACV)

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_MOBVCMobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
NCAP_MOPEIMopeia virus (MOPV)
NCAP_OLVVAOliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
NCAP_PARVPParana virus (isolate Rat/Paraguay/12056/1965) (PARV)
NCAP_PIARVPichinde arenavirus (PICV)
NCAP_PIRVVPirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
NCAP_SABVBSabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)
NCAP_TAMVUTamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)
NCAP_WWAVUWhitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)

RING finger protein Z (Protein Z) (Zinc-binding protein)

Select_all Deselect_all  
Z_LASSJLassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
Z_LYCVALymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
Z_TACVFTacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
Z_ALLVPAllpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
Z_BCNVUBear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
Z_CHAVBChapare virus (isolate Human/Bolivia/810419/2003)
Z_CPXVBCupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
Z_GTOVVGuanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
Z_IPPYVIppy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
Z_JUNINJunin arenavirus (JUNV)
Z_LATVBLatino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)
Z_MACHUMachupo virus (MACV)
Z_MOBVCMobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
Z_OLVVAOliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
Z_PARVPParana virus (isolate Rat/Paraguay/12056/1965) (PARV)
Z_PIRVVPirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)
Z_SABVBSabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)
Z_TAMVUTamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)
Z_WWAVUWhitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)