Viral initiation of translation: IRES and DLP
Many viruses have evolved specific ways to initiate viral mRNA translation.The reason is either that the virus shutoff classic host translation, or because the viral RNAs are non-classical, missing a cap or polyadenylation.
Internal Ribosome Entry Site (IRES) are RNA structures that allow cap independent initiation of translation, and are able to initiate translation in the middle of a messenger RNA. Cripavirus IRES also allow the translation initiation on a Alanine or Glutamine tRNA. Downstream Hairpin Loop (DLP) are RNA structures that allow initiation of cap dependent translation in the absence of eIF2 initiation factor, where the initiating methionine tRNA is placed by the DLP structure on the ribosome.