Rubulavirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V protein blocks also the type I and II interferon signaling pathways by interacting with and inhibiting host STAT1 and STAT2 .

Matching UniProtKB/Swiss-Prot entries

78 entries grouped by protein (browse by keywords)

All proteins are shown (view only 30 complete proteome entries)

Fusion glycoprotein F0

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FUS_PI2HTHuman parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
FUS_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain
FUS_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
FUS_SV41Simian virus 41 (SV41) reference strain
FUS_PI2HHuman parainfluenza 2 virus (HPIV-2)
FUS_PI2HGHuman parainfluenza 2 virus (strain Greer) (HPIV-2)
FUS_MUMPRMumps virus (strain RW) (MuV)
FUS_MUMPSMumps virus (strain SBL) (MuV)
FUS_MUMP1Mumps virus (strain SBL-1) (MuV)

Hemagglutinin-neuraminidase (EC 3.2.1.18)

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HN_PI2HTHuman parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
HN_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain
HN_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
HN_SV41Simian virus 41 (SV41) reference strain
HN_PI2HHuman parainfluenza 2 virus (HPIV-2)
HN_PI4HAHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
HN_MUMPRMumps virus (strain RW) (MuV)
HN_MUMP1Mumps virus (strain SBL-1) (MuV)
HN_PIV5DParainfluenza virus 5 (isolate Canine/CPI+) (PIV5) (Simian virus 5)
HN_PIV5CParainfluenza virus 5 (isolate Canine/CPI-) (PIV5) (Simian virus 5)
HN_PIV5LParainfluenza virus 5 (isolate Human/LN) (PIV5) (Simian virus 5)

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_PI2HTHuman parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
L_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain
L_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
L_SV41Simian virus 41 (SV41) reference strain
L_PIV5WParainfluenza virus 5 (strain 21004-WR) (PIV5) (Simian virus 5)

Matrix protein

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MATRX_PI2HTHuman parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

Matrix protein (Membrane protein)

MATRX_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain
MATRX_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

Matrix protein (Membrane protein)

MATRX_SV41Simian virus 41 (SV41) reference strain
MATRX_PI4HAHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
MATRX_PI4HBHuman parainfluenza 4b virus (strain 68-333) (HPIV-4b)
MATRX_LPMVLa Piedad-Michoacan-Mexico virus (LPMV)
MATRX_MUMPSMumps virus (strain SBL) (MuV)
MATRX_MUMP1Mumps virus (strain SBL-1) (MuV)

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

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NCAP_PI2HTHuman parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
NCAP_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain
NCAP_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
NCAP_SV41Simian virus 41 (SV41) reference strain
NCAP_PI4HAHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
NCAP_PI4HBHuman parainfluenza 4b virus (strain 68-333) (HPIV-4b)
NCAP_MUMPJMumps virus (strain Jeryl-Lynn) (MuV)
NCAP_MUMP1Mumps virus (strain SBL-1) (MuV)

Phosphoprotein (Protein P)

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PHOSP_PI2HTHuman parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
PHOSP_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain
PHOSP_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
PHOSP_SV41Simian virus 41 (SV41) reference strain
PHOSP_PI2HHuman parainfluenza 2 virus (HPIV-2)
PHOSP_PI4HAHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
PHOSP_PI4HBHuman parainfluenza 4b virus (strain 68-333) (HPIV-4b)
PHOSP_MUMPEMumps virus (strain Enders) (MuV)
PHOSP_MUMPSMumps virus (strain SBL) (MuV)
PHOSP_MUMP1Mumps virus (strain SBL-1) (MuV)

Small hydrophobic protein

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SH_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain
SH_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
SH_MUMPBMumps virus (strain Belfast) (MuV)
SH_MUMPLMumps virus (strain Bristol 1) (MuV)
SH_MUMP2Mumps virus (strain Edingburgh 2) (MuV)
SH_MUMP4Mumps virus (strain Edingburgh 4) (MuV)
SH_MUMP6Mumps virus (strain Edingburgh 6) (MuV)
SH_MUMPEMumps virus (strain Enders) (MuV)
SH_MUMPJMumps virus (strain Jeryl-Lynn) (MuV)
SH_MUMPKMumps virus (strain Kilham) (MuV)
SH_MUMPAMumps virus (strain Matsuyama) (MuV)
SH_MUMPRMumps virus (strain RW) (MuV)
SH_MUMPSMumps virus (strain SBL) (MuV)
SH_MUMP1Mumps virus (strain SBL-1) (MuV)
SH_MUMPTMumps virus (strain Takahashi) (MuV)
SH_MUMPUMumps virus (strain Urabe vaccine AM9) (MuV)

Non-structural protein V

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V_PI2HTHuman parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain
V_MUMPMMumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_PIV5Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
V_SV41Simian virus 41 (SV41) reference strain
V_PI2HHuman parainfluenza 2 virus (HPIV-2)
V_PI4HAHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
V_PI4HBHuman parainfluenza 4b virus (strain 68-333) (HPIV-4b)
V_MUMPEMumps virus (strain Enders) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPSMumps virus (strain SBL) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMP1Mumps virus (strain SBL-1) (MuV)

Non-structural protein V (Non-structural protein NS1)