Virus/host defense interactions
| Early cell antiviral response:
MDA5-RIGI pathway |
MDA5 inhibition |
| RIG-I inhibition | |
| MAVS inhibition | |
| TRAFs mediated response inhibition | |
| IRF3 inhibition | |
| IRF7 inhibition | |
| IKKE/TBK1/DDX3 complex inhibition |
| Early cell antiviral response: PKR | PKR inhibition |
| PP1 modulation |
| Cross-cell antiviral response:
Interferon signaling |
STAT1 inhibition |
| STAT2 inhibition | |
| IRF9 complex inhibition | |
| TYK2 inhibition | |
| JAK1 inhibition | |
| Interferon receptors inhibition |
| Interferon-induced response: Antiviral state establishment | ISG15 inhibition |
| Tetherin inhibition |
| Host Immunity modulation | Inhibition of soluble complement factors |
| Chemokine regulators | |
| Viral interleukin-like protein | |
| Viral IgG Fc receptors |
| Host transcription modulation | NF-kappa-B inhibition |
| NF-kappa-B activation |
| Autophagy | Host autophagy inhibition |
| Host autophagy activation | |
| Apoptosis modulation | Host apoptosis activation |
| Host apoptosis inhibition | |
| Viral FLIPs | |
| Viral BCL2s | |