Caveolin-mediated endocytosis of virus by host

fusion lysis permeabilisation


Virus internalization by the host cell via caveolae, which are specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane. Caveolins form the structural backbone of caveolae (CAV1/caveolin-1 and CAV2/caveolin-2 ; CAV3/caveolin-3 in muscle cells). Internalization via caveolae is not a constitutive process but only occurs upon cell stimulation. Internalized viruses bound to their host cell receptor are delivered to the early endosome. It has been first thought that bound viruses were first taken to pH-neutral organelles in the cytoplasm called caveosomes and finally delivered to the ER, but this has been refuted in . Caveolae represent a low capacity but highly regulated pathway .

Matching UniProtKB/Swiss-Prot entries

56 entries grouped by protein (browse by keywords)

All proteins are shown (view only 49 complete proteome entries)

Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) (Major surface antigen)

Select_all Deselect_all  
HBSAG_HBVA5Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) ... reference strain
HBSAG_HBVC4Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C) reference strain
HBSAG_HBVCJHepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain
HBSAG_HBVG3Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G) reference strain
HBSAG_HBVA6Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) ...
HBSAG_HBVA1Hepatitis B virus genotype A1 subtype adw2 (isolate Southern-Africa/Cai) (HBV-A)
HBSAG_HBVA7Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)
HBSAG_HBVA2Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)
HBSAG_HBVA4Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)
HBSAG_HBVA3Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)
HBSAG_HBVA9Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)
HBSAG_HBVA8Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)
HBSAG_HBVB4Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) ...
HBSAG_HBVB8Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)
HBSAG_HBVB7Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)
HBSAG_HBVB1Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)
HBSAG_HBVB2Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)
HBSAG_HBVB5Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)
HBSAG_HBVB3Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)
HBSAG_HBVB6Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)
HBSAG_HBVC0Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)
HBSAG_HBVC5Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)
HBSAG_HBVC6Hepatitis B virus genotype C subtype adr (isolate China/NC-1/1988) (HBV-C)

Small envelope protein (S glycoprotein) (S-HBsAg) (SHB) (Small S protein) (Small surface protein)

HBSAG_HBVC8Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)
HBSAG_HBVC1Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)
HBSAG_HBVC3Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)
HBSAG_HBVC2Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)
HBSAG_HBVC9Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)
HBSAG_HBVC7Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)
HBSAG_HBVD2Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)
HBSAG_HBVD7Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)
HBSAG_HBVD1Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) ...
HBSAG_HBVD5Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)
HBSAG_HBVD3Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D)
HBSAG_HBVD6Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)
HBSAG_HBVD4Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)
HBSAG_HBVE2Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)
HBSAG_HBVE4Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
HBSAG_HBVE1Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)
HBSAG_HBVF3Hepatitis B virus genotype F1 (isolate Argentina/sa11/2000) (HBV-F)
HBSAG_HBVF4Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)
HBSAG_HBVF1Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)
HBSAG_HBVF6Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)
HBSAG_HBVH1Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)
HBSAG_HBVH2Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) ...
HBSAG_HBVH3Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) ...

Genome polyprotein

Select_all Deselect_all  
POLG_EC01FEchovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)
POLG_POL3LPoliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

Major capsid protein VP1 (Major structural protein VP1)

Select_all Deselect_all  
VP1_POVMAMurine polyomavirus (strain A2) (MPyV) reference strain
VP1_SV40Simian virus 40 (SV40) reference strain
VP1_POVBKBK polyomavirus (BKPyV) (Human polyomavirus 1)
VP1_POVBABK polyomavirus (strain AS) (BKPyV)
VP1_POVM3Murine polyomavirus (strain 3) (MPyV)
VP1_POVMCMurine polyomavirus (strain Crawford small-plaque) (MPyV)
VP1_POVMKMurine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)
VP1_POVMPMurine polyomavirus (strain P16 small-plaque) (MPyV)

Capsid protein VP1