Viral penetration via permeabilization of host membrane


Some non-enveloped viruses induce local permeabilization of host endosomal membrane to allow virus capsid penetration into the cytoplasm. This is achieved through the interaction between the host membrane and a membrane-penetration protein associated with the capsid.

Viral membrane-penetration protein might require first to be activated, mostly through endosomal acidic pH or receptor binding to display its membrane penetrating activity.

Interestingly it has been shown for rotavirus that the proteins responsible for membrane permeabilization share common mechanisms with enveloped virus fusion proteins .

Prokaryotic dsRNA viruses also have a membrane-interacting component associated to their capsid. Virus entry causes depolarization of the host cell membrane. As for other dsRNA viruses, this membrane-interacting component might thus induce permeabilization of the cell membrane . .

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Links Uniprot Keyword: KW-1173
GO ontology:GO:0099008
Virus Reoviridae
Rotavirus A
Bluetongue virus
Mammalian reoviruses
Nodaviridae
Flock house virus
Parvoviridae
Cystoviridae

Matching UniProtKB/Swiss-Prot entries

132 entries grouped by protein (browse by keywords)

All proteins are shown (view only 65 complete proteome entries)

Capsid protein VP1 (Coat protein VP1)

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CAPSD_AAV2SAdeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

Capsid protein VP1

CAPSD_AADNVAedes albopictus densovirus (isolate Boublik/1994) (AalDNV) reference strain

Capsid protein VP1/VP2 (Coat protein VP1/VP2)

CAPSD_ADVGAleutian mink disease parvovirus (strain G) (ADV) reference strain

Capsid protein VP1

CAPSD_PAVBPBovine parvovirus (isolate pAT153/1986) (BPV) reference strain
CAPSD_PAVHVHuman parvovirus B19 (strain HV) (HPV B19) reference strain

Capsid protein VP1

CAPSD_JDNVPJunonia coenia densovirus (isolate pBRJ/1990) (JcDNV) reference strain

Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)

CAPSD_MUMIPMurine minute virus (strain MVM prototype) (MVM) (Murine minute virus (strain ... reference strain
CAPSD_NODAMNodamura virus (strain Mag115) (NoV) reference strain

Capsid protein alpha

CAPSD_AEDEVAedes densonucleosis virus (strain GKV 002 002) (Aedes densovirus)

Capsid protein VP1/VP2 (Coat protein VP1/VP2)

CAPSD_BOOLVBoolarra virus (BoV)

Capsid protein alpha

CAPSD_PAVCCanine parvovirus type 2 (CPV-2)

Capsid protein VP2 (Coat protein VP2)

CAPSD_PAVCBCanine parvovirus type 2 (isolate Dog/United States/CPV-b/1978) (CPV-2)
CAPSD_PAVCNCanine parvovirus type 2 (isolate Dog/United States/CPV-N/1978) (CPV-2)
CAPSD_PAVC7Canine parvovirus type 2 (strain Dog/United States/780929/-) (CPV-2)
CAPSD_PAVCDCanine parvovirustype 2 (isolate Dog/United States/CPV-d/1988) (CPV-2)
CAPSD_DSDNVDiatraea saccharalis densovirus (DsDNV)

Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)

CAPSD_FPVFeline panleukopenia virus (FPV)
CAPSD_FPV19Feline panleukopenia virus (strain 193) (FPV)
CAPSD_FHVFlock house virus (FHV)

Capsid protein alpha

CAPSD_GMDNVGalleria mellonella densovirus (GmDNV)

Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)

CAPSD_PAVHHHamster parvovirus H1
CAPSD_PAVHUHuman parvovirus B19 (isolate AU) (HPV B19)
CAPSD_MEVAMink enteritis virus (strain Abashiri) (MEV)
CAPSD_MUMIMMurine minute virus (strain MVMi) (MVM) (Murine parvovirus)
CAPSD_PAVPariacoto virus (PaV)

Capsid protein alpha

CAPSD_PAVL3Parvovirus LuIII
CAPSD_PAVP9Porcine parvovirus (strain 90HS) (PPV)
CAPSD_PAVPKPorcine parvovirus (strain Kresse) (PPV)
CAPSD_PAVPNPorcine parvovirus (strain NADL-2) (PPV)

Outer capsid protein mu-1 (Mu1)

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MU1_REOVLReovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
MU1_REOVJReovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)
MU1_REOVDReovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

Non-structural protein NS1


NS1_ADVGAleutian mink disease parvovirus (strain G) (ADV) reference strain

Protein Rep68 (EC 3.6.4.12)


REP68_AAV2SAdeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

Probable non-capsid protein NP1


VNCN_PAVBPBovine parvovirus (isolate pAT153/1986) (BPV) reference strain

Non-capsid protein NS-1 (Non-structural protein NS1)

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VNCS_PAVBPBovine parvovirus (isolate pAT153/1986) (BPV) reference strain
VNCS_PAVCNCanine parvovirus type 2 (isolate Dog/United States/CPV-N/1978) (CPV-2)
VNCS_FPV19Feline panleukopenia virus (strain 193) (FPV)

Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

VNCS_PAVHHHamster parvovirus H1

Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

VNCS_PAVHUHuman parvovirus B19 (isolate AU) (HPV B19)

Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

VNCS_MEVAMink enteritis virus (strain Abashiri) (MEV)

Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

VNCS_MUMIMMurine minute virus (strain MVMi) (MVM) (Murine parvovirus)

Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

VNCS_PAVL3Parvovirus LuIII
VNCS_PAVPKPorcine parvovirus (strain Kresse) (PPV)
VNCS_PAVPNPorcine parvovirus (strain NADL-2) (PPV)

Minor capsid protein VP2 (Minor structural protein VP2)

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VP2_POVJCJC polyomavirus (JCPyV) (JCV) reference strain
VP2_SV40Simian virus 40 (SV40) reference strain
VP2_POVBKBK polyomavirus (BKPyV) (Human polyomavirus 1)
VP2_POVBABK polyomavirus (strain AS) (BKPyV)
VP2_POVS1Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1)

Outer capsid protein VP4 (Hemagglutinin)

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VP4_AQRVCAquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Outer capsid protein VP4

VP4_AQRVGAquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Outer capsid protein VP4

VP4_ROTSHRotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) ... reference strain
VP4_ROTHCRotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C) reference strain
VP4_ROTJ1Rotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N) ... reference strain
VP4_ROTF1Rotavirus A (isolate RVA/Cat/Japan/FRV-1/1986/G3P3[9]) (RV-A) (Rotavirus A ...
VP4_ROTF6Rotavirus A (isolate RVA/Cat/Japan/FRV64/1989/G3P5B[3]) (RV-A)
VP4_ROTB9Rotavirus A (isolate RVA/Cow/Germany/993/1983/G18P[17]) (RV-A)
VP4_ROT18Rotavirus A (isolate RVA/Cow/India/Hg18/2000/G15P[21]) (RV-A)
VP4_ROTBKRotavirus A (isolate RVA/Cow/Japan/KK3/1983/G10P8[11]) (RV-A)
VP4_ROTAPRotavirus A (isolate RVA/Cow/South/Africa/Offal agent/1965/G8P6[1]) (RV-A)
VP4_ROTB6Rotavirus A (isolate RVA/Cow/Thailand/61A/1988/G10P7[5]) (RV-A)
VP4_ROTBARotavirus A (isolate RVA/Cow/Thailand/A44/1988/G10P8[11]) (RV-A)
VP4_ROTB5Rotavirus A (isolate RVA/Cow/Thailand/A5/1988/G8P6[1]) (RV-A)
VP4_ROTBBRotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11 ]) (RV-A)
VP4_ROTBVRotavirus A (isolate RVA/Cow/United States/VMRI/1988/G6P[5]) (RV-A)
VP4_ROTCURotavirus A (isolate RVA/Dog/United States/Cu-1/1982/G3P5A[3]) (RV-A)
VP4_ROTD9Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
VP4_ROTEORotavirus A (isolate RVA/Equine/Japan/HO-5/1980/G3P[X]) (RV-A)
VP4_ROTEHRotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A) ...
VP4_ROTELRotavirus A (isolate RVA/Equine/United Kingdom/L338/1988/G13P12[18]) (RV-A)
VP4_ROTHNRotavirus A (isolate RVA/Human/Australia/McN13/1980/G3P2A[6]) (RV-A)
VP4_ROT41Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus ...
VP4_ROTHURotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)
VP4_ROTHYRotavirus A (isolate RVA/Human/Israel/RO1845/1993/G3P5A[3]) (RV-A)
VP4_ROTHVRotavirus A (isolate RVA/Human/Italy/VA70/1975/G4P1A[8]) (RV-A)
VP4_ROTH1Rotavirus A (isolate RVA/Human/Sweden/1076/1983/G2P2A[6]) (RV-A)
VP4_ROTHQRotavirus A (isolate RVA/Human/Thailand/Mc35/1992/G10P11[14]) (RV-A)
VP4_ROTH7Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
VP4_ROTWIRotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)
VP4_ROTTURotavirus A (isolate RVA/Monkey/United States/TUCH/2003/G3P[24]) (RV-A)
VP4_ROTMERotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)
VP4_ROTMBRotavirus A (isolate RVA/Mouse/United States/Eb/1982/G16P10[16]) (RV-A)
VP4_ROTP3Rotavirus A (isolate RVA/Pig/Australia/CRW-8/1987/G3P9[7]) (RV-A)
VP4_ROT46Rotavirus A (isolate RVA/Pig/Venezuela/A46/1985/G5P13[13]) (RV-A)
VP4_ROTBCRotavirus A (strain RVA/Cow/Canada/C486/1977/G6P6[1]) (RV-A)
VP4_ROTRFRotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
VP4_ROTBURotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
VP4_ROTB4Rotavirus A (strain RVA/Cow/United States/B641/XXXX/G6P7[5]) (RV-A)
VP4_ROTBNRotavirus A (strain RVA/Cow/United States/NCDV-Lincoln/1969/G6P6[1]) (RV-A) ...
VP4_ROTW3Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus ...
VP4_ROTE1Rotavirus A (strain RVA/Equine/United States/FI-14/1980/G3P4[12]) (RV-A) ...
VP4_ROTH5Rotavirus A (strain RVA/Human/Australia/RV-5/1981/G2P1B[4]) (RV-A) (Rotavirus A ...
VP4_ROTH6Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
VP4_ROTH3Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
VP4_ROTHJRotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)
VP4_ROTHKRotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
VP4_ROTHORotavirus A (strain RVA/Human/Japan/MO/1982/G3P1A[8]) (RV-A)
VP4_ROTYORotavirus A (strain RVA/Human/Japan/YO/1977/G3P1A[8]) (RV-A)
VP4_ROTHLRotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
VP4_ROTHTRotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) ...
VP4_ROTADRotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A)
VP4_ROTHDRotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) ...
VP4_ROTHPRotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
VP4_ROTHWRotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
VP4_ROTHMRotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)
VP4_ROTRHRotavirus A (strain RVA/Monkey/United States/RRV/1980/G3P5B[3]) (RV-A)
VP4_ROTPYRotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)
VP4_ROTPGRotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)
VP4_ROTP5Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A ...
VP4_ROTRARotavirus A (strain RVA/Rabbit/United States/ALA/XXXX/G3P11[14]) (RV-A) ...
VP4_ROTS4Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
VP4_ROTS1Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain ...
VP4_ROTSFRotavirus A (strain RVA/SA11-FEM/G3P6[1]) (RV-A) (Simian Agent 11 (strain FEM))
VP4_ROTSSRotavirus A (strain RVA/SA11-SEM/G3P5B[2]) (RV-A) (Simian Agent 11 (strain SEM))
VP4_ROTGARotavirus B (isolate RVB/Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate ...
VP4_ROTGIRotavirus B (isolate RVB/Rat/United States/IDIR/1984/G1P[X]) (RV-B) (Rotavirus ...
VP4_ROTBSRotavirus C (isolate RVC/Cow/Japan/Shintoku/1991/G2P[3]) (RV-C)
VP4_ROTPCRotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C)
VP4_ROTB2Rotavirus X (isolate RVX/Human/Bangladesh/NADRV-B219/2002/GXP[X]) (RV ADRV-N) ...

Outer capsid protein VP5

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VP5_BTV10Bluetongue virus 10 (isolate USA) (BTV 10) reference strain
VP5_AHSV4African horse sickness virus 4 (AHSV-4)
VP5_AHSV6African horse sickness virus 6 (AHSV-6)
VP5_AHSV9African horse sickness virus 9 (AHSV-9)
VP5_BTV1ABluetongue virus 1 (isolate Australia) (BTV 1)
VP5_BTV1SBluetongue virus 1 (isolate South Africa) (BTV 1)
VP5_BTV11Bluetongue virus 11 (isolate USA) (BTV 11)
VP5_BTV13Bluetongue virus 13 (isolate USA) (BTV 13)
VP5_BTV17Bluetongue virus 17 (isolate USA) (BTV 17)
VP5_BTV2ABluetongue virus 2 (isolate USA) (BTV 2)
VP5_BRDBroadhaven virus (BRD)
VP5_EHDV1Epizootic hemorrhagic disease virus 1 (EHDV-1)