Avihepadnavirus

VIRION

Enveloped, spherical. Diameter from about 42nm. Icosahedric capsid with a T=4 symmetry.

GENOME

Partially dsDNA circular genome, about 3.2 kb in size. Encodes for 7 proteins.

GENE EXPRESSION

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Virus attaches to host receptors through major surface antigen and enters the cell by an unknown mechanism.
  2. Relaxed circular DNA (RC-DNA) and capsid are transported via microtubules to the nucleus where DNA is released through the nuclear pore, and repaired to form covalently closed circular DNA (cccDNA).
  3. Transcription by RNA polymerase II of the pregenomic RNA (pgRNA) and subgenomic mRNAs, inducing synthesis of all the viral proteins.
  4. pgRNA is encapsidated, together with the P protein, and reverse-transcribed inside the nucleocapsid in (-)DNA covalently linked to P protein.
  5. (+)DNA synthesis from the (-)DNA template generates new RC-DNA.
  6. Transport to the nucleus of new RC-DNA leads to cccDNA amplification; alternatively, the RC-DNA containing nucleocapsids are enveloped and bud as virions.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by strain (browse by keywords)

4 entries

Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain

Select_all Deselect_all  
CAPSD_DHBVQCapsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBVQProtein P
HBEAG_DHBVQExternal core antigen (HBeAg) (Precore protein)
HBSAG_DHBVQLarge envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

4 entries

Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)

Select_all Deselect_all  
CAPSD_HPBDBCapsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDBProtein P
HBEAG_HPBDBExternal core antigen (HBeAg) (Precore protein)
HBSAG_HPBDBLarge envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

4 entries

Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)

Select_all Deselect_all  
CAPSD_HPBDWCapsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDWProtein P
HBEAG_HPBDWExternal core antigen (HBeAg) (Precore protein)
HBSAG_HPBDWLarge envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

4 entries

Duck hepatitis B virus (strain China) (DHBV)

Select_all Deselect_all  
CAPSD_HPBDCCapsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDCProtein P
HBEAG_HPBDCExternal core antigen (HBeAg) (Precore protein)
HBSAG_HPBDCLarge envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

4 entries

Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)

Select_all Deselect_all  
CAPSD_DHBV3Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBV3Protein P
HBEAG_DHBV3External core antigen (HBeAg) (Precore protein)
HBSAG_DHBV3Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

4 entries

Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)

Select_all Deselect_all  
CAPSD_DHBV1Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBV1Protein P
HBEAG_DHBV1External core antigen (HBeAg) (Precore protein)
HBSAG_DHBV1Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

4 entries

Heron hepatitis B virus (HHBV)

Select_all Deselect_all  
CAPSD_HHBVCapsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HHBVProtein P
HBEAG_HHBVExternal core antigen (HBeAg) (Precore protein)
HBSAG_HHBVLarge envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...