Alphatetraviridae

VIRION

Non enveloped virion, about 40 nm in diameter with a T=4 icosahedral symmetry (240 copies of two proteins derived from the capsid precursor cleavage).

GENOME

Monopartite (Betatetravirus) or bipartite (Omegatetravirus) linear ssRNA(+) genome of about 6.5 kb. The 5’ terminus is capped in Omegatetraviruses but not in Betatetraviruses. The 3’ terminus is not polyadenylated but terminates with a distinctive tRNA-like structure.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA is translated into a polyprotein which is cleaved presumably by a viral protease into replication proteins. Replication produces a subgenomic RNA which encodes for capsid protein.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Genomic RNA is translated to produce replication proteins.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the subgenomic RNA encoding the capsid protein.
  7. Assembly of new virus particles.

Matching UniProtKB/Swiss-Prot entries

5 entries grouped by strain (browse by keywords)

3 entries

Helicoverpa armigera stunt virus (HaSV) reference strain

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CAPSD_HASVCapsid protein (CP) (Coat protein)
P17_HASVProtein p17
RDRP_HASVMethyltransferase/helicase/RNA-directed RNA polymerase (EC 2.1.1.-) (EC ...

2 entries

Nudaurelia capensis beta virus (isolate Pine emperor moth/South Africa) (NbetaV) reference strain

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CAPSD_NCBVSCapsid protein (CP) (Coat protein)
RDRP_NCBVSMethyltransferase/helicase/RNA-directed RNA polymerase (EC 2.1.1.-) (EC ...