H5N1 subtype

VIRION

Molecular biology

Enveloped. Usually rounded but can be filamentous. The virions are 80-120 nm in diameter.

GENOME

Segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP). Contains 8 segments coding for 11 proteins. Segments size range from 890 to 2,341nt. Genome total size is 13.5Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap cleaved from cellular mRNAS by Cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track MP and NS mRNA can be spliced, giving rise to mRNA coding for M2 and NEP proteins PB1-F2 is translated from the +1 ORF of PB1 mRNA

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor through HA protein and is endocytosed in the host cell.
  2. Endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs.
  4. genomic (-)RNA
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.
DB LINKS Nucleotide DB: NCBI
Protein DB: UniProtKB
Virus DB:
IRD Influenza research database
OpenfluDB
TAXONOMY Group V: Negative sense ssRNA viruses
Family: Orthomyxoviridae
Genus: Influenzavirus A
Subtype: H5N1
SPECIES
Main: Influenza A virus A/Goose/Guangdong/1/96 H5N1 (FLUAV)
REFERENCE STRAIN Influenza A virus A/Goose/Guangdong/1/96 (H5N1)
Sequence: RNA1 RNA2 RNA3 RNA4 RNA5 RNA6 RNA7 RNA8
Genome | Proteome
HOST Aquatic birds, Human, Pig, Cat
CELL TROPISM epithelial respiratory cells
CELL RECEPTOR (S) Sialic acids (N-acetylneraminic acid)

Epidemiology

GEOGRAPHY Worldwide, more common in Asia
ASSOCIATED DISEASES Acute febrile digestive tract infection
TRANSMISSION Zoonosis, animal contact
Birds: Fecal-oral route from contaminated water
VACCINE Killed vaccine against annual strains produced but not yet used
ANTIVIRAL DRUGS M2 ion channel inhibitor:
Amantidine, Rimantadine:
Neuraminidase inhibitor:
Zanamivir, Oseltamivir (Tamiflu), Peramivir

Matching UniProtKB/Swiss-Prot entries

160 entries grouped by strain

All proteins are shown (view only 44 complete proteome entries)

11 entries

Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

Select_all Deselect_all  
HEMA_I96A0Hemagglutinin
M1_I96A0Matrix protein 1 (M1)
M2_I96A0Matrix protein 2 (Proton channel protein M2)
NCAP_I96A0Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I96A0Nuclear export protein (NEP) (Non structural protein 2) (NS2)
NRAM_I96A0Neuraminidase (EC 3.2.1.18)
NS1_I96A0Non-structural protein 1 (NS1) (NS1A)
PA_I96A0Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)

pdb 3EBJ  3HW3  3HW4  3HW5  3HW6 

PB1F2_I96A0Protein PB1-F2
PB2_I96A0Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I96A0RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

11 entries

Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)

Select_all Deselect_all  
HEMA_I59A0Hemagglutinin
M1_I59A0Matrix protein 1 (M1)
M2_I59A0Matrix protein 2 (Proton channel protein M2)
NCAP_I59A0Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I59A0Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I59A0Neuraminidase (EC 3.2.1.18)
NS1_I59A0Non-structural protein 1 (NS1) (NS1A)
PA_I59A0Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I59A0Protein PB1-F2
PB2_I59A0Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I59A0RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

11 entries

Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)

Select_all Deselect_all  
HEMA_I00A0Hemagglutinin
M1_I00A0Matrix protein 1 (M1)
M2_I00A0Matrix protein 2 (Proton channel protein M2)
NCAP_I00A0Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I00A0Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I00A0Neuraminidase (EC 3.2.1.18)
NS1_I00A0Non-structural protein 1 (NS1) (NS1A)
PA_I00A0Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I00A0Protein PB1-F2
PB2_I00A0Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I00A0RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

11 entries

Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

Select_all Deselect_all  
HEMA_I97A1Hemagglutinin
M1_I97A1Matrix protein 1 (M1)
M2_I97A1Matrix protein 2 (Proton channel protein M2)

pdb 2KAD  2KQT  3C9J  3LBW 

NCAP_I97A1Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I97A1Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I97A1Neuraminidase (EC 3.2.1.18)
NS1_I97A1Non-structural protein 1 (NS1) (NS1A)
PA_I97A1Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I97A1Protein PB1-F2
PB2_I97A1Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I97A1RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

pdb 3CM8 

10 entries

Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

Select_all Deselect_all  
M1_I02A6Matrix protein 1 (M1)
M2_I02A6Matrix protein 2 (Proton channel protein M2)
NCAP_I02A6Nucleoprotein
NEP_I02A6Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I02A6Neuraminidase (EC 3.2.1.18)
NS1_I02A6Non-structural protein 1 (NS1) (NS1A)
PA_I02A6Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I02A6Protein PB1-F2
PB2_I02A6Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I02A6RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

9 entries

Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)

Select_all Deselect_all  
M1_I02A2Matrix protein 1 (M1)
M2_I02A2Matrix protein 2 (Proton channel protein M2)
NCAP_I02A2Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I02A2Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I02A2Neuraminidase (EC 3.2.1.18)
NS1_I02A2Non-structural protein 1 (NS1) (NS1A)
PA_I02A2Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I02A2Protein PB1-F2
RDRP_I02A2RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

9 entries

Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)

Select_all Deselect_all  
M1_I01A3Matrix protein 1 (M1)
M2_I01A3Matrix protein 2 (Proton channel protein M2)
NCAP_I01A3Nucleoprotein
NEP_I01A3Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I01A3Neuraminidase (EC 3.2.1.18)
NS1_I01A3Non-structural protein 1 (NS1) (NS1A)
PA_I01A3Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I01A3Protein PB1-F2
RDRP_I01A3RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

9 entries

Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)

Select_all Deselect_all  
M1_I02A5Matrix protein 1 (M1)
M2_I02A5Matrix protein 2 (Proton channel protein M2)
NCAP_I02A5Nucleoprotein
NEP_I02A5Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I02A5Neuraminidase (EC 3.2.1.18)
NS1_I02A5Non-structural protein 1 (NS1) (NS1A)
PA_I02A5Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I02A5Protein PB1-F2
PB2_I02A5Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

9 entries

Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)

Select_all Deselect_all  
M1_I03A1Matrix protein 1 (M1)
M2_I03A1Matrix protein 2 (Proton channel protein M2)
NCAP_I03A1Nucleoprotein
NEP_I03A1Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I03A1Neuraminidase (EC 3.2.1.18)
NS1_I03A1Non-structural protein 1 (NS1) (NS1A)
PB1F2_I03A1Protein PB1-F2
PB2_I03A1Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I03A1RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

9 entries

Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)

Select_all Deselect_all  
M1_I01A0Matrix protein 1 (M1)
M2_I01A0Matrix protein 2 (Proton channel protein M2)
NCAP_I01A0Nucleoprotein
NEP_I01A0Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I01A0Neuraminidase (EC 3.2.1.18)
NS1_I01A0Non-structural protein 1 (NS1) (NS1A)
PA_I01A0Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I01A0Protein PB1-F2
RDRP_I01A0RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

9 entries

Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

Select_all Deselect_all  
M1_I02A4Matrix protein 1 (M1)
M2_I02A4Matrix protein 2 (Proton channel protein M2)
NCAP_I02A4Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I02A4Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I02A4Neuraminidase (EC 3.2.1.18)
NS1_I02A4Non-structural protein 1 (NS1) (NS1A)
PA_I02A4Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I02A4Protein PB1-F2
RDRP_I02A4RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

8 entries

Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)

Select_all Deselect_all  
HEMA_I97A0Hemagglutinin
M1_I97A0Matrix protein 1 (M1)
M2_I97A0Matrix protein 2 (Proton channel protein M2)
NEP_I97A0Nuclear export protein (NEP) (Non structural protein 2) (NS2)
NRAM_I97A0Neuraminidase (EC 3.2.1.18)
NS1_I97A0Non-structural protein 1 (NS1) (NS1A)
PA_I97A0Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
RDRP_I97A0RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

8 entries

Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)

Select_all Deselect_all  
M1_I02A3Matrix protein 1 (M1)
M2_I02A3Matrix protein 2 (Proton channel protein M2)
NCAP_I02A3Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I02A3Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I02A3Neuraminidase (EC 3.2.1.18)
NS1_I02A3Non-structural protein 1 (NS1) (NS1A)
PB1F2_I02A3Protein PB1-F2
RDRP_I02A3RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

8 entries

Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)

Select_all Deselect_all  
M1_I03A0Matrix protein 1 (M1)
M2_I03A0Matrix protein 2 (Proton channel protein M2)
NCAP_I03A0Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I03A0Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NS1_I03A0Non-structural protein 1 (NS1) (NS1A)
PB1F2_I03A0Protein PB1-F2
PB2_I03A0Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I03A0RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

7 entries

Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)

Select_all Deselect_all  
M1_I01A2Matrix protein 1 (M1)
M2_I01A2Matrix protein 2 (Proton channel protein M2)
NCAP_I01A2Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I01A2Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NRAM_I01A2Neuraminidase (EC 3.2.1.18)
NS1_I01A2Non-structural protein 1 (NS1) (NS1A)
PB1F2_I01A2Protein PB1-F2

6 entries

Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)

Select_all Deselect_all  
M1_I01A1Matrix protein 1 (M1)
M2_I01A1Matrix protein 2 (Proton channel protein M2)
NCAP_I01A1Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I01A1Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NS1_I01A1Non-structural protein 1 (NS1) (NS1A)
PB1F2_I01A1Protein PB1-F2

6 entries

Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)

Select_all Deselect_all  
M1_I05A1Matrix protein 1 (M1)
M2_I05A1Matrix protein 2 (Proton channel protein M2)
PA_I05A1Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I05A1Protein PB1-F2
PB2_I05A1Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I05A1RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...

5 entries

Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)

Select_all Deselect_all  
NCAP_I02A1Nucleoprotein (Nucleocapsid protein) (Protein N)
NEP_I02A1Nuclear export protein (NEP) (Non-structural protein 2) (NS2)
NS1_I02A1Non-structural protein 1 (NS1) (NS1A)
PA_I02A1Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB1F2_I02A1Protein PB1-F2

4 entries

Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)

Select_all Deselect_all  
NCAP_I02A7Nucleoprotein
PB1F2_I02A7Protein PB1-F2
PB2_I02A7Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_I02A7RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...
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