Cucumovirus

VIRION

Non-enveloped, spherical virion about 29nm in diameter with T=3 icosahedral symmetry, composed of 180 coat proteins: 12 pentamers and 20 hexamers.

GENOME

Segmented, tripartite linear ssRNA(+) genome composed of RNA1, RNA2, RNA3. Each genomic segment has a 3’ tRNA-like structure and a 5’cap.

GENE EXPRESSION

Genomic RNA serves as messenger RNAs. RNA1 and RNA2 encode respectively proteins 1a and 2a, both involved in genome replication and internal transcription of sgRNA4 from the minus-strand copy of RNA3. RNA3 and sgRNA4 are translated respectively into movement and capsid proteins. ORF2b encodes a viral suppressor of RNA silencing and is expressed probably as a subgenomic RNA (sgRNA4A).

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Expression of protein 1a and 2a to produce replication proteins.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER (spherules). A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA4 is translated producing capsid proteins.
  7. Assembly of new virus particles.
  8. Viral movement protein triggers the formation of tubular structures that mediate virion cell-to-cell transfer via a tubule-guided mechanism.

Host-virus interaction

Suppression of RNA silencing

Cucumovirus protein 2b acts as a suppressor of RNA silencing .

Matching UniProtKB/Swiss-Prot entries

74 entries grouped by strain (browse by keywords)

All proteins are shown (view only 15 complete proteome entries)

5 entries

Cucumber mosaic virus (strain FNY) (CMV) reference strain

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1A_CMVFNReplication protein 1a
2B_CMVFNSuppressor of silencing 2b (Protein 2b)
CAPSD_CMVFNCapsid protein (CP) (Coat protein)
MVP_CMVFNMovement protein (MP) (Protein 3A)
RDRP_CMVFNRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

5 entries

Cucumber mosaic virus (strain Q) (CMV)

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1A_CMVQReplication protein 1a
2B_CMVQSuppressor of silencing 2b (Protein 2b)
CAPSD_CMVQCapsid protein (CP) (Coat protein)
MVP_CMVQMovement protein (MP) (Protein 3A)
RDRP_CMVQRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

5 entries

Tomato aspermy virus (TAV)

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1A_TAVReplication protein 1a
2B_TAVSuppressor of silencing 2b (Protein 2b)
CAPSD_TAVCapsid protein (CP) (Coat protein)
MVP_TAVMovement protein (MP) (Protein 3A)
RDRP_TAVRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

4 entries

Cucumber mosaic virus (strain Ixora) (CMV)

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1A_CMVIXReplication protein 1a
CAPSD_CMVIXCapsid protein (CP) (Coat protein)
MVP_CMVIXMovement protein (MP) (Protein 3A)
RDRP_CMVIXRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

4 entries

Cucumber mosaic virus (strain NT9) (CMV)

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1A_CMVNTReplication protein 1a
CAPSD_CMVNTCapsid protein (CP) (Coat protein)
MVP_CMVNTMovement protein (MP) (Protein 3A)
RDRP_CMVNTRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

4 entries

Cucumber mosaic virus (strain Y) (CMV)

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1A_CMVYReplication protein 1a
CAPSD_CMVYCapsid protein (CP) (Coat protein)
MVP_CMVYMovement protein (MP) (Protein 3A)
RDRP_CMVYRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

4 entries

Peanut stunt virus (strain J) (PSV)

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1A_PSVJReplication protein 1a
CAPSD_PSVJCapsid protein (CP) (Coat protein)
MVP_PSVJMovement protein (MP) (Protein 3A)
RDRP_PSVJRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

3 entries

Cucumber mosaic virus (strain As) (CMV)

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CAPSD_CMVASCapsid protein (CP) (Coat protein)
MVP_CMVASMovement protein (MP) (Protein 3A)
RDRP_CMVASRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

3 entries

Cucumber mosaic virus (strain Iizuka) (CMV)

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1A_CMVIIReplication protein 1a
CAPSD_CMVIICapsid protein (CP) (Coat protein)
RDRP_CMVIIRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

3 entries

Cucumber mosaic virus (strain Kor) (CMV)

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CAPSD_CMVKOCapsid protein (CP) (Coat protein)
MVP_CMVKOMovement protein (MP) (Protein 3A)
RDRP_CMVKORNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

3 entries

Cucumber mosaic virus (strain O) (CMV)

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1A_CMVOReplication protein 1a
CAPSD_CMVOCapsid protein (CP) (Coat protein)
MVP_CMVOMovement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain C7-2) (CMV)

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CAPSD_CMVC7Capsid protein (CP) (Coat protein)
MVP_CMVC7Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain CS) (CMV)

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CAPSD_CMVCSCapsid protein (CP) (Coat protein)
MVP_CMVCSMovement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain FT) (CMV)

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CAPSD_CMVFTCapsid protein (CP) (Coat protein)
MVP_CMVFTMovement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain Kin) (CMV)

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CAPSD_CMVKICapsid protein (CP) (Coat protein)
MVP_CMVKIMovement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain M) (CMV)

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CAPSD_CMVMCapsid protein (CP) (Coat protein)
MVP_CMVMMovement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain M48) (CMV)

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CAPSD_CMVM4Capsid protein (CP) (Coat protein)
MVP_CMVM4Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain N) (CMV)

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CAPSD_CMVNCapsid protein (CP) (Coat protein)
MVP_CMVNMovement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain Pepo) (CMV)

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CAPSD_CMVPECapsid protein (CP) (Coat protein)
MVP_CMVPEMovement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain S) (CMV)

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CAPSD_CMVSCapsid protein (CP) (Coat protein)
MVP_CMVSMovement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain Trk7) (CMV)

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CAPSD_CMVTRCapsid protein (CP) (Coat protein)
MVP_CMVTRMovement protein (MP) (Protein 3A)

1 entry

Cucumber mosaic virus (strain B) (CMV)


RDRP_CMVBRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

1 entry

Cucumber mosaic virus (strain Banana) (CMV)


CAPSD_CMVBACapsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain C) (CMV)


CAPSD_CMVCCapsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain DKRD) (CMV)


CAPSD_CMVDKCapsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain E5) (CMV)


CAPSD_CMVE5Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain FC) (CMV)


CAPSD_CMVFCCapsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain I17F) (CMV)


CAPSD_CMVI1Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain K) (CMV)


RDRP_CMVKRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

1 entry

Cucumber mosaic virus (strain MB-8) (CMV)


RDRP_CMVMBRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

1 entry

Cucumber mosaic virus (strain P6) (CMV)


CAPSD_CMVP6Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain WL) (CMV)


CAPSD_CMVWLCapsid protein (CP) (Coat protein)