Anulavirus

VIRION

Quasi-spherical virion about 25-35 nm in diameter probably with T=3 icosahedral symmetry.

GENOME

Segmented, tripartite linear ssRNA(+) genome composed of RNA1, RNA2, RNA3. Each genomic segment has a 5’cap.

GENE EXPRESSION

Genomic RNA serves as messenger RNAs. RNA1 and RNA2 encode respectively proteins 1a and 2a, both involved in genome replication and internal transcription of sgRNA4 from the minus-strand copy of RNA3. RNA3 and sgRNA4 are translated respectively into movement and capsid proteins.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Expression of protein 1a and 2a to produce replication proteins.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER (spherules). A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA4 is translated producing capsid proteins.
  7. Assembly of new virus particles.
  8. Viral movement protein triggers the formation of tubular structures that mediate virion cell-to-cell transfer via a tubule-guided mechanism.

Matching UniProtKB/Swiss-Prot entries

4 entries grouped by strain (browse by keywords)

4 entries

Pelargonium zonate spot virus (isolate Tomato/Italy/1982) (PZSV) (Pelargonium zonate spot virus (isolate Tomato)) reference strain

Select_all Deselect_all  
1A_PZSVTReplication protein 1a
CAPSD_PZSVTCapsid protein (CP) (Coat protein)
MVP_PZSVTMovement protein (MP) (Protein 3A)
RDRP_PZSVTRNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)