Corticoviridae

VIRION

Icosahedral T=21 capsid 56 nm in diameter, composed of 1200 P1 (spike) and 60 P2 (capsid) proteins. The pentameric receptor-binding spikes are protruding from the 12 fivefold axes. The capsid encloses an internal lipid core containing the structural proteins P3 to P9.

GENOME

Circular, supercoiled dsDNA genome of about 10 kb encoding for 21 proteins. Displays a very high number of negative supercoils.

GENE EXPRESSION

The genome is organized in three operons.

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attach to target cell
  2. Injection: viral DNA is injected in host cell cytoplasm
  3. Transcription and traduction of early genes
  4. Replication of genomic DNA via a rolling-circle mechanism
  5. Transcription and traduction of late genes
  6. Capsid proteins polymerize around a lipoprotein vesicle translocated in the cytoplasm by virion assembly factors.
  7. Genomic DNA is packaged in new virions
  8. Mature virions are released from the cell by lysis

Matching UniProtKB/Swiss-Prot entries

21 entries grouped by strain (browse by keywords)

21 entries

Pseudoalteromonas phage PM2 (Bacteriophage PM2) reference strain

Select_all Deselect_all  
CAPSD_BPPM2Major capsid protein P2 (Protein II)
GPA_BPPM2Uncharacterized protein Gp-a
GPB_BPPM2Uncharacterized protein Gp-b*
GPC_BPPM2Uncharacterized protein Gp-c
GPD_BPPM2Uncharacterized protein Gp-d
GPE_BPPM2Uncharacterized protein Gp-e
GPH_BPPM2Uncharacterized protein Gp-h
GPJ_BPPM2Uncharacterized protein Gp-j
GPK_BPPM2Uncharacterized protein Gp-k
GPL_BPPM2Uncharacterized protein Gp-l
P12_BPPM2Probable replication protein P12 (EC 3.1.-.-) (Protein XII)
P13_BPPM2Transcription factor P13 (Protein XIII)
P14_BPPM2Uncharacterized protein P14 (Protein XIV)
P3_BPPM2Protein P3 (Protein III)
P4_BPPM2Protein P4 (Protein IV)
P5_BPPM2Protein P5 (Protein V)
P6_BPPM2Protein P6 (Protein VI)
P7_BPPM2Protein P7 (Protein VII)
P8_BPPM2Protein P8 (Protein VIII)
P9_BPPM2Protein P9 (Protein IX)
SPIKE_BPPM2Spike protein P1 (Protein I)