Polydnaviridae

VIRION

Enveloped, prolate ellipsoid form (ichnovirus) and cylindrical (bracovirus). Depending on the species, a virion contains one or several nucleocapsids.

GENOME

Segmented, circular supercoiled dsDNAs ranging from 2.0-31kb. Each virion contains multiple copies of the genome.

GENE EXPRESSION

REPLICATION

NUCLEAR

a) replicative: occurs in the calyx cells of the ovary.

  1. Excision and circularization of viral DNA in the ovary cells.
  2. Viral DNA synthesis.
  3. Appearance of viral envelopes and nucleocapsids in the nucleus.
  4. Mature virions are released into the lumen of the oviduct probably by lysis (brachovirus) or budding through the cell membrane (ichnovirus).

b) vegetative: occurs in all non-reproductive cells.

The viral genome is transmitted in proviral linear form integrated in the wasp’s chromosomes. The virus DNA is replicated, just like any other part of the wasp’s genome.

Host-virus interaction

Apoptosis modulation

PTP-H2 triggers mitochondrial membrane depolarization and caspase-dependent apoptosis suggesting that apoptosis is induced through a mitochondria-dependent death pathway.

NF-kappa-B modulation

Polydnavirus Ank proteins bind NF-kappa-B homodimers and inhibit processing of relish/NF-kappa-B p110 subunit .

Innate immune response inhibition

Microplitis demolitor cracovirus PTP-H2 and PTP-H3 are functional tyrosine phosphatases whose expression inhibit phagocytosis . Another protein, Glc1.8 is also involved in suppression of the insect cellular immune response .

Matching UniProtKB/Swiss-Prot entries

53 entries grouped by strain (browse by keywords)

All proteins are shown (view only 52 complete proteome entries)

52 entries

Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

Select_all Deselect_all  
EG04A_MDBVWProbable protease inhibitor Egf0.4a
EG04B_MDBVWProbable protease inhibitor Egf0.4b
EG10_MDBVWProtease inhibitor Egf1.0
EG15A_MDBVWProtease inhibitor Egf1.5a
EG15B_MDBVWProtease inhibitor Egf1.5b
GL18A_MDBVWMucin-like protein Glc1.8a
GL18B_MDBVWMucin-like protein Glc1.8b (Glc1.8b)
IKBC1_MDBVWI-Kappa-B like protein C1
IKBC2_MDBVWI-Kappa-B like protein C2
IKBF1_MDBVWI-Kappa-B like protein F1
IKBF2_MDBVWI-Kappa-B like protein F2
IKBG1_MDBVWI-Kappa-B like protein G1
IKBG2_MDBVWI-Kappa-B like protein G2
IKBH1_MDBVWI-Kappa-B like protein H1
IKBI1_MDBVWI-Kappa-B like protein I1
IKBJ1_MDBVWI-Kappa-B like protein J1
IKBN1_MDBVWI-Kappa-B like protein N1
IKBN2_MDBVWI-kappa-B like protein N2
IKBN3_MDBVWI-Kappa-B like protein N3
PTPD1_MDBVWTruncated tyrosine phosphatase D1 (PTP-D1)
PTPH1_MDBVWTyrosine phosphatase-like protein H1 (PTP-H1)
PTPH2_MDBVWTyrosine phosphatase H2 (PTP-H2) (EC 3.1.3.48)
PTPH3_MDBVWTyrosine phosphatase H3 (PTP-H3) (EC 3.1.3.48)
PTPH4_MDBVWProbable tyrosine phosphatase protein H4 (PTP-H4) (EC 3.1.3.48)
PTPH5_MDBVWTyrosine phosphatase-like protein H5 (PTP-H5)
PTPJ1_MDBVWTyrosine phosphatase-like protein J1 (PTP-J1)
PTPJ2_MDBVWProbable tyrosine phosphatase protein J2 (PTP-J2) (EC 3.1.3.48)
PTPJ3_MDBVWTyrosine phosphatase-like protein J3 (PTP-J3)
PTPJ4_MDBVWProbable tyrosine phosphatase protein J4 (PTP-J4) (EC 3.1.3.48)
PTPN1_MDBVWProbable tyrosine phosphatase protein N1 (PTP-N1) (EC 3.1.3.48)
PTPN2_MDBVWTyrosine phosphatase-like protein N2 (PTP-N2)
PTPN3_MDBVWTyrosine phosphatase-like protein N3 (PTP-N3)
YA1_MDBVWUncharacterized protein A1
YA2_MDBVWUncharacterized protein A2
YB1_MDBVWPutative BEN domain-containing protein B1
YC3_MDBVWUncharacterized protein C3
YD2_MDBVWUncharacterized protein D2
YD3_MDBVWUncharacterized protein D3
YE1_MDBVWUncharacterized protein E1
YE2_MDBVWUncharacterized protein E2
YF1_MDBVWUncharacterized protein F1
YG1_MDBVWUncharacterized protein G1
YG2_MDBVWUncharacterized protein G2
YI2_MDBVWUncharacterized protein I2
YK1_MDBVWUncharacterized protein K1
YL1_MDBVWUncharacterized protein L1
YM1_MDBVWUncharacterized protein M1
YM2_MDBVWUncharacterized protein M2
YM3_MDBVWUncharacterized protein M3
YM4_MDBVWUncharacterized protein M4
YM5_MDBVWUncharacterized protein M5
YN1_MDBVWUncharacterized protein N1

1 entry

Campoletis sonorensis ichnovirus (CsIV)


REEP_CSIVRepeat element protein