Leviviridae

VIRION

Non-enveloped, spherical virion about 26 nm in diameter with T=3 icosahedral symmetry composed of 180 CP proteins and a single A protein.

GENOME

Monopartite, linear, ssRNA(+) genome about 4 kb in size. The 5’ end is capped. Encodes 4 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Encodes 4 ORFs. Cp protein represses replicase translation by binding a RNA hairpin at the start site of this gene.
Lysis protein is expressed by suppression of termination of an UGA nonsense codon in allolevivirus genus.

REPLICATION

  1. Adsorption to F pili of target cells induces cleavage and release of A protein.
  2. Genomic RNA enters the bacterium.
  3. Viral proteins are translated.
  4. Viral replicase assembles with host proteins (ribosomal protein s1, translation elongation factor EF-Tu and EF-Ts) to form the active RNA polymerase.
  5. Replication of genomic RNA into a minus strand, which serves as template to produce new positive strand genomes.
  6. Late in infection CP protein bind to a RNA hairpin on the genome, and new virus particles are assembled in the cytoplasm.
  7. Release by cell lysis.

Matching UniProtKB/Swiss-Prot entries

29 entries grouped by strain (browse by keywords)

All proteins are shown (view only 20 complete proteome entries)

4 entries

Enterobacteria phage MS2 (Bacteriophage MS2) reference strain

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COAT_BPMS2Coat protein
RDRP_BPMS2RNA-directed RNA polymerase beta chain (EC 2.7.7.48) (RNA replicase beta chain)
VASS_BPMS2Assembly protein (Maturation protein) (A protein)
VLYS_BPMS2Lysis protein (L protein)

4 entries

Enterobacteria phage MX1 (Bacteriophage MX1) reference strain

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CAPSD_BPMX1Capsid protein (CP) (Coat protein)
RDRP_BPMX1RNA-directed RNA polymerase beta chain (EC 2.7.7.48) (RNA replicase beta chain)
VA1_BPMX1Readthrough protein A1
VASS_BPMX1Maturation protein (A2)

4 entries

Enterobacteria phage GA (Bacteriophage GA)

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COAT_BPGACoat protein
RDRP_BPGARNA-directed RNA polymerase beta chain (EC 2.7.7.48) (RNA replicase beta chain)
VASS_BPGAAssembly protein (Maturation protein) (A protein)
VLYS_BPGALysis protein

4 entries

Enterobacteria phage SP (Bacteriophage SP)

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COAT_BPSPCoat protein
RDRP_BPSPRNA-directed RNA polymerase beta chain (EC 2.7.7.48) (RNA replicase beta chain)
VA1_BPSPReadthrough protein A1
VASS_BPSPMaturation protein (A2)

4 entries

Enterobacteria phage fr (Bacteriophage fr)

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COAT_BPFRCoat protein
RDRP_BPFRRNA-directed RNA polymerase beta chain (EC 2.7.7.48) (RNA replicase beta chain)
VASS_BPFRAssembly protein (Maturation protein) (A protein)
VLYS_BPFRLysis protein

2 entries

Enterobacteria phage JP34 (Bacteriophage JP34)

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COAT_BPJP3Coat protein
VLYS_BPJP3Lysis protein

2 entries

Enterobacteria phage Qbeta (Bacteriophage Q-beta)

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COAT_BPQBECoat protein
RDRP_BPQBERNA-directed RNA polymerase beta chain (EC 2.7.7.48) (RNA replicase beta chain)

1 entry

Enterobacteria phage R17 (Bacteriophage R17)


COAT_BPR17Coat protein

1 entry

Enterobacteria phage ZR (Bacteriophage ZR)


COAT_BPZRCoat protein

1 entry

Enterobacteria phage f2 (Bacteriophage f2)


COAT_BPF2Coat protein

1 entry

Pseudomonas phage PP7 (Bacteriophage PP7)


COAT_BPPP7Coat protein

1 entry

Pseudomonas phage PRR1 (Bacteriophage PRR1)


COAT_BPPRRCoat protein