Entomopoxvirinae

VIRION

Enveloped, brick-shaped or ovoid virion, 70-250×350nm in size. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 250-380kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).
  9. Mature virion can be occluded in spheroids comprised of spheroidin protein.

Host-virus interaction

Apoptosis modulation

The Amsacta moorei entomopoxvirus encodes AMV p33, a functional homolog of the baculovirus apoptosis inhibitor p35 . P33 is a direct inhibitor of caspases.

Matching UniProtKB/Swiss-Prot entries

24 entries grouped by strain (browse by keywords)

All proteins are shown (view only 16 complete proteome entries)

11 entries

Amsacta moorei entomopoxvirus (AmEPV) reference strain

Select_all Deselect_all  
A28_AMEPVEnvelope protein A28 homolog (Protein G4R)
I7_AMEPVCore protease I7 homolog (EC 3.4.22.-)
KITH_AMEPVThymidine kinase (EC 2.7.1.21)
NMT_AMEPVPutative glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) ...
NTP1_AMEPVNucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate ...
PTPH_AMEPVPutative tyrosine-protein phosphatase AMV078 (EC 3.1.3.48)
SPHR_AMEPVSpheroidin
V183_AMEPVUncharacterized protein AMV183/G2R
V185_AMEPVUncharacterized protein AMV185/G3L
Y014_AMEPVUncharacterized leucine-rich repeat-containing protein AMV014/Q3
YO17_AMEPVUncharacterized protein AMV017/Q1

5 entries

Melanoplus sanguinipes entomopoxvirus (MsEPV)

Select_all Deselect_all  
ETF1_MSEPVEarly transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase ...
ETF2_MSEPVEarly transcription factor 82 kDa subunit (ETF large subunit)
NMT_MSEPVPutative glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) ...
NPH2_MSEPVRNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) ...
NTP1_MSEPVNucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate ...

4 entries

Choristoneura biennis entomopoxvirus (CbEPV)

Select_all Deselect_all  
DPOL_CBEPVDNA polymerase (EC 2.7.7.7)
KITH_CBEPVThymidine kinase (EC 2.7.1.21)
NTP1_CBEPVNucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate ...
SPIN_CBEPVSpindolin (Spheroidin) (p50)

2 entries

Choristoneura fumiferana entomopoxvirus (CfEPV)

Select_all Deselect_all  
KITH_CFEPVThymidine kinase (EC 2.7.1.21)
NTP1_CFEPVNucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate ...

2 entries

Heliothis armigera entomopoxvirus (HaEPV)

Select_all Deselect_all  
NTP1_HAEPVNucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate ...
SPIN_HAEPVSpindolin (Fusolin) (p50)