Vesiculovirus

Molecular biology

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Host gene expression shutoff

Vesicular stomatitis virus matrix protein blocks nuclear pores, resulting in host mRNA nuclear export inhibiton This shutoff of host gene expression prevents effective antiviral response by the infected cell.

Matching UniProtKB/Swiss-Prot entries

57 entries grouped by strain (browse by keywords)

All proteins are shown (view only 40 complete proteome entries)

6 entries

Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain

Select_all Deselect_all  
C_VSIVAProtein C'
L_VSIVARNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_VSIVAMatrix protein
NCAP_VSIVANucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_VSIVAPhosphoprotein (P protein) (Protein M1)
VGLG_VSIVAGlycoprotein G

6 entries

Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

Select_all Deselect_all  
C_VSIVSProtein C'
L_VSIVSRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_VSIVSMatrix protein
NCAP_VSIVSNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_VSIVSPhosphoprotein (Protein P) (NS) (Protein M1)
VGLG_VSIVSGlycoprotein G

6 entries

Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)

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C_VSIVCProtein C'
L_VSIVCRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_VSIVCMatrix protein
NCAP_VSIVCNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_VSIVCPhosphoprotein (Protein P) (NS) (Protein M1)
VGLG_VSIVCGlycoprotein G

6 entries

Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)

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C_VSIVNProtein C'
L_VSIVNRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_VSIVNMatrix protein
NCAP_VSIVNNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_VSIVNPhosphoprotein (Protein P) (NS) (Protein M1)
VGLG_VSIVNGlycoprotein G

6 entries

Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV)

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C_VSNJOProtein C'
L_VSNJORNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_VSNJOMatrix protein
NCAP_VSNJONucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_VSNJOPhosphoprotein (P protein) (Protein M1)
VGLG_VSNJOGlycoprotein G

5 entries

Chandipura virus (strain I653514) (CHPV)

Select_all Deselect_all  
L_CHAVRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_CHAVMatrix protein
NCAP_CHAVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_CHAVPhosphoprotein (Protein P) (Protein M1)
VGLG_CHAVGlycoprotein G

5 entries

Isfahan virus (ISFV)

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L_ISFVRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_ISFVMatrix protein
NCAP_ISFVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ISFVPhosphoprotein (Protein P) (Protein M1)
VGLG_ISFVGlycoprotein G

5 entries

Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)

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C_VSIVGProtein C'
MATRX_VSIVGMatrix protein
NCAP_VSIVGNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_VSIVGPhosphoprotein (Protein P) (Protein M1)
VGLG_VSIVGGlycoprotein G

4 entries

Piry virus (PIRYV)

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MATRX_PIRYVMatrix protein
NCAP_PIRYVNucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_PIRYVPhosphoprotein (Protein P) (Protein M1)
VGLG_PIRYVGlycoprotein G

3 entries

Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)

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C_VSIVMProtein C'
L_VSIVMRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
PHOSP_VSIVMPhosphoprotein (Protein P) (Protein M1)

2 entries

Vesicular stomatitis New Jersey virus (strain Missouri subtype Hazelhurst) (VSNJV)

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C_VSNJMProtein C'
PHOSP_VSNJMPhosphoprotein (Protein P) (Protein M1)

1 entry

Cocal virus (COCV)


VGLG_COCAVGlycoprotein G

1 entry

Vesicular stomatitis Indiana virus (strain Orsay) (VSIV)


VGLG_VSIVOGlycoprotein G

1 entry

Vesicular stomatitis New Jersey virus (strain Hazelhurst subtype Hazelhurst) (VSNJV)


L_VSNJHRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...