Carlavirus

VIRION

Non-enveloped, flexuous, filamentous,470-1000 nm or more long and 12-13 nm in diameter.

GENOME

Linear ssRNA(+) genome of 5.8-9 kb in size. The 3’ terminus is polyadenylated and, in some genera, the 5’ end is capped. Encodes 3 to 6 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. The other ORFS are transcribed presumably as monocistronic subgenomic mRNAs (sgRNAs).

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5’-proximal ORF).
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Internal subgenomic promoters are used to transcribe the sgRNAs. Traduction of these sgRNAs yields the capsid and movement proteins.
  7. Assembly of new virus particles.
  8. Triple gene block proteins (TGBp) allow cell-to-cell and long-distance movement.

Host-virus interaction

Suppression of RNA silencing

Potato virus M cysteine-rich protein (ORF6) and TGBp1 proteins act as suppressors of RNA silencing, the former inhibiting both local and systemic silencing, whereas the latter inhibits systemic silencing .

Matching UniProtKB/Swiss-Prot entries

31 entries grouped by strain (browse by keywords)

All proteins are shown (view only 6 complete proteome entries)

6 entries

Potato virus M (strain Russian) (PVM) reference strain

Select_all Deselect_all  
COAT_PVMRCoat protein (Capsid protein) (CP)
RDRP_PVMRRNA replication protein (147 kDa protein) (ORF1 protein)
TGB1_PVMRMovement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor ...
TGB2_PVMRMovement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB3_PVMRMovement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
VSR_PVMRRNA silencing suppressor (10.7 kDa protein) (Putative nucleic acid-binding ...

5 entries

Chrysanthemum virus B (CVB)

Select_all Deselect_all  
COAT_CVBCoat protein (Capsid protein) (CP)
TGB1_CVBMovement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor ...
TGB2_CVBMovement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB3_CVBMovement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
VSR_CVBRNA silencing suppressor (12.6 kDa protein) (Putative nucleic acid-binding ...

5 entries

Lily symptomless virus (LSV)

Select_all Deselect_all  
COAT_LSVCoat protein (Capsid protein) (CP)
TGB1_LSVMovement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor ...
TGB2_LSVMovement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB3_LSVMovement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
VSR_LSVRNA silencing suppressor (16 kDa protein) (ORF6 protein) (Putative nucleic ...

5 entries

Potato virus S (strain Peruvian)

Select_all Deselect_all  
COAT_PVSPCoat protein (Capsid protein) (CP)
TGB1_PVSPMovement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor ...
TGB2_PVSPMovement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)
TGB3_PVSPMovement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
VSR_PVSPRNA silencing suppressor (10.7 kDa protein) (Putative nucleic acid-binding ...

4 entries

Poplar mosaic virus (isolate ATCC Pv275) (PMV)

Select_all Deselect_all  
COAT_POPMVCoat protein (Capsid protein) (CP)
TGB1_POPMVMovement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor ...
TGB3_POPMVMovement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
VSR_POPMVRNA silencing suppressor (14 kDa protein) (Putative nucleic acid-binding ...

2 entries

Carnation latent virus (CLV)

Select_all Deselect_all  
TGB3_CLVMovement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)
VSR_CLVRNA silencing suppressor (11.6 kDa protein) (Putative nucleic acid-binding ...

2 entries

Helenium virus S (HelVS)

Select_all Deselect_all  
COAT_HELVSCoat protein (Capsid protein) (CP)
VSR_HELVSRNA silencing suppressor (12.6 kDa protein) (Putative nucleic acid-binding ...

2 entries

Potato virus M (strain German) (PVM)

Select_all Deselect_all  
COAT_PVMGCoat protein (Capsid protein) (CP)
VSR_PVMGRNA silencing suppressor (12 kDa protein) (Cysteine-rich protein) (CRP) ...