Trichovirus

VIRION

Non-enveloped, flexuous, filamentous,640-760 nm long and 10-12 nm in diameter.

GENOME

Linear ssRNA(+) genome of 7.5-8.0 kb in size. The 3’ terminus is polyadenylated. Encodes for 3 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. ORF2 protein is translated by subgenomic RNA.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5’-proximal ORF).
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Internal subgenomic promoters are used to transcribe the sgRNAs. Traduction of these sgRNAs yields the capsid and movement proteins.
  7. Assembly of new virus particles.
  8. Movement protein allows cell-to-cell movement.

Host-virus interaction

Suppression of RNA silencing

Apple chlorotic leaf spot virus 50 kDa movement protein acts as a systemic suppressor of RNA silencing through phloem .

Matching UniProtKB/Swiss-Prot entries

6 entries grouped by strain (browse by keywords)

3 entries

Apple chlorotic leaf spot virus (isolate plum P863) (ACLSV) reference strain

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COAT_ACLSPCoat protein
MP_ACLSPPutative movement protein (50.8 kDa protein) (ORF2 protein)
RDRP_ACLSPRNA-directed RNA polymerase (EC 2.7.7.48) (216.5 kDa protein) (ORF1 protein) ...

3 entries

Apple chlorotic leaf spot virus (isolate apple) (ACLSV)

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COAT_ACLSACoat protein
MP_ACLSAPutative movement protein (50.4 kDa protein) (ORF2 protein)
RDRP_ACLSARNA-directed RNA polymerase (EC 2.7.7.48) (216.5 kDa protein) (ORF1 protein) ...