Ascovirus

VIRION

Virions consist of an envelope, a core, and an internal lipid membrane associated with the inner particle. Virion can be bacilliform, ovoidal or allantoid in shape, mesuring about 130 nm in diameter, by 200-400 nm in length. Contains at least 15 different proteins.

GENOME

Circular, dsDNA genome of 156-186 kb. The genome contains two tandem of inverted repeats.

GENE EXPRESSION

Encode for up to 180 open reading frames.

REPLICATION

NUCLEUS

  1. Attachment of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane occurs; and the viral DNA is released into the nucleus.
  3. Transcription of viral genes, replication of the DNA genome in the nucleus.
  4. Cell nucleus enlarges and ruptures.
  5. Assembly of new virions in the cytoplasm.
  6. Host cell is cleaved in cluster of virion-containing vesicles.

Host-virus interaction

Apoptosis modulation

The Spodoptera frugiperda ascovirus encodes a viral caspase that is able to induce apoptosis in insect cells.

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by strain (browse by keywords)

12 entries

Heliothis virescens ascovirus 3e (HvAV-3e) reference strain

Select_all Deselect_all  
CAPSD_HVAVEMajor capsid protein
CSPL_HVAVECaspase-like protein
DPOL_HVAVEDNA polymerase (EC 2.7.7.7)
ESTE_HVAVEPutative esterase (EC 3.1.1.-)
HELI1_HVAVEPutative ATP-dependent RNA helicase (EC 3.6.4.13)
MMP_HVAVEPutative matrix metalloproteinase (EC 3.4.24.-)
Y017_HVAVEUncharacterized protein ORF17
Y018_HVAVEUncharacterized protein ORF18
Y057_HVAVEUncharacterized protein ORF57
Y058_HVAVEUncharacterized protein ORF58
Y059_HVAVEUncharacterized protein ORF59
Y146_HVAVEPutative structural protein ORF146

11 entries

Spodoptera frugiperda ascovirus 1a (SfAV-1a) reference strain

Select_all Deselect_all  
CAPSD_SFAVAMajor capsid protein
CASP_SFAVAExecutioner caspase (EC 3.4.22.-)
DPOL_SFAVADNA polymerase (EC 2.7.7.7)
ESTE_SFAVAPutative esterase (EC 3.1.1.-)
HELI1_SFAVAPutative ATP-dependent RNA helicase (EC 3.6.4.13)
MMP_SFAVAPutative matrix metalloproteinase (EC 3.4.24.-)
Y011_SFAVAUncharacterized protein ORF11
Y012_SFAVAUncharacterized protein ORF12
Y042_SFAVAUncharacterized protein ORF42
Y043_SFAVAUncharacterized protein ORF43
Y084_SFAVAPutative structural protein ORF84

11 entries

Trichoplusia ni ascovirus 2c (TnAV-2c) reference strain

Select_all Deselect_all  
CAPSD_TNAVCMajor capsid protein
CSPL_TNAVCCaspase-like protein
DPOL_TNAVCDNA polymerase (EC 2.7.7.7)
HELI1_TNAVCPutative ATP-dependent RNA helicase (EC 3.6.4.13)
MMP_TNAVCPutative matrix metalloproteinase (EC 3.4.24.-)
Y043_TNAVCStructural protein ORF43
Y142_TNAVCStructural protein ORF142
Y147_TNAVCStructural protein ORF147
Y148_TNAVCUncharacterized protein ORF148
Y149_TNAVCUncharacterized protein ORF149
Y150_TNAVCUncharacterized protein ORF150