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Crinivirus

VIRION

Non-enveloped, bipartite filamentous particles about 650-850 nm and 700-900 nm in length, and 10-13 nm in diameter. The virion body is assembled by the major capsid protein (CP) and the tail by the minor capsid protein (CPm).

GENOME

Bi-partite linear ssRNA(+) genome of 15.3 to 17.6 kb. 3’ terminus has no poly(A) tract and the 5’ terminus probably has a methylated nucleotide cap.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. ORF1a and ORF1ab protein (containing RdRp) are produced by ribosomal frameshifting. Other ORFs are translated from a set of nested 3’ co-terminal subgenomic RNAs.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the other viral proteins.
  7. Assembly of new virus particles.
  8. Viral movement proteins mediate virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Sweet potato chlorotic stunt virus and Tomato chlorosis virus p22 proteins also function as suppressors of RNA silencing

Matching UniProtKB/Swiss-Prot entries

9 entries grouped by strain (browse by keywords)

9 entries

Lettuce infectious yellows virus (isolate United States/92) (LIYV) reference strain

Select_all Deselect_all  
CAPSD_LIYV9Capsid protein (CP) (Coat protein)
CPM_LIYV9Minor capsid protein (CPm)
MVP_LIYV9Movement protein Hsp70h (Heat shock protein 70 homolog) (Hsp70h)
P26_LIYV9Protein p26
P34_LIYV9RNA-binding P34 protein (P34)
P59_LIYV9Protein p59
P9_LIYV9Protein P9
R1AB_LIYV9Replicase polyprotein 1ab
R1A_LIYV9Replicase polyprotein 1a