Muscavirus

VIRION

Rod-shaped, enveloped virions that measure 65-80×550-680 nm with an inner, 50 nm diameter nucleocapsid containing a DNA-protein core.

GENOME

Circular, dsDNA genome of about 124 kb with 108 putative non-overlapping ORFs that are almost equally distributed over both DNA strands.

GENE EXPRESSION

Codes for 108 open reading frames.

REPLICATION

NUCLEUS

  1. Virus attachment to host receptors and internalization.
  2. Fusion of virus membrane with the vesicle membrane occurs; DNA genome is released into the nucleus.
  3. Transcription of viral genes, replication of the DNA genome in the nucleus.
  4. Assembly of new virions in the nucleus and cytoplasm.
  5. Virions bud from the cell membrane.