Nepovirus (taxid:12270)
VIRION

Non-enveloped, 28-30 nm in diameter, pseudo T=3 icosahedral capsid. The large capsid protein (CP) contains the 3 jelly rolls domains characteristic of the picornavirales . Genomic RNAs are encapsidated separately into two different types of particle similar in size.
GENOME
Segmented, bipartite linear ssRNA(+) genome composed of RNA-1=7.5 kb and RNA-2=3.9 kb. Each genomic segment has a VPg linked to its 5' end and a 3' poly(A) tract.
GENE EXPRESSION
The virion RNA is infectious and serves as both the genome and mRNA.
RNA-1 and RNA-2 are translated into two polyproteins, which are then processed into functional proteins. RNA-1 encodes proteins necessary for replication, while RNA-2 encodes for capsid protein and product(s) involved in cell-to-cell movement.
ENZYMES
- RNA-dependent RNA polymerase [RdRp]
- VPG-type capping [VPg]
- NTPase-helicase [Hel]
- Polyprotein major protease (Peptidase C3) [Pro]
REPLICATION
CYTOPLASMIC
- Virus penetrates into the cell.
- Uncoating, and release of the viral genomic RNA into the cytoplasm.
- Synthesis and proteolytic cleavage of the replicase polyprotein RNA-1.
- Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
- The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
- Assembly of new virus particles.
- Movement protein allows cell-to-cell movement.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)29 entries grouped by strain
4 entries
Tomato ringspot virus (isolate raspberry) (ToRSV) reference strain
3 entries
Beet ringspot virus (BRSV) (Tomato black ring virus (strain S))
3 entries
Grapevine fanleaf virus (GFLV)
3 entries
Tobacco ringspot virus (TobRV) (TRSV)
2 entries
Arabis mosaic virus (isolate NW) (ArMV)
2 entries
Blackcurrant reversion association virus (BRAV)
2 entries
Cycas necrotic stunt virus (CNSV)
2 entries
Grapevine chrome mosaic virus (GCMV) (Hungarian grapevine chrome mosaic virus)
2 entries
Raspberry ringspot virus (strain cherry) (RpRSV)
1 entry
Arabis mosaic virus (isolate Syrah) (ArMV)
1 entry
Grapevine fanleaf virus (isolate NW) (GFLV)
1 entry
Raspberry ringspot virus (strain S) (RpRSV)
1 entry
Tomato black ring virus (strain E) (TBRV)
1 entry
Tomato black ring virus (strain L) (TBRV)
1 entry
Tomato black ring virus (strain MJ) (TBRV)
Petunia chlorotic mottle virus taxid:1935922
Protein | ModelArchive |
Polyprotein | ma-jd-viral-08197 |
Potato black ringspot virus taxid:257464
Protein | ModelArchive |
RNA 2 polyprotein | ma-jd-viral-08194 |
Soybean latent spherical virus taxid:1927714
Protein | ModelArchive |
Polyprotein | ma-jd-viral-08193 |