Marseillevirus marseillevirus

Molecular biology

VIRION

Icosahedral virion with a diameter of about 250nm. Source:

GENOME

Circular, dsDNA genome of about 368kb that encodes potentially for 457 ORFs.

GENE EXPRESSION

Undocumented

REPLICATION

NUCLEO-CYTOPLASMIC Replication cycle lasts 5 hours ex-vivo.

  1. Virion binds to host cell and enters into host cell by phagocytosis
  2. Fusion of viral envelope with cellular membrane, inducing the release of viral DNA into host cytoplasm.
  3. Host cell nucleus shrinks, indicating possible degradation of host chromosomes.
  4. Synthesis of early proteins.
  5. Replication of genomic DNA.
  6. Late proteins synthesis, assembly of new virions in the cytoplasmic factories
  7. Cell lysis and virion release in the extracellular space.