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Nodaviridae

VIRION

Non enveloped virion, about 30 nm in diameter with a T=3 icosahedral symmetry (180 protein subunits).


GENOME

Segmented, bipartite linear, ssRNA(+) genome composed of RNA1=3.1 kb and RNA2=1.4 kb. Each genome segment 5’ end is capped. The 3’end has no poly (A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA1 encodes directly the RNA-dependent RNA polymerase (protein A), and RNA2, the capsid protein. A subgenomic RNA (sgRNA3), 3’ co-linear to RNA1 is also produced and encode proteins B1 and B2.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA-1 is translated to produce the RdRp protein.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the subgenomic RNA-3.
  7. Translation of RNA-2 encoding capsid protein alpha.
  8. Virus assembly in the cytoplasm around genomic RNA1 and RNA2.
  9. Assembled capsid protein alpha is cleaved into capsid protein beta and gamma.
  10. Release of infectious particles (lysis?).

Host-virus interaction

Suppression of RNA silencing

Nodamuravirus protein B2 and Flock house virus protein B2 act as suppressors of RNA silencing .

Matching UniProtKB/Swiss-Prot entries

23 entries grouped by strain (browse by keywords)

All proteins are shown (view only 6 complete proteome entries)

3 entries

Nodamura virus (strain Mag115) (NoV) reference strain

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B2_NODAMProtein B2
CAPSD_NODAMCapsid protein alpha
RDRP_NODAMRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

3 entries

Striped jack nervous necrosis virus (SjNNV) reference strain

Select_all Deselect_all  
B_SJNNVProtein B
CAPSD_SJNNVCapsid protein alpha
RDRP_SJNNVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

4 entries

Black beetle virus (BBV)

Select_all Deselect_all  
B1_BBVProtein B1
B2_BBVProtein B2
CAPSD_BBVCapsid protein alpha
RDRP_BBVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

4 entries

Flock house virus (FHV)

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B1_FHVProtein B1
B2_FHVProtein B2
CAPSD_FHVCapsid protein alpha
RDRP_FHVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

3 entries

Boolarra virus (BoV)

Select_all Deselect_all  
B2_BOOLVProtein B2
CAPSD_BOOLVCapsid protein alpha
RDRP_BOOLVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

2 entries

Pariacoto virus (PaV)

Select_all Deselect_all  
CAPSD_PAVCapsid protein alpha
RDRP_PAVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

1 entry

Atlantic halibut nervous necrosis virus (AhNNV)


RDRP_AHNNVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

1 entry

Greasy grouper nervous necrosis virus (GGNNV) (Epinephelus tauvina nervous necrosis virus)


RDRP_GGNNVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase) (Protein A)

1 entry

Macrobrachium rosenbergii nodavirus (MrNV)


RDRP_MRNVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase)

1 entry

Pieris rapae virus


RDRP_PRVRNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (RNA replicase)