Arenaviridae

Molecular biology

VIRION

Enveloped, spherical. Diameter from 60 to 300 nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is about 7,5 kb and S segment 3,5 kb.
Encodes for four proteins.

GENE EXPRESSION

Both segments are ambisense. The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes a messager RNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped, probably by L protein during synthesis.

REPLICATION

CYTOPLASM

  1. Virus attaches to host receptors though GP glycoprotein and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the Z protein under the plasma membrane and buds, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The Z protein plays a role in inhibition of antiviral signaling through RIG-I

Matching UniProtKB/Swiss-Prot entries

87 entries grouped by strain (browse by keywords)

All proteins are shown (view only 66 complete proteome entries)

4 entries

Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain

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GLYC_LASSJPre-glycoprotein polyprotein GP complex
L_LASSJRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_LASSJNucleoprotein (Nucleocapsid protein) (Protein N)
Z_LASSJRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain

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GLYC_LYCVAPre-glycoprotein polyprotein GP complex
L_LYCVARNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_LYCVANucleoprotein (Nucleocapsid protein) (Protein N)
Z_LYCVARING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain

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GLYC_TACVFPre-glycoprotein polyprotein GP complex
L_TACVFRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_TACVFNucleoprotein (Nucleocapsid protein) (Protein N)
Z_TACVFRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Allpahuayo virus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)

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GLYC_ALLVPPre-glycoprotein polyprotein GP complex
L_ALLVPRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_ALLVPNucleoprotein (Nucleocapsid protein) (Protein N)
Z_ALLVPRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Bear canyon virus (isolate Mouse/United States/AV A0070039/2000) (BCNV)

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GLYC_BCNVUPre-glycoprotein polyprotein GP complex
L_BCNVURNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_BCNVUNucleoprotein (Nucleocapsid protein) (Protein N)
Z_BCNVURING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Chapare virus (isolate Human/Bolivia/810419/2003)

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GLYC_CHAVBPre-glycoprotein polyprotein GP complex
L_CHAVBRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_CHAVBNucleoprotein (Nucleocapsid protein) (Protein N)
Z_CHAVBRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Cupixi virus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)

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GLYC_CPXVBPre-glycoprotein polyprotein GP complex
L_CPXVBRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_CPXVBNucleoprotein (Nucleocapsid protein) (Protein N)
Z_CPXVBRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Guanarito virus (isolate Human/Venezuela/NH-95551/1990) (GTOV)

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GLYC_GTOVVPre-glycoprotein polyprotein GP complex
L_GTOVVRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_GTOVVNucleoprotein (Nucleocapsid protein) (Protein N)
Z_GTOVVRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Ippy virus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)

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GLYC_IPPYVPre-glycoprotein polyprotein GP complex
L_IPPYVRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_IPPYVNucleoprotein (Nucleocapsid protein) (Protein N)
Z_IPPYVRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Junin arenavirus (JUNV)

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GLYC_JUNINPre-glycoprotein polyprotein GP complex
L_JUNINRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_JUNINNucleoprotein (Nucleocapsid protein) (Protein N)
Z_JUNINRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Latino virus (isolate Rat/Bolivia/MARU 1924/1965) (LATV)

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GLYC_LATVBPre-glycoprotein polyprotein GP complex
L_LATVBRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_LATVBNucleoprotein (Nucleocapsid protein) (Protein N)
Z_LATVBRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Machupo virus (MACV)

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GLYC_MACHUPre-glycoprotein polyprotein GP complex
L_MACHURNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_MACHUNucleoprotein (Protein N) (Nucleocapsid protein)
Z_MACHURING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Mobala virus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)

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GLYC_MOBVCPre-glycoprotein polyprotein GP complex
L_MOBVCRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_MOBVCNucleoprotein (Nucleocapsid protein) (Protein N)
Z_MOBVCRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Oliveros virus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)

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GLYC_OLVVAPre-glycoprotein polyprotein GP complex
L_OLVVARNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_OLVVANucleoprotein (Nucleocapsid protein) (Protein N)
Z_OLVVARING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Parana virus (isolate Rat/Paraguay/12056/1965) (PARV)

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GLYC_PARVPPre-glycoprotein polyprotein GP complex
L_PARVPRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_PARVPNucleoprotein (Nucleocapsid protein) (Protein N)
Z_PARVPRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Pirital virus (isolate Rat/Venezuela/VAV-488/1995) (PIRV)

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GLYC_PIRVVPre-glycoprotein polyprotein GP complex
L_PIRVVRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_PIRVVNucleoprotein (Nucleocapsid protein) (Protein N)
Z_PIRVVRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Sabia virus (isolate Human/Brasil/SPH114202/1990) (SABV)

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GLYC_SABVBPre-glycoprotein polyprotein GP complex
L_SABVBRNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_SABVBNucleoprotein (Nucleocapsid protein) (Protein N)
Z_SABVBRING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Tamiami virus (isolate Rat/United States/W 10777/1964) (TAMV)

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GLYC_TAMVUPre-glycoprotein polyprotein GP complex
L_TAMVURNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_TAMVUNucleoprotein (Nucleocapsid protein) (Protein N)
Z_TAMVURING finger protein Z (Protein Z) (Zinc-binding protein)

4 entries

Whitewater arroyo virus (isolate Rat/United States/AV 9310135/1995) (WWAV)

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GLYC_WWAVUPre-glycoprotein polyprotein GP complex
L_WWAVURNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural ...
NCAP_WWAVUNucleoprotein (Nucleocapsid protein) (Protein N)
Z_WWAVURING finger protein Z (Protein Z) (Zinc-binding protein)

2 entries

Lassa virus (strain GA391) (LASV)

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GLYC_LASSGPre-glycoprotein polyprotein GP complex (Pre-GP-C)
NCAP_LASSGNucleoprotein (Nucleocapsid protein) (Protein N)

2 entries

Lymphocytic choriomeningitis virus (strain WE) (LCMV)

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GLYC_LYCVWPre-glycoprotein polyprotein GP complex (Pre-GP-C)
NCAP_LYCVWNucleoprotein (Nucleocapsid protein) (Protein N)

2 entries

Mopeia virus (MOPV)

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GLYC_MOPEIPre-glycoprotein polyprotein GP complex (Pre-GP-C)
NCAP_MOPEINucleoprotein (Nucleocapsid protein) (Protein N)

2 entries

Pichinde arenavirus (PICV)

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GLYC_PIARVPre-glycoprotein polyprotein GP complex (Pre-GP-C)
NCAP_PIARVNucleoprotein (Nucleocapsid protein) (Protein N)

1 entry

Tacaribe virus (strain TRVL 11598) (TCRV)


GLYC_TACVTPre-glycoprotein polyprotein GP complex (Pre-GP-C)

1 entry

Tacaribe virus (strain V5) (TCRV)


GLYC_TACV5Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

1 entry

Tacaribe virus (strain V7) (TCRV)


GLYC_TACV7Pre-glycoprotein polyprotein GP complex (Pre-GP-C)