Proboscivirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome.

GENE EXPRESSION

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by strain (browse by keywords)

34 entries

Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)

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AN_ELHVKAlkaline nuclease (EC 3.1.-.-)
CEP2_ELHVKCytoplasmic envelopment protein 2
CVC1_ELHVKCapsid vertex component 1
CVC2_ELHVKCapsid vertex component 2
DNBI_ELHVKMajor DNA-binding protein
DPOL_ELHVKDNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
GB_ELHVKEnvelope glycoprotein B (gB)
GH_ELHVKEnvelope glycoprotein H (gH)
GN_ELHVKEnvelope glycoprotein N
ICP27_ELHVKmRNA export factor ICP27 homolog
KITH_ELHVKThymidine kinase (EC 2.7.1.21)
MCP_ELHVKMajor capsid protein (MCP)
ORFA_ELHVKProtein ORF A
ORFB_ELHVKProtein ORF B
ORFC_ELHVKProtein ORF C
ORFD_ELHVKProtein ORF D
PRIM_ELHVKDNA primase (EC 2.7.7.-)
SCAF_ELHVKCapsid scaffolding protein (Protease precursor) (pPR)
TEG7_ELHVKTegument protein UL51 homolog
TRM1_ELHVKTripartite terminase subunit 1
TRM3_ELHVKTripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX2_ELHVKTriplex capsid protein 2
U54_ELHVKProtein U54
U62_ELHVKProtein U62
UL24_ELHVKProtein UL24 homolog
UL79_ELHVKProtein U52
UL87_ELHVKProtein U58
UL88_ELHVKProtein U59
UL92_ELHVKProtein U63
UL95_ELHVKProtein U67
UL96_ELHVKProtein U68
UL97_ELHVKPhosphotransferase UL97 homolog (EC 2.7.1.-)
VGCR_ELHVKG-protein coupled receptor
VU4_ELHVKProtein U4