Kappapapillomavirus

VIRION

Non-enveloped. Small, icosahedral, about 52-55 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.

GENOME

Circular dsDNA, about 8 kb in size, associated with cellular histones, encoding for 6 proteins. The E6 ORF is larger than in other genera. An uncharacterized E8 ORF is present in the early region.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing :
a) Early Proteins: non-structural regulatory proteins (E1-E8).
b) Late Proteins: the structural proteins L1 and L2.

REPLICATION

NUCLEAR

Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.
b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.
  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

10 entries grouped by strain (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

8 entries

Cottontail rabbit papillomavirus (strain Kansas) (CRPV) (Papillomavirus sylvilagi) reference strain

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VE1_CRPVKReplication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE2_CRPVKRegulatory protein E2
VE4_CRPVKProbable protein E4
VE5_CRPVKProbable protein E5
VE6_CRPVKProtein E6
VE7_CRPVKProtein E7
VL1_CRPVKMajor capsid protein L1
VL2_CRPVKMinor capsid protein L2

2 entries

Cottontail rabbit papillomavirus (strain Washington B) (CRPV) (Papillomavirus sylvilagi)

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VE5_CRPVWProbable protein E5
VE7_CRPVWProtein E7