VIRION
Enveloped virion of which the membrane is surrounded by a capsid with an icosahedral symmetry (T=169), 120-150 nm in diameter. Dense material are present at each 5-fold symmetry vertex
Source: Van Etten 2003 (Pubmed)
- Hexons: Double jelly roll-fold major capsid protein [Q8QNG3]
- Pentons: Single jelly roll-fold [?]
GENOME
Linear, dsDNA genome of 150-350 kb with crosslinked hairpin ends.
GENE EXPRESSION
ENZYMES
- DNA-directed DNA polymerase family B [POL_B]
- Cell-type capping
- Protease (Peptidase S74)
- Ribonucleoside-diphosphate reductase
REPLICATION
NUCLEO-CYTOPLASMIC
- Virus attaches to host receptors , inducing release of viral genome into the cell.
- Migration of the DNA core to the nucleus?
- The viral genome can enter latency by integrating in host chromosome.
- Synthesis of early proteins.
- Replication of genomic DNA..
- Late proteins synthesis, assembly of new virions in the cytoplasm
- Cell lysis and virion release in the extracellular space.