VIRION
Enveloped virion of which the membrane is surrounded by a capsid with an icosahedral symmetry (T=169), 100-170 nm in diameter. Dense material are present at each 5-fold symmetry vertex
Source: Van Etten 2003 (Pubmed)
- Hexons: Double jelly roll-fold major capsid protein [R4THT4]
- Pentons: Single jelly roll-fold [R4TG25]
GENOME
Linear, dsDNA genome of 120-485 kb with crosslinked hairpin ends.
GENE EXPRESSION
ENZYMES
- DNA-directed DNA polymerase family B [POL_B R4TQL0]
- DNA-directed RNA polymerase [RPB10-like beta, R4TQG3, RPB6-like R4TQM7, RBP9-like
- DNA topoisomerase R4TFQ7 R4THI6
- DNA methyltransferase R4TX73
- Transposase R4THZ0
- HNH endonuclease R4TFB9
- Exonuclease R4TUS7
- Cell-type capping
- N7MTase R4TWP7
- PolyA polymerase R4TUN7
- Thymidine synthase R4TIC7
- Thymidine kinase R4TI53
- GMP reductase R4TW99
- Ribonuclease HII R4THQ2
- Exodeoxyribonuclease III R4TWA8
- dUTP phosphatase R4TIG1
- Cytidine deaminase R4TVI3
- Ribonucleoside-diphosphate reductase R4TQ72
- dihydrofolate reductase R4TFN9 R4TQ51
- Sulfhydryl oxidase R4TI15
- tRNA carboxymethyluridine synthase R4TX69
- Protease (Peptidase S74) R4TPZ5
- Protease (Peptidase C48) R4TVE7
- Protease (Peptidase C1) R4TV59
- Protease (Peptidase M41) R4TQL5
- Protein kinase R4TFY7 R4TVG2
- Asparagine synthase R4TIC1
- Ubiquitin-conjugating enzyme E2 R4TV04
- Glcosyltransferase R4TUI4
REPLICATION
NUCLEO-CYTOPLASMIC
- Virus attaches to host receptors , inducing release of viral genome into the cell.
- Migration of the DNA core to the nucleus?
- Synthesis of early proteins.
- Replication of genomic DNA..
- Late proteins synthesis, assembly of new virions in the cytoplasm
- Cell lysis and virion release in the extracellular space.