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Polerovirus

VIRION

Non-enveloped, spherical virion about 23 nm in diameter with T=3 icosahedral symmetry composed of 180 CP proteins, with some percentage containing a readthrough domain (RTD) extension located on the particle’s surface.

GENOME

Monopartite, linear, ssRNA(+) genome of 5.3-5.7 kb in size with a VPg bound at the 5’ end. There is no poly(A) tail or tRNA-like structure at the 3’ end.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The polymerase is expressed by a ribosomal frameshifting near the end of ORF1. Rap1 translation initiates about 1500 nt downstream of the 5’ end of the gRNA by an unusual internal ribosome entry site (IRES).
The movement protein is expressed by leaky scanning of the subgenomic mRNA. Suppression of termination of the CP stop codon produces CP-RTD (CP extended), the capsid subunit essential for aphid transmission.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA ORF1 and ORF2 are translated to produce the RdRp fusion protein.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of the 3’ coterminal sgRNAs. Traduction of these sgRNAs yields the capsid, CP-RTD and movement proteins.
  7. Virus assembly.
  8. Viral movement protein probably mediates virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Polerovirus protein P0 acts as a suppressor of RNA silencing by targeting Argonaute 1 for degradation .

Matching UniProtKB/Swiss-Prot entries

27 entries grouped by strain (browse by keywords)

All proteins are shown (view only 22 complete proteome entries)

8 entries

Potato leafroll virus (strain Potato/Scotland/strain 1/1984) (PLrV) reference strain

Select_all Deselect_all  
CAPSD_PLRV1Major capsid protein (Coat protein) (CP)
MCAPS_PLRV1Minor capsid protein P3-RTD (P74) (Readthrough protein) (RT protein)
MVP_PLRV1Movement protein (MP) (17 kDa protein)
P0_PLRV1Suppressor of silencing P0 (28 kDa protein) (Protein ORF0)
P1_PLRV1Protein P1 (69.7 kDa protein) (Genome-linked protein precursor) (Protein ORF1)
P6_PLRV1Uncharacterized protein P6 (ORF6 protein)
RAP1_PLRV1Replication-associated protein (Rap1)
RDRP_PLRV1Protein P1-P2

8 entries

Potato leafroll virus (strain Potato/Netherlands/Wageningen/1989) (PLrV)

Select_all Deselect_all  
CAPSD_PLRVWMajor capsid protein (Coat protein) (CP)
MCAPS_PLRVWMinor capsid protein P3-RTD (P74) (Readthrough protein) (RT protein)
MVP_PLRVWMovement protein (MP) (17 kDa protein)
P0_PLRVWSuppressor of silencing P0 (28 kDa protein) (Protein ORF0)
P1_PLRVWProtein P1 (69.7 kDa protein) (Genome-linked protein precursor) (Protein ORF1)
P6_PLRVWUncharacterized protein P6 (ORF6 protein)
RAP1_PLRVWReplication-associated protein (Rap1)
RDRP_PLRVWProtein P1-P2

6 entries

Turnip yellows virus (isolate FL-1) (TuYV) (BWYV-FL1)

Select_all Deselect_all  
CAPSD_TYYVFMajor capsid protein (Coat protein) (CP)
MCAPS_TYYVFMinor capsid protein P3-RTD (P74) (Readthrough protein) (RT protein)
MVP_TYYVFMovement protein (MP) (20 kDa protein)
P0_TYYVFSuppressor of silencing P0 (29 kDa protein) (Protein ORF0)
P1_TYYVFProtein P1 (66.2 kDa protein) (Genome-linked protein precursor) (Protein ORF1)
RDRP_TYYVFProtein P1-P2

2 entries

Potato leafroll virus (PLrV)

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CAPSD_PLRVMajor capsid protein (Coat protein) (CP)
MVP_PLRVMovement protein (MP) (17 kDa protein) (MP17)

2 entries

Potato leafroll virus (strain Potato/Canada/Rowhani/1979) (PLrV)

Select_all Deselect_all  
CAPSD_PLRVRMajor capsid protein (Coat protein) (CP)
MVP_PLRVRMovement protein (MP) (17 kDa protein)

1 entry

Beet western yellows virus (isolate GB1) (BWYV)


MVP_BWYVGMovement protein (MP) (20 kDa protein)