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Inhibition of host tetherin by virus

Tetherin is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses, including human immunodeficiency virus type 1 (HIV-1), HIV-2, other retroviruses, Lassa virus-like particles (VLPs), Marburg and Ebola VLPs.
Tetherin may also act as an innate immune sensor of viral infections that activates NF-kappaB to induce an inflammatory response.

Several viruses manage to circumvent the antiviral activity of tetherin. The Vpu protein form HIV-1 bridges tetherin to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. HIV-2 instead downregulates cell surface expression of tetherin, restricting it to the trans-Golgi network via direct interaction with the viral glycoprotein.

Matching UniProtKB/Swiss-Prot entries

55 entries grouped by strain (browse by keywords)

All proteins are shown (view only 35 complete proteome entries)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain


VPU_HV1H2Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain


ENV_HV2BEEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain


VGP_EBOZMEnvelope glycoprotein (GP1,2) (GP)

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1)


VPU_HV1MAProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)


VPU_HV1A2Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)


VPU_HV1B1Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)


VPU_HV1B8Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)


VPU_HV1BRProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)


VPU_HV1BNProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)


VPU_HV1C4Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)


VPU_HV1H3Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JH32) (HIV-1)


VPU_HV1J3Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)


VPU_HV1JRProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)


VPU_HV1LWProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1)


VPU_HV1MNProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)


VPU_HV1RHProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)


VPU_HV1SCProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)


VPU_HV1S1Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)


VPU_HV1Y2Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)


VPU_HV1B9Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)


VPU_HV192Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1)


VPU_HV1ETProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1)


VPU_HV1ELProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)


VPU_HV1NDProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)


VPU_HV1Z2Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)


VPU_HV193Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1)


VPU_HV1VIProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)


VPU_HV190Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype U (isolate Z3) (HIV-1)


VPU_HV1Z3Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)


VPU_HV1YBProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1)


VPU_HV1YFProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)


VPU_HV1ANProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)


VPU_HV1MVProtein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)


ENV_HV2CAEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)


ENV_HV2D1Envelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)


ENV_HV2G1Envelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)


ENV_HV2KREnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2)


ENV_HV2NZEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)


ENV_HV2ROEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)


ENV_HV2SBEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2)


ENV_HV2STEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ST/24.1C#2) (HIV-2)


ENV_HV2S2Envelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2)


ENV_HV2D2Envelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)


ENV_HV2EHEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)


ENV_HV2UCEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)


VGP_EBOREEnvelope glycoprotein (GP1,2) (GP)

1 entry

Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)


VGP_EBORREnvelope glycoprotein (GP1,2) (GP)

1 entry

Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)


VGP_EBORSEnvelope glycoprotein (GP1,2) (GP)

1 entry

Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)


VGP_EBOSBEnvelope glycoprotein (GP1,2) (GP)

1 entry

Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)


VGP_EBOSMEnvelope glycoprotein (GP1,2) (GP)

1 entry

Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)


VGP_EBOSUEnvelope glycoprotein (GP1,2) (GP)

1 entry

Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus)


VGP_TAFVCEnvelope glycoprotein (GP1,2) (GP)

1 entry

Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)


VGP_EBOECEnvelope glycoprotein (GP1,2) (GP)

1 entry

Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)


VGP_EBOG4Envelope glycoprotein (GP1,2) (GP)

1 entry

Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)


VGP_EBOZ5Envelope glycoprotein (GP1,2) (GP)