Gammaretrovirus

Molecular biology

VIRION

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter.

GENOME

Monopartite, linear, dimeric, ssRNA(+) genome of about 8.3 kb, with a 5’-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5’ and 3’ ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promotor elements in the 5’LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag, and gag-(pro)pol (1 ribosomal readthrough of the gag gene termination codon). The spliced mRNA encodes env that is cleaved into SU and TM envelope proteins. There are no additional genes other than gag, pro, pol and env.

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors through the SU glycoprotein. TM glycoprotein mediates fusion with cell membrane.
  2. Internalization and partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA when the nuclear membrane is disassembled at mitosis.
  5. Viral dsDNA is covalently and randomly integrated into the cell’s genome by the viral integrase (=provirus).
  6. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  7. Nuclear export of the incompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

100 entries grouped by strain (browse by keywords)

All proteins are shown (view only 37 complete proteome entries)

3 entries

Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

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ENV_MLVMSEnvelope glycoprotein (Pr80env) (Env polyprotein)
GAG_MLVMSGag polyprotein (Pr65gag) (Core polyprotein)
POL_MLVMSGag-Pol polyprotein (Pr180gag-pol)

3 entries

Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain

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ENV_XMRV6Envelope glycoprotein (Env polyprotein)
GAG_XMRV6Gag polyprotein (Pr65gag) (Core polyprotein)
POL_XMRV6Gag-Pol polyprotein (Pr180gag-pol)

3 entries

AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)

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ENV_MLVAVEnvelope glycoprotein (Env polyprotein)
GAG_MLVAVGag polyprotein (Core polyprotein)
POL_MLVAVPol polyprotein

3 entries

Abelson murine leukemia virus

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ABL_MLVABTyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)
GAG_MLVABGag polyprotein
V18K_MLVAB18 kDa protein

3 entries

Baboon endogenous virus (strain M7)

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ENV_BAEVMEnvelope glycoprotein (Env polyprotein)
GAG_BAEVMGag polyprotein (Core polyprotein)
POL_BAEVMPol polyprotein

3 entries

Feline leukemia virus

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GAG_FLVGag polyprotein (Core polyprotein)
MYC_FLVViral myc transforming protein (v-Myc)
TCB_FLVViral T-cell receptor beta chain-like T17T-22

3 entries

Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)

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ENV_FSVGAEnvelope glycoprotein (Env polyprotein)
FES_FSVGATyrosine-protein kinase transforming protein Fes (EC 2.7.10.2)
GAG_FSVGAGag polyprotein (Core polyprotein)

3 entries

Friend murine leukemia virus (isolate 57) (FrMLV)

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ENV_MLVF5Envelope glycoprotein (Env polyprotein)
GAG_MLVF5Gag polyprotein (Core polyprotein)
POL_MLVF5Pol polyprotein

3 entries

Friend murine leukemia virus (isolate FB29) (FrMLV)

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ENV_MLVFFEnvelope glycoprotein (Env polyprotein)
GAG_MLVFFGag polyprotein (Core polyprotein)
POL_MLVFFPol polyprotein

3 entries

Friend murine leukemia virus (isolate PVC-211) (FrMLV)

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ENV_MLVFPEnvelope glycoprotein (Env polyprotein)
GAG_MLVFPGag polyprotein (Core polyprotein)
POL_MLVFPPol polyprotein

3 entries

Gibbon ape leukemia virus (GALV)

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ENV_GALVEnvelope glycoprotein (Env polyprotein)
GAG_GALVGag polyprotein (Core polyprotein)
POL_GALVPol polyprotein

3 entries

Koala retrovirus (KoRV)

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ENV_KORVEnvelope glycoprotein (Env polyprotein)
GAG_KORVGag polyprotein (Core polyprotein)
POL_KORVPro-Pol polyprotein (Pr125Pol)

3 entries

Moloney murine sarcoma virus (MoMSV)

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GAG_MSVMOGag polyprotein (Core polyprotein)
MOS_MSVMOSerine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)
RASH_MSVMOGTPase HRas (Transforming protein p21/H-Ras)

3 entries

Radiation murine leukemia virus

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ENV_MLVRDEnvelope glycoprotein (Env polyprotein)
GAG_MLVRDGag polyprotein (Core polyprotein)
POL_MLVRDPol polyprotein

3 entries

Xenotropic MuLV-related virus (isolate VP35) (XMRV)

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ENV_XMRV3Envelope glycoprotein (Env polyprotein)
GAG_XMRV3Gag polyprotein (Pr65gag) (Core polyprotein)
POL_XMRV3Gag-Pol polyprotein (Pr180gag-pol)

3 entries

Xenotropic MuLV-related virus (isolate VP42) (XMRV)

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ENV_XMRV4Envelope glycoprotein (Env polyprotein)
GAG_XMRV4Gag polyprotein (Pr65gag) (Core polyprotein)
POL_XMRV4Gag-Pol polyprotein (Pr180gag-pol)

2 entries

Avian reticuloendotheliosis virus

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ENV_AVIREEnvelope glycoprotein (Env polyprotein)
REL_AVIRETransforming protein rel polyprotein (p58 V-rel)

2 entries

Cas-Br-E murine leukemia virus

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ENV_MLVCBEnvelope glycoprotein (Env polyprotein)
GAG_MLVCBGag polyprotein (Core polyprotein)

2 entries

FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)

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FOSX_MSVFRTransforming protein v-Fos/v-Fox
GAG_MSVFRGag polyprotein (Core polyprotein)

2 entries

Feline sarcoma virus (strain Gardner-Rasheed)

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FGR_FSVGRTyrosine-protein kinase transforming protein Fgr (EC 2.7.10.2)
GAG_FSVGRCore protein p15

2 entries

Feline sarcoma virus (strain McDonough)

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GAG_FSVMDGag polyprotein (Core polyprotein)
KFMS_FSVMDTyrosine-protein kinase transforming protein fms (EC 2.7.10.1)

2 entries

Feline sarcoma virus (strain Snyder-Theilen)

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FES_FSVSTTyrosine-protein kinase transforming protein Fes (EC 2.7.10.2)
GAG_FSVSTGag polyprotein (Core polyprotein)

2 entries

Friend spleen focus-forming virus (isolate 502) (FSFFV)

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ENV_FRSF5Glycoprotein 55 (gp55)
GAG_FRSF5Gag polyprotein (Core polyprotein)

2 entries

Hortulanus murine leukemia virus (HoMuLV) (Mus hortulanus virus)

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ENV_MLVHOEnvelope glycoprotein (Env polyprotein)
GAG_MLVHOGag polyprotein (Core polyprotein)

2 entries

Moloney murine sarcoma virus (strain ts110) (MoMSV)

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GAG_MSVMTGag polyprotein (Core polyprotein)
MOS_MSVMTSerine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

2 entries

Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)

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GAG_WMSVGag polyprotein (Core polyprotein)
TSIS_WMSVPDGF-related-transforming protein sis (p28sis)

1 entry

AKT8 murine leukemia virus


AKT_MLVATAKT kinase-transforming protein (EC 2.7.11.1)

1 entry

Avian spleen necrosis virus


ENV_AVISNEnvelope glycoprotein (Env polyprotein)

1 entry

Cas-NS-1 murine leukemia virus


CBL_MLVCNTransforming protein cbl

1 entry

Duplan murine leukemia virus


GAG_MLVDUGag polyprotein (Core polyprotein)

1 entry

FBJ murine osteosarcoma virus (FBJ-MSV) (Finkel-Biskis-Jinkins murine osteosarcoma virus)


FOS_MSVFBp55-v-Fos-transforming protein

1 entry

Feline endogenous virus ECE1


ENV_FENV1Envelope glycoprotein (Env polyprotein)

1 entry

Feline leukemia virus (isolate CFE-6)


ENV_FLVC6Envelope glycoprotein (Env polyprotein)

1 entry

Feline leukemia virus (strain A/Glasgow-1)


ENV_FLVGLEnvelope glycoprotein (Env polyprotein)

1 entry

Feline leukemia virus (strain B/lambda-B1)


ENV_FLVLBEnvelope glycoprotein (Env polyprotein)

1 entry

Feline leukemia virus (strain C/Sarma)


ENV_FLVSAEnvelope glycoprotein (Env polyprotein)

1 entry

Feline leukemia virus FTT


MYC_FLVTTViral myc transforming protein (v-Myc)

1 entry

Feline sarcoma virus (strain Hardy-Zuckerman 2)


ABL_FSVHYTyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)

1 entry

Feline sarcoma virus (strain Hardy-Zuckerman 4)


KIT_FSVHZTyrosine-protein kinase transforming protein kit (EC 2.7.10.1)

1 entry

Feline sarcoma virus (strain SM) (Sm-FeSV)


ENV_FSVSMEnvelope glycoprotein (Env polyprotein)

1 entry

Friend spleen focus-forming virus (strain BB6) (FSFFV)


ENV_FRSFBGlycoprotein 42 (gp42)

1 entry

Friend spleen focus-forming virus (strain Lilly-Steeves) (FSFFV)


ENV_FRSFLGlycoprotein 55 (gp55)

1 entry

Harvey murine sarcoma virus


RASH_MSVHATransforming protein p29

1 entry

Kirsten murine sarcoma virus


RASK_MSVKIGTPase KRas (Ki-Ras) (Transforming protein p21/K-Ras)

1 entry

Mink cell focus-forming murine leukemia virus


ENV_MCFFEnvelope glycoprotein (Env polyprotein)

1 entry

Mink cell focus-forming murine leukemia virus (isolate CI-3)


ENV_MCFF3Envelope glycoprotein (Env polyprotein)

1 entry

Moloney murine leukemia virus (strain neuropathogenic variant ts1-92b) (MoMLV)


GAG80_MLVMNGlycosylated Gag polyprotein (Pr80gag) (Glyco-gag) (gp80gag)

1 entry

Moloney murine sarcoma virus (strain HT-1) (MoMSV)


MOS_MSVMHSerine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Moloney murine sarcoma virus (strain m1) (MoMSV)


MOS_MSVMMSerine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Murine leukemia virus (strain BM5 eco)


GAG_MLVBMGag polyprotein (Core polyprotein)

1 entry

Murine leukemia virus (strain DEF27)


GAG_MLVDEGag polyprotein (Core polyprotein)

1 entry

Murine sarcoma virus 3611


RAF_MSV36Serine/threonine-protein kinase-transforming protein raf (EC 2.7.11.1)

1 entry

Murine sarcoma virus NS.C58


RASH_MSVNSGTPase HRas (Transforming protein p21/H-Ras)

1 entry

Myeloproliferative sarcoma virus (isolate ts159)


MOS_MSVTSSerine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Radiation murine leukemia virus (strain Kaplan)


ENV_MLVRKEnvelope glycoprotein (Env polyprotein)

1 entry

Rasheed rat sarcoma virus


RASH_RRASVTransforming protein p29

1 entry

Rauscher mink cell focus-inducing virus


ENV_RMCFVEnvelope glycoprotein (Env polyprotein)

1 entry

Rauscher spleen focus-forming virus (RSFFV)


ENV_RSFFVGlycoprotein 55 (gp55)