Human immunodeficiency virus 1

Molecular biology

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter. Mature capsid contains 1572 capsid proteins.

Monopartite, linear, dimeric, ssRNA(+) genome of 9,75 kb, with a 5’-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5’ and 3’ ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promotor elements in the 5’ LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag and gag-(pro)pol (1 ribosomal frameshift) polyproteins. The uncompletely spliced mRNAs encode env that is cleaved into SU and TM envelope proteins, and the accessory proteins vif, vpu, and vpr. Completely spliced mRNAs encode Rev, Tat and Nef accessory proteins. Rev escorts unspliced and uncompletely spliced RNAs out of the nucleus of infected cells.

REPLICATION

NUCLEAR

Lytic replication:

  1. Virus attaches to host CD4 receptors through the SU glycoprotein (gp120), with subsequent interaction with a chemokine coreceptor.
  2. Internalization via clathrin-dependent endocytosis. TM glycoprotein (gp41) mediates dynamin-dependent fusion with the host endosomal membrane. Nucleocapsid is released into the cytoplasm, with partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA which is covalently and randomly integrated into the cell’s genome by the integrase (=provirus).
  5. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  6. Translation of spliced viral RNAs produces tat, rev, and nef proteins.
  7. Rev mediates nuclear export of the uncompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Latent replication : replication as a provirus integrated in the host chromosome.

Reference strains

HIV-1 REFERENCE STRAIN HIV-1 subtype B strain HxB2
Sequence | Genome | Proteome

EXPERIMENTAL CLONE PNL4.3 pNL4-3 is a subtype B strain that is normally used as the reference sequence for HIV drug resistance studies. It is a recombinant (infectious) proviral clone that contains DNA from HIV isolates NY5 (5’ half) and BRU (3’ half). The site of recombination is the EcoRI site at positions 5743-5748.
Sequence | Proteome

GROUP O REFERENCE STRAIN Group O seems to be endemic and largely confined to Cameroon and neighboring countries in West Central Africa, where these viruses represent a small minority of HIV-1 strains. (Pubmed)

HIV-1 isolate ANT70
Sequence | Proteome

GROUP N REFERENCE STRAIN The group N is confined to Cameroon. (Pubmed)

HIV-1 isolate YBF30
Sequence | Proteome
GROUP M REFERENCE STRAINS

HIV-1 group M is responsible for the worlwide pandemy of AIDS. It is subdivised into 9 subtypes (A-F), and several CRF.
(Reference strains have been chosen in collaboration with Tulio de Oliveira, Bioafrica.net)

Subtype A1: HIV-1 isolate U455
Sequence | Proteome

Subtype B: HIV-1 strain HxB2
Sequence | Genome | Proteome

Subtype C: HIV-1 isolate TV001
Sequence | Proteome

Subtype D: HIV-1 isolate ELI
Sequence | Proteome

Subtype F1: HIV-1 isolate 93BR020
Sequence | Proteome

Subtype F2: HIV-1 isolate MP255
Sequence | Proteome

Subtype G: HIV-1 isolate 92BR025
Sequence | Proteome

Subtype H: HIV-1 isolate 90CF056
Sequence | Proteome

Subtype J: HIV-1 isolate SE9173
Sequence | Proteome

Subtype K: HIV-1 isolate 96CM-MP535
Sequence | Proteome

CRF01_AE: HIV-1 isolate 90CF11697
Sequence | Proteome

CRF02_AG: HIV-1 isolate 97CM.MP807
Sequence | Proteome

Epidemiology

Global map of HIV infection source WHO/UNAIDS

HIV subtypes

HIV viruses are subdivised into groups, subtypes and CRF. Groups N and O are recent and so far restricted to cameroon. The vast majority of HIV-1 strains found worldwide belongs to Group M (Major). This group is subdivised into 9 subtypes (A-F), and several CRF (circulating recombinant form).

Source Peeters, M.

Replication cycle

  1. Virus attaches to host CD4 receptors through the SU glycoprotein (gp120), with subsequent interaction with a chemokine coreceptor.
  2. Internalization via clathrin-dependent endocytosis. TM glycoprotein (gp41) mediates dynamin-dependent fusion with the host endosomal membrane. Nucleocapsid is released into the cytoplasm, with partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA which is covalently and randomly integrated into the cell’s genome by the integrase (=provirus).
  5. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  6. Translation of spliced viral RNAs produces tat, rev, and nef proteins.
  7. Rev mediates nuclear export of the uncompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

353 entries grouped by strain (browse by keywords)

All proteins are shown (view only 180 complete proteome entries)

9 entries

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

Select_all Deselect_all  
ENV_HV1MAEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1MAGag polyprotein (Pr55Gag)
NEF_HV1MAProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1MAGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1MAProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1MAProtein Tat (Transactivating regulatory protein)
VIF_HV1MAVirion infectivity factor (Vif) (SOR protein)
VPR_HV1MAProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1MAProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain

Select_all Deselect_all  
ENV_HV1B1Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1B1Gag polyprotein (Pr55Gag)
NEF_HV1B1Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1B1Gag-Pol polyprotein (Pr160Gag-Pol)

pdb 1A9M  1AJV  1AJX  1AXA  1BQM  1BQN  1D4H  1D4I  1D4J  1DLO  1DW6  1EBK  1EBW  1EBY  1EBZ  1EC0  1EC1  1EC2  1EC3  1EET  1G35  1GNM  1GNN  1GNO  1HAR  1HBV  1HEF  1HEG  1HIH  1HMV  1HNI  1HNV  1HOS  1HPS  1HPZ  1HQE  1HQU  1HRH  1HTE  1HTF  1HTG  1HVI  1HVK  1HVP  1HVU  1HYS  1IKV  1IKW  1IKX  1IKY  1J5O  1KJH  1MER  1MES  1MET  1MEU  1N5Y  1N6Q  1NPA  1NPV  1NPW  1QE1  1QMC  1R0A  1RDH  1RTD  1RVL  1RVM  1RVN  1RVO  1RVP  1RVQ  1RVR  1S6P  1S6Q  1S9E  1S9G  1SBG  1SUQ  1SV5  1T03  1T05  1T7K  1TV6  1TVR  1UWB  1W5V  1W5W  1W5X  1W5Y  1YT9  1ZP8  1ZPA  1ZSF  1ZSR  2AQU  2B5J  2B6A  2BAN  2BBB  2BE2  2EXF  2G69  2HB3  2HMI  2HNZ  2HS1  2HS2  2I4D  2I4U  2I4V  2I4W  2I4X  2I5J  2IAJ  2IC3  2IDW  2IEO  2JZW  2L45  2L46  2L4L  2UXZ  2UY0  2VG5  2VG6  2VG7  2X4U  2YKM  2YKN  2ZD1  2ZE2  3AVI  3BGR  3DLK  3GGA  3GGV  3GGX  3HVT  3IG1  3IRX  3IS9  3ISN  3ITH  3JSM  3JYT  3K2P  3K4V  3KLE  3KLF  3KLG  3KLH  3KLI  3NDT  3NU3  3NU4  3NU5  3NU6  3NU9  3NUJ  3NUO  3OK9  3PSU  3QAA  3QLH  3QO9  3TKG  3TKW  3TL9  3TLH  3V4I  3V6D  3V81  3ZPS  3ZPT  3ZPU  4COE  4CP7  4CPQ  4CPR  4CPS  4CPT  4CPU  4CPW  4CPX  4DG1  4G1Q  4G8G  4G8I  4G9D  4G9F  4H4M  4H4O  4I2P  4I2Q  4ICL  4ID5  4IDK  4IFV  4IFY  4IG0  4IG3  4KFB  4KKO  4KO0  4LSL  4LSN  4MFB  4O44  4O4G  4OJR  4PQU  4PUO  4PWD  4Q0B  4QAG  4R5P  4RW4  4RW6  4RW7  4RW8  4RW9  4U8W  4WE1  4YE3  4YHQ  4ZIP  4ZLS  5AGZ  5AH6  5AH7  5AH8  5AH9  5AHA  5AHB  5AHC  5BRY  5BS4  5C24  5C25  5C42  5CYM  5CYQ  5D3G  5FDL  5HBM  5HLF  5HP1  5HRO  5I3U  5I42  5J1E  5JFP  5JFU  5JG1  5TEP  5TER 

REV_HV1B1Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1B1Protein Tat (Transactivating regulatory protein)
VIF_HV1B1Virion infectivity factor (Vif) (SOR protein)
VPR_HV1B1Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV1B1Protein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

Select_all Deselect_all  
ENV_HV1BREnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1BRGag polyprotein (Pr55Gag)
NEF_HV1BRProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1BRGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1BRProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1BRProtein Tat (Transactivating regulatory protein)
VIF_HV1BRVirion infectivity factor (Vif) (SOR protein)
VPR_HV1BRProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1BRProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

Select_all Deselect_all  
ENV_HV1H2Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1H2Gag polyprotein (Pr55Gag)
NEF_HV1H2Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1H2Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1H2Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1H2Protein Tat (Transactivating regulatory protein)
VIF_HV1H2Virion infectivity factor (Vif) (SOR protein)
VPR_HV1H2Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV1H2Protein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain

Select_all Deselect_all  
ENV_HV193Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV193Gag polyprotein (Pr55Gag)
NEF_HV193Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV193Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV193Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV193Protein Tat (Transactivating regulatory protein)
VIF_HV193Virion infectivity factor (Vif) (SOR protein)
VPR_HV193Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV193Protein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain

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ENV_HV1VIEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1VIGag polyprotein (Pr55Gag)
NEF_HV1VIProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1VIGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1VIProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1VIProtein Tat (Transactivating regulatory protein)
VIF_HV1VIVirion infectivity factor (Vif) (SOR protein)
VPR_HV1VIProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1VIProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain

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ENV_HV1ANEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1ANGag polyprotein (Pr55Gag)
NEF_HV1ANProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1ANGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1ANProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1ANProtein Tat (Transactivating regulatory protein)
VIF_HV1ANVirion infectivity factor (Vif) (SOR protein)
VPR_HV1ANProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1ANProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1) reference strain

Select_all Deselect_all  
ENV_HV1MVEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1MVGag polyprotein (Pr55Gag)
NEF_HV1MVProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1MVGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1MVProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1MVProtein Tat (Transactivating regulatory protein)
VIF_HV1MVVirion infectivity factor (Vif) (SOR protein)
VPR_HV1MVProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1MVProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)

Select_all Deselect_all  
ENV_HV1A2Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1A2Gag polyprotein (Pr55Gag)
NEF_HV1A2Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1A2Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1A2Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1A2Protein Tat (Transactivating regulatory protein)
VIF_HV1A2Virion infectivity factor (Vif) (SOR protein)
VPR_HV1A2Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV1A2Protein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)

Select_all Deselect_all  
ENV_HV1JREnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1JRGag polyprotein (Pr55Gag)
NEF_HV1JRProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1JRGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1JRProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1JRProtein Tat (Transactivating regulatory protein)
VIF_HV1JRVirion infectivity factor (Vif) (SOR protein)
VPR_HV1JRProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1JRProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1)

Select_all Deselect_all  
ENV_HV1MNEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1MNGag polyprotein (Pr55Gag)
NEF_HV1MNProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1MNGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1MNProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1MNProtein Tat (Transactivating regulatory protein)
VIF_HV1MNVirion infectivity factor (Vif) (SOR protein)
VPR_HV1MNProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1MNProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)

Select_all Deselect_all  
ENV_HV1RHEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1RHGag polyprotein (Pr55Gag)
NEF_HV1RHProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1RHGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1RHProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1RHProtein Tat (Transactivating regulatory protein)
VIF_HV1RHVirion infectivity factor (Vif) (SOR protein)
VPR_HV1RHProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1RHProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

Select_all Deselect_all  
ENV_HV1Y2Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1Y2Gag polyprotein (Pr55Gag)
NEF_HV1Y2Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1Y2Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1Y2Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1Y2Protein Tat (Transactivating regulatory protein)
VIF_HV1Y2Virion infectivity factor (Vif) (SOR protein)
VPR_HV1Y2Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV1Y2Protein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)

Select_all Deselect_all  
ENV_HV1B9Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1B9Gag polyprotein (Pr55Gag)
NEF_HV1B9Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1B9Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1B9Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1B9Protein Tat (Transactivating regulatory protein)
VIF_HV1B9Virion infectivity factor (Vif) (SOR protein)
VPR_HV1B9Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV1B9Protein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)

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ENV_HV192Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV192Gag polyprotein (Pr55Gag)
NEF_HV192Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV192Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV192Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV192Protein Tat (Transactivating regulatory protein)
VIF_HV192Virion infectivity factor (Vif) (SOR protein)
VPR_HV192Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV192Protein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1)

Select_all Deselect_all  
ENV_HV1ETEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1ETGag polyprotein (Pr55Gag)
NEF_HV1ETProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1ETGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1ETProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1ETProtein Tat (Transactivating regulatory protein)
VIF_HV1ETVirion infectivity factor (Vif) (SOR protein)
VPR_HV1ETProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1ETProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1)

Select_all Deselect_all  
ENV_HV1ELEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1ELGag polyprotein (Pr55Gag)
NEF_HV1ELProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1ELGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1ELProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1ELProtein Tat (Transactivating regulatory protein)
VIF_HV1ELVirion infectivity factor (Vif) (SOR protein)
VPR_HV1ELProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1ELProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)

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ENV_HV190Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV190Gag polyprotein (Pr55Gag)
NEF_HV190Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV190Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV190Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV190Protein Tat (Transactivating regulatory protein)
VIF_HV190Virion infectivity factor (Vif) (SOR protein)
VPR_HV190Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV190Protein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

Select_all Deselect_all  
ENV_HV1YBEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1YBGag polyprotein (Pr55Gag)
NEF_HV1YBProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1YBGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1YBProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1YBProtein Tat (Transactivating regulatory protein)
VIF_HV1YBVirion infectivity factor (Vif) (SOR protein)
VPR_HV1YBProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1YBProtein Vpu (U ORF protein) (Viral protein U)

9 entries

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1)

Select_all Deselect_all  
ENV_HV1YFEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1YFGag polyprotein (Pr55Gag)
NEF_HV1YFProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1YFGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1YFProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1YFProtein Tat (Transactivating regulatory protein)
VIF_HV1YFVirion infectivity factor (Vif) (SOR protein)
VPR_HV1YFProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1YFProtein Vpu (U ORF protein) (Viral protein U)

8 entries

Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)

Select_all Deselect_all  
ENV_HV1OYEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1OYGag polyprotein (Pr55Gag)
NEF_HV1OYProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1OYGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1OYProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1OYProtein Tat (Transactivating regulatory protein)
VIF_HV1OYVirion infectivity factor (Vif) (SOR protein)
VPR_HV1OYProtein Vpr (R ORF protein) (Viral protein R)

8 entries

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)

Select_all Deselect_all  
ENV_HV1NDEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1NDGag polyprotein (Pr55Gag)
NEF_HV1NDProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1NDGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1NDProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1NDProtein Tat (Transactivating regulatory protein)
VIF_HV1NDVirion infectivity factor (Vif) (SOR protein)
VPU_HV1NDProtein Vpu (U ORF protein) (Viral protein U)

8 entries

Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)

Select_all Deselect_all  
ENV_HV1Z2Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1Z2Gag polyprotein (Pr55Gag)
POL_HV1Z2Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1Z2Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1Z2Protein Tat (Transactivating regulatory protein)
VIF_HV1Z2Virion infectivity factor (Vif) (SOR protein)
VPR_HV1Z2Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV1Z2Protein Vpu (U ORF protein) (Viral protein U)

8 entries

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)

Select_all Deselect_all  
ENV_HV1MPEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1MPGag polyprotein (Pr55Gag)
NEF_HV1MPProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1MPGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1MPProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1MPProtein Tat (Transactivating regulatory protein)
VIF_HV1MPVirion infectivity factor (Vif) (SOR protein)
VPR_HV1MPProtein Vpr (R ORF protein) (Viral protein R)

8 entries

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)

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ENV_HV1M2Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1M2Gag polyprotein (Pr55Gag)
NEF_HV1M2Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1M2Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1M2Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1M2Protein Tat (Transactivating regulatory protein)
VIF_HV1M2Virion infectivity factor (Vif) (SOR protein)
VPR_HV1M2Protein Vpr (R ORF protein) (Viral protein R)

8 entries

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)

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ENV_HV19NEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV19NGag polyprotein (Pr55Gag)
NEF_HV19NProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV19NGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV19NProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV19NProtein Tat (Transactivating regulatory protein)
VIF_HV19NVirion infectivity factor (Vif) (SOR protein)
VPR_HV19NProtein Vpr (R ORF protein) (Viral protein R)

8 entries

Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)

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ENV_HV1V9Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1V9Gag polyprotein (Pr55Gag)
NEF_HV1V9Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1V9Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1V9Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1V9Protein Tat (Transactivating regulatory protein)
VIF_HV1V9Virion infectivity factor (Vif) (SOR protein)
VPR_HV1V9Protein Vpr (R ORF protein) (Viral protein R)

8 entries

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)

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ENV_HV1S9Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1S9Gag polyprotein (Pr55Gag)
NEF_HV1S9Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1S9Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1S9Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1S9Protein Tat (Transactivating regulatory protein)
VIF_HV1S9Virion infectivity factor (Vif) (SOR protein)
VPR_HV1S9Protein Vpr (R ORF protein) (Viral protein R)

8 entries

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)

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ENV_HV1S2Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1S2Gag polyprotein (Pr55Gag)
NEF_HV1S2Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1S2Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1S2Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1S2Protein Tat (Transactivating regulatory protein)
VIF_HV1S2Virion infectivity factor (Vif) (SOR protein)
VPR_HV1S2Protein Vpr (R ORF protein) (Viral protein R)

8 entries

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)

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ENV_HV196Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV196Gag polyprotein (Pr55Gag)
NEF_HV196Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV196Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV196Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV196Protein Tat (Transactivating regulatory protein)
VIF_HV196Virion infectivity factor (Vif) (SOR protein)
VPR_HV196Protein Vpr (R ORF protein) (Viral protein R)

8 entries

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)

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ENV_HV197Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV197Gag polyprotein (Pr55Gag)
NEF_HV197Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV197Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV197Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV197Protein Tat (Transactivating regulatory protein)
VIF_HV197Virion infectivity factor (Vif) (SOR protein)
VPR_HV197Protein Vpr (R ORF protein) (Viral protein R)

7 entries

Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)

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ENV_HV1LWEnvelope glycoprotein gp160 (Env polyprotein)
GAG_HV1LWGag polyprotein (Pr55Gag)
NEF_HV1LWProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1LWGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1LWProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
VIF_HV1LWTruncated virion infectivity factor (Vif) (SOR protein)
VPU_HV1LWProtein Vpu (U ORF protein) (Viral protein U)

7 entries

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)

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GAG_HV1SEGag polyprotein (Pr55Gag)
NEF_HV1SEProtein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1SEGag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1SEProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1SEProtein Tat (Transactivating regulatory protein)
VIF_HV1SEVirion infectivity factor (Vif) (SOR protein)
VPR_HV1SEProtein Vpr (R ORF protein) (Viral protein R)

6 entries

Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)

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GAG_HV1U4Gag polyprotein (Pr55Gag)
NEF_HV1U4Protein Nef (3'ORF) (Negative factor) (F-protein)
POL_HV1U4Gag-Pol polyprotein (Pr160Gag-Pol)
REV_HV1U4Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1U4Protein Tat (Transactivating regulatory protein)
VIF_HV1U4Virion infectivity factor (Vif) (SOR protein)

6 entries

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

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ENV_HV1H3Envelope glycoprotein gp160 (Env polyprotein)
NEF_HV1H3Protein Nef (3'ORF) (Negative factor) (F-protein)
REV_HV1H3Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1H3Protein Tat (Transactivating regulatory protein)
VPR_HV1H3Protein Vpr (R ORF protein) (Viral protein R)
VPU_HV1H3Protein Vpu (U ORF protein) (Viral protein U)

6 entries

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)

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ENV_HV1SCEnvelope glycoprotein gp160 (Env polyprotein)
NEF_HV1SCProtein Nef (3'ORF) (Negative factor) (F-protein)
REV_HV1SCProtein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1SCProtein Tat (Transactivating regulatory protein)
VPR_HV1SCProtein Vpr (R ORF protein) (Viral protein R)
VPU_HV1SCProtein Vpu (U ORF protein) (Viral protein U)

5 entries

Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)

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ENV_HV1C4Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1C4Gag polyprotein (Pr55Gag)
REV_HV1C4Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1C4Protein Tat (Transactivating regulatory protein)
VPU_HV1C4Protein Vpu (U ORF protein) (Viral protein U)

5 entries

Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)

5 entries

Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)

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NEF_HV112Protein Nef (3'ORF) (Negative factor) (F-protein)
REV_HV112Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV112Protein Tat (Transactivating regulatory protein)
VIF_HV112Virion infectivity factor (Vif) (SOR protein)
VPR_HV112Protein Vpr (R ORF protein) (Viral protein R)

5 entries

Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)

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ENV_HV1S1Envelope glycoprotein gp160 (Env polyprotein)
NEF_HV1S1Protein Nef (3'ORF) (Negative factor) (F-protein)
REV_HV1S1Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1S1Protein Tat (Transactivating regulatory protein)
VPU_HV1S1Protein Vpu (U ORF protein) (Viral protein U)

5 entries

Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)

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ENV_HV1S3Envelope glycoprotein gp160 (Env polyprotein)
NEF_HV1S3Protein Nef (3'ORF) (Negative factor) (F-protein)
REV_HV1S3Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1S3Protein Tat (Transactivating regulatory protein)
VPR_HV1S3Protein Vpr (R ORF protein) (Viral protein R)

5 entries

Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)

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ENV_HV1Z6Envelope glycoprotein gp160 (Env polyprotein)
NEF_HV1Z6Protein Nef (3'ORF) (Negative factor) (F-protein)
REV_HV1Z6Protein Rev (ART/TRS) (Anti-repression transactivator) (Regulator of expression ...
TAT_HV1Z6Protein Tat (Transactivating regulatory protein)
VIF_HV1Z6Virion infectivity factor (Vif) (SOR protein)

4 entries

Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1)

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GAG_HV1B5Gag polyprotein (Pr55Gag)
POL_HV1B5Gag-Pol polyprotein (Pr160Gag-Pol)
VIF_HV1B5Virion infectivity factor (Vif) (SOR protein)
VPR_HV1B5Protein Vpr (R ORF protein) (Viral protein R)

3 entries

Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)

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ENV_HV1B8Envelope glycoprotein gp160 (Env polyprotein)
NEF_HV1B8Protein Nef (3'ORF) (Negative factor) (F-protein)
VPU_HV1B8Protein Vpu (U ORF protein) (Viral protein U)

3 entries

Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)

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ENV_HV1BNEnvelope glycoprotein gp160 (Env polyprotein)
NEF_HV1BNProtein Nef (3'ORF) (Negative factor) (F-protein)
VPU_HV1BNProtein Vpu (U ORF protein) (Viral protein U)

3 entries

Human immunodeficiency virus type 1 group M subtype B (isolate JH32) (HIV-1)

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ENV_HV1J3Envelope glycoprotein gp160 (Env polyprotein)
GAG_HV1J3Gag polyprotein (Pr55Gag)
VPU_HV1J3Protein Vpu (U ORF protein) (Viral protein U)

2 entries

Human immunodeficiency virus type 1 group M subtype A (isolate Z321) (HIV-1)

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ENV_HV1ZHEnvelope glycoprotein gp160 (Env polyprotein)
NEF_HV1ZHProtein Nef (3'ORF) (Negative factor) (F-protein)

2 entries

Human immunodeficiency virus type 1 group M subtype U (isolate Z3) (HIV-1)

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ENV_HV1Z3Truncated surface protein (SU) (Glycoprotein 120) (gp120)
VPU_HV1Z3Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate KB-1/ETR) (HIV-1)


ENV_HV1KBEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MFA) (HIV-1)


ENV_HV1MFEnvelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate N1T-A) (HIV-1)


VIF_HV1NAVirion infectivity factor (Vif) (SOR protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate WMJ1) (HIV-1)


ENV_HV1W1Envelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate WMJ22) (HIV-1)


ENV_HV1W2Envelope glycoprotein gp160 (Env polyprotein)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z84) (HIV-1)


ENV_HV1Z8Envelope glycoprotein gp160 (Env polyprotein)