Virgaviridae

VIRION

Non-enveloped, rigid helical rods with a helical symmetry, about 20-25 nm in diameter with a central “canal”. There may be one, two or three segments depending on the considered genus.

GENOME

Monopartite or segmented (depending on the considered genus), linear, ssRNA(+) genome. Genomic RNA displays a tRNA-like structure in 3’, but no poly-A tail, except for some hordeiviruses which have an internal poly-A tract between the coding sequence and the tRNA-like structure.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The RNA-1 5’-proximal ORFs are directly translated to produce the viral constituents of the replicase complex. RdRp is translated through suppression of termination at the end of ORF1 in most genera. The downstream genes encoding the movement protein, viral suppressor of RNA silencing and capsid proteins are usually translated from subgenomic RNAs.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated to produce the two proteins necessary for RNA synthesis (replication and transcription).
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. The RdRp recognizes internal subgenomic promoters on the negative-sense RNA to transcribe the 3’co-terminal subgenomic RNAs that will generate the capsid protein, movement protein and viral suppressor of RNA silencing.
  7. Virus assembly in the cytoplasm. Each segment (if multipartite) is encapsidated.
  8. Viral movement protein probably mediate virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Soilborne wheat mosaic virus (furovirus) 19K protein suppresses RNA silencing .

P15 of peanut clump virus (pecluvirus) suppresses RNA silencing .

Barley stripe mosaic virus (hordeivirus)gamma-b protein suppresses RNA silencing .

Tobacco mosaic tobamovirus (tobamovirus)126-kDa small replicase subunit suppresses RNA silencing .

Tobacco rattle virus (tobravirus)16K protein suppresses RNA silencing .

Matching UniProtKB/Swiss-Prot entries

126 entries grouped by strain (browse by keywords)

All proteins are shown (view only 86 complete proteome entries)

7 entries

Barley stripe mosaic virus (BSMV) reference strain

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ALPHA_BSMVAlpha-A protein
CAPSD_BSMVCapsid protein (Beta-A protein) (Coat protein)
RDRP_BSMVRNA-directed RNA polymerase (EC 2.7.7.48) (Gamma-A protein)
TGB1_BSMVMovement protein TGB1 (58 kDa protein) (Beta-B protein) (Triple gene block 1 ...
TGB2_BSMVMovement protein TGB2 (14 kDa protein) (Beta-D protein) (Triple gene block 2 ...
TGB3_BSMVMovement protein TGB3 (17 kDa protein) (Beta-C protein) (Triple gene block 3 ...
VSR_BSMVSuppressor of RNA silencing (Gamma-B protein)

7 entries

Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain

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CAPSD_PCV87Capsid protein (Coat protein) (P23)
P39_PCV87Protein P39
RDRP_PCV87Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...
TGB1_PCV87Movement protein TGB1 (P51) (Triple gene block 1 protein) (TGBp1)
TGB2_PCV87Movement protein TGB2 (P14) (Triple gene block 2 protein) (TGBp2)
TGB3_PCV87Movement protein TGB3 (P17) (Triple gene block 3 protein) (TGBp3)
VSR_PCV87Suppressor of RNA silencing (15kD cysteine rich protein) (P15)

7 entries

Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV) reference strain

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CAPSD_PMTVSCapsid protein (Coat protein)
CPRT_PMTVS91 kDa readthrough protein (CP-RT)
RDRP_PMTVSReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...
TGB1_PMTVSMovement protein TGB1 (P51) (Triple gene block 1 protein) (TGBp1)
TGB2_PMTVSMovement protein TGB2 (P14) (Triple gene block 2 protein) (TGBp2)
TGB3_PMTVSMovement protein TGB3 (P21) (Triple gene block 3 protein) (TGBp3)
VSR_PMTVSSuppressor of RNA silencing (8kD cysteine rich protein) (P8)

6 entries

Tobacco rattle virus (isolate PpK20) (TRV) reference strain

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CAPSD_TRVPPCapsid protein (Coat protein) (P23)
MVP_TRVPPMovement protein (29 kDa protein) (Cell-to-cell transport protein) (P1a)
P32_TRVPP32 kDa protein
P40_TRVPP40 kDa protein
RDRP_TRVPPReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...
VSR_TRVPPSuppressor of RNA silencing (16kD cysteine rich protein) (P16)

5 entries

Soil-borne wheat mosaic virus (strain United States/Nebraska/1981) (SBWMV) reference strain

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CAPSD_SBWMNCapsid protein (Coat protein) (P19)
CPRT_SBWMN84 kDa readthrough protein (CP-RT)
MVP_SBWMNMovement protein (37 kDa protein) (Cell-to-cell transport protein)
RDRP_SBWMNReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...
VSR_SBWMNSuppressor of RNA silencing (19kD cysteine rich protein) (P19)

3 entries

Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1)) reference strain

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CAPSD_TMVCapsid protein (Coat protein)
MVP_TMVMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TMVReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Cucumber green mottle mosaic virus (strain watermelon SH) (CGMMV)

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CAPSD_CGMVSCapsid protein (Coat protein)
MVP_CGMVSMovement protein (28.8 kDa protein) (Cell-to-cell transport protein)
RDRP_CGMVSReplicase large subunit (EC 2.7.7.48) (186 kDa protein)

3 entries

Odontoglossum ringspot virus (isolate Korean Cy) (ORSV-Cy)

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CAPSD_ORSVCCapsid protein (Coat protein)
MVP_ORSVCMovement protein (33.4 kDa protein) (Cell-to-cell transport protein)
RDRP_ORSVCReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Odontoglossum ringspot virus (isolate Singapore 1) (ORSV)

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CAPSD_ORSVSCapsid protein (Coat protein)
MVP_ORSVSMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_ORSVSReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Pea early browning virus

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2B_PEBVProtein 2b (29.6 kDa protein)
COAT_PEBVCoat protein (Capsid protein)
V23K_PEBV23 kDa protein

3 entries

Pepper mild mottle virus (strain Japan) (PMMV-J)

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CAPSD_PMMVJCapsid protein (Coat protein)
MVP_PMMVJMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_PMMVJReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Pepper mild mottle virus (strain Spain) (PMMV-S)

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CAPSD_PMMVSCapsid protein (Coat protein)
MVP_PMMVSMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_PMMVSReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Sunn-hemp mosaic virus (SHMV) (TMV strain cowpea)

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CAPSD_SHMVCapsid protein (Coat protein)
MVP_SHMVMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_SHMVReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tobacco mild green mosaic virus (TMGMV) (TMV strain U2)

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CAPSD_TMGMVCapsid protein (Coat protein)
MVP_TMGMVMovement protein (28.5 kDa protein) (Cell-to-cell transport protein)
RDRP_TMGMVReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tobacco mosaic virus (strain B935A) (TMV)

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CAPSD_TMVBCapsid protein (Coat protein)
MVP_TMVBMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TMVBReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tobacco mosaic virus (strain Korean NC 82) (TMV)

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CAPSD_TMVKRCapsid protein (Coat protein)
MVP_TMVKRMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TMVKRReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tobacco mosaic virus (strain OM) (TMV)

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CAPSD_TMVOMCapsid protein (Coat protein)
MVP_TMVOMMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TMVOMReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tobacco mosaic virus (strain Rakkyo) (TMV-R)

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CAPSD_TMVRACapsid protein (Coat protein)
MVP_TMVRAMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TMVRAReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tobacco rattle virus (strain PLB)

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COAT_TRVPLCoat protein (Capsid protein)
V13K_TRVPL16 kDa protein
V16K_TRVPL16 kDa protein

3 entries

Tobacco rattle virus (strain PSG)

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COAT_TRVPSCoat protein (Capsid protein)
V16K_TRVPS16 kDa protein
V29K_TRVPS29 kDa protein

3 entries

Tobacco rattle virus (strain SYM)

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194K_TRVSYReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...
V16K_TRVSY16 kDa protein
V29K_TRVSY29 kDa protein

3 entries

Tobacco rattle virus (strain TCM)

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2B_TRVTCProtein 2b (29.1 kDa protein)
COAT_TRVTCCoat protein (Capsid protein)
V16K_TRVTC16 kDa protein

3 entries

Tobamovirus Ob

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CAPSD_TMOBCapsid protein (Coat protein)
MVP_TMOBMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TMOBReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tomato mosaic virus (strain Kazakh K1) (ToMV) (TMV strain K1)

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CAPSD_TOMK1Capsid protein (Coat protein)
MVP_TOMK1Movement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TOMK1Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tomato mosaic virus (strain Kazakh K2) (ToMV) (TMV strain K2)

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CAPSD_TOMK2Capsid protein (Coat protein)
MVP_TOMK2Movement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TOMK2Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tomato mosaic virus (strain L) (ToMV) (TMV strain tomato)

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CAPSD_TOMLCapsid protein (Coat protein)
MVP_TOMLMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TOMLReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Tomato mosaic virus (strain S-1) (ToMV)

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CAPSD_TOMS1Capsid protein (Coat protein)
MVP_TOMS1Movement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TOMS1Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Turnip vein-clearing virus (TVCV)

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CAPSD_TVCVCapsid protein (Coat protein)
MVP_TVCVMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_TVCVReplicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) ...

3 entries

Youcai mosaic virus (YoMV) (Oilseed rape mosaic virus)

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CAPSD_YOMVCapsid protein (Coat protein)
MVP_YOMVMovement protein (30 kDa protein) (Cell-to-cell transport protein)
RDRP_YOMVReplicase large subunit (EC 2.7.7.48) (182 kDa protein)

2 entries

Cucumber green mottle mosaic virus (strain watermelon W) (CGMMV)

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CAPSD_CGMVWCapsid protein (Coat protein)
MVP_CGMVWMovement protein (28.8 kDa protein) (Cell-to-cell transport protein)

2 entries

Odontoglossum ringspot virus (isolate Japan) (ORSV)

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CAPSD_ORSVJCapsid protein (Coat protein)
MVP_ORSVJMovement protein (33.4 kDa protein) (Cell-to-cell transport protein)

2 entries

Ribgrass mosaic virus (RMV)

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CAPSD_RMVCapsid protein (Coat protein)
MVP_RMVMovement protein (30 kDa protein) (Cell-to-cell transport protein)

1 entry

Paprika mild mottle virus (PaMMV)


CAPSD_PMMVCapsid protein (Coat protein)

1 entry

Pepper mild mottle virus (strain Italian) (PMMV-I)


CAPSD_PMMVICapsid protein (Coat protein)

1 entry

Pepper mild mottle virus (strain P0) (PMMV)


CAPSD_PMMV0Capsid protein (Coat protein)

1 entry

Pepper mild mottle virus (strain P1) (PMMV)


CAPSD_PMMV1Capsid protein (Coat protein)

1 entry

Pepper mild mottle virus (strain P2) (PMMV)


CAPSD_PMMV2Capsid protein (Coat protein)

1 entry

Ribgrass mosaic virus (strain CAB) (RMV)


CAPSD_RMVCACapsid protein (Coat protein)

1 entry

Ribgrass mosaic virus (strain Hr) (RMV) (TMV strain Holmes ribgrass)


CAPSD_RMVHRCapsid protein (Coat protein)

1 entry

Tobacco mosaic virus (strain 06) (TMV-06)


CAPSD_TMV06Capsid protein (Coat protein)

1 entry

Tobacco mosaic virus (strain Dahlemense) (TMV)


CAPSD_TMVDACapsid protein (Coat protein)

1 entry

Tobacco mosaic virus (strain ER) (TMV)


CAPSD_TMVERCapsid protein (Coat protein)

1 entry

Tobacco mosaic virus (strain Kokubu) (TMV)


CAPSD_TMVKOCapsid protein (Coat protein)

1 entry

Tobacco mosaic virus (strain O) (TMV)


CAPSD_TMVOCapsid protein (Coat protein)

1 entry

Tobacco rattle virus (strain CAM)


COAT_TRVCACoat protein (Capsid protein)

1 entry

Tomato mosaic virus (strain Korean) (ToMV)


CAPSD_TOMKOCapsid protein (Coat protein)

1 entry

Tomato mosaic virus (strain LII) (ToMV)


MVP_TOML2Movement protein (30 kDa protein) (Cell-to-cell transport protein)

1 entry

Tomato mosaic virus (strain LIIa) (ToMV)


MVP_TOMLAMovement protein (30 kDa protein) (Cell-to-cell transport protein)