Bafinivirus

VIRION

Enveloped, spherical, about 120 to 140nm in diameter. The tubular nucleocapsid is bend into an open torus hence the name “torovirus”.

GENOME

Monopartite, linear ssRNA(+) genome of 28kb in size. Capped, and polyadenylated.

GENE EXPRESSION

Genomic RNA encodes for ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting proteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5’-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by E2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions.

Matching UniProtKB/Swiss-Prot entries

5 entries grouped by strain (browse by keywords)

5 entries

White bream virus (isolate Blicca bjoerkna L./Germany/DF24/00) (WBV) reference strain

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NCAP_WBV24Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
R1AB_WBV24Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_WBV24Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_WBV24Spike glycoprotein (S glycoprotein)
VME1_WBV24Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...