Respirovirus

VIRION

Enveloped, spherical. Diameter from about 150 nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The C’/C/Y1/Y2 proteins are expressed by leaky scanning, and V/W proteins by mRNA editing.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The C protein plays a role in inhibition of STAT1 antiviral signaling

Matching UniProtKB/Swiss-Prot entries

83 entries grouped by strain (browse by keywords)

All proteins are shown (view only 41 complete proteome entries)

9 entries

Sendai virus (strain Ohita) (SeV) reference strain

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C_SENDOProtein C'
FUS_SENDOFusion glycoprotein F0 (Protein F)
HN_SENDOHemagglutinin-neuraminidase (HN protein) (Protein HANA) (EC 3.2.1.18)
L_SENDORNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_SENDOMatrix protein (M protein)
NCAP_SENDONucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_SENDOPhosphoprotein (Protein P)
V_SENDOProtein V
W_SENDOProtein W

9 entries

Sendai virus (strain Fushimi) (SeV)

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C_SENDFProtein C'
FUS_SENDFFusion glycoprotein F0 (Protein F)
HN_SENDFHemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
L_SENDFRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_SENDFMatrix protein (M protein)
NCAP_SENDFNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_SENDFPhosphoprotein (Protein P)
V_SENDFProtein V
W_SENDFProtein W

9 entries

Sendai virus (strain Hamamatsu) (SeV)

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C_SENDAProtein C'
FUS_SENDAFusion glycoprotein F0 (Protein F)
HN_SENDAHemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
L_SENDARNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_SENDAMatrix protein (M protein)
NCAP_SENDANucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_SENDAPhosphoprotein (Protein P)
V_SENDAProtein V
W_SENDAProtein W

9 entries

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

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C_SENDZProtein C'
FUS_SENDZFusion glycoprotein F0 (Protein F)
HN_SENDZHemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
L_SENDZRNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_SENDZMatrix protein (M protein)
NCAP_SENDZNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_SENDZPhosphoprotein (Protein P)
V_SENDZProtein V
W_SENDZProtein W

7 entries

Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

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C_PI3H4Protein C (VP18 protein)
FUS_PI3H4Fusion glycoprotein F0
HN_PI3H4Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_PI3H4RNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_PI3H4Matrix protein
NCAP_PI3H4Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI3H4Phosphoprotein (Protein P)

7 entries

Sendai virus (strain Harris) (SeV)

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C_SENDHProtein C'
FUS_SENDHFusion glycoprotein F0 (Protein F)
HN_SENDHHemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
MATRX_SENDHMatrix protein (M protein)
PHOSP_SENDHPhosphoprotein (Protein P)
V_SENDHProtein V
W_SENDHProtein W

6 entries

Bovine parainfluenza 3 virus (BPIV-3)

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C_PI3BProtein C
FUS_PI3BFusion glycoprotein F0
HN_PI3BHemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_PI3BMatrix protein
NCAP_PI3BNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI3BPhosphoprotein (Protein P)

5 entries

Human parainfluenza 1 virus (strain C39) (HPIV-1)

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C_PI1HCProtein C
FUS_PI1HCFusion glycoprotein F0
MATRX_PI1HCMatrix protein
NCAP_PI1HCNucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_PI1HCPhosphoprotein (Protein P)

3 entries

Sendai virus (strain Enders) (SeV)

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L_SENDERNA-directed RNA polymerase L (Protein L) (Large structural protein) ...
MATRX_SENDEMatrix protein (M protein)
NCAP_SENDENucleoprotein (Nucleocapsid protein) (NP) (Protein N)

2 entries

Human parainfluenza 1 virus (strain C35) (HPIV-1)

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C_PI1HBProtein C
PHOSP_PI1HBPhosphoprotein (Protein P)

2 entries

Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

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C_PI1HEProtein C
PHOSP_PI1HEPhosphoprotein (Protein P)

2 entries

Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

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C_PI1HDProtein C
PHOSP_PI1HDPhosphoprotein (Protein P)

2 entries

Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1)

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HN_PI1HWHemagglutinin-neuraminidase (EC 3.2.1.18)
NCAP_PI1HWNucleoprotein (Nucleocapsid protein) (NP) (Protein N)

2 entries

Human parainfluenza 1 virus (strains A1426 / 86-315 / 62m-753) (HPIV-1)

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MATRX_PI1HAMatrix protein
NCAP_PI1HANucleoprotein (Nucleocapsid protein) (NP) (Protein N)

2 entries

Sendai virus (strain 6/94) (SeV)

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C_SEND6Protein C'
PHOSP_SEND6Phosphoprotein (Protein P)

1 entry

Human parainfluenza 3 virus (strain Aus/124854/74) (HPIV-3)


HN_PI3HAHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Tex/12677/83) (HPIV-3)


HN_PI3HVHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Tex/545/80) (HPIV-3)


HN_PI3HTHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Tex/9305/82) (HPIV-3)


HN_PI3HUHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Wash/1511/73) (HPIV-3)


HN_PI3HXHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Human parainfluenza 3 virus (strain Wash/641/79) (HPIV-3)


HN_PI3HWHemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Sendai virus (strain Nagoya) (SeV)


C_SENDNProtein C'