Host-virus interactions

ifnsignaling mda_rig pkr host shuttoff antiviral state apoptosis cell cycle mhc cytokines lysis autophagy



Main process Detailled processes
Early cell antiviral response:
MDA5-RIGI pathway
MDA5 inhibition
RIG-I inhibition
MAVS inhibition
TRAFs mediated response inhibition
IRF3 inhibition
IRF7 inhibition
IKKE/TBK1/DDX3 complex inhibition
Early cell antiviral response:
PKR
PKR inhibition
PP1 modulation
Cross-cell antiviral response:
Interferon signaling
STAT1 inhibition
STAT2 inhibition
IRF9 complex inhibition
TYK2 inhibition
JAK1 inhibition
Interferon receptors inhibition
Interferon-induced response:
Antiviral state establishment
ISG15 inhibition
Tetherin inhibition
Late cell immune response:
Adaptive response
Inhibition of proteasome antigen processing
MHC class I molecule presentation inhibition
MHC class II molecule presentation inhibition
Inhibition of TAP function
Inhibition of tapasin function
Host Immunity modulationInhibition of soluble complement factors
Chemokine regulators
Viral interleukin-like protein
Viral IgG Fc receptors
Host transcription modulationNF-kappa-B inhibition
NF-kappa-B activation
AutophagyHost autophagy inhibition
Host autophagy activation
Apoptosis modulation Host apoptosis activation
Host apoptosis inhibition
Viral FLIPs
Viral BCL2s
Host genes expression shutoff by virus Virus-mediated host mRNA decay
Inhibition of host mRNA nuclear export by virus
Inhibition of host pre-mRNA processing by virus
Inhibition of host transcription initiation by virus
Inhibition of host RNA polymerase II by virus
Cleavage of host translation factors by virus
Dephosphorylation of host translation factors
Inhibition of host poly(A)-binding protein by virus